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Liver Cirrhosis, Etiology and Clinical Characteristics Disparities Among Minority Population

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Abstract

Liver cirrhosis (LC) is a common disease with varied primary causes and ethnic disparities. Clinical characteristics and outcomes of Arab Bedouin (AB) and Jewish patients with LC were retrospective collected and compared. We included 1048 patients, 95 (9%) Arab Bedouin and 953 (91%) Jewish patients. The incidence of cirrhosis was much lower among AB. Age at diagnosis was 47 ± 18 years among Bedouins compared to 61 ± 13 years (p < 0.001) among Jews. The most frequent causes of cirrhosis among Bedouin patients were fatty liver 21.1%, cryptogenic 20%, hepatitis B 17.9% and autoimmune hepatitis 15.8%, while hepatitis C (39.2%), fatty liver (17.2%) and alcoholic liver disease (14.4%) were most common among Jewish patients. An all-cause mortality of 48.4% was observed in AB patients compared to 66.4% in Jewish patients (p < 0.001). Significant disparities regarding incidence, clinical characteristics and outcomes of cirrhosis among Arab Bedouin compared with Jewish population were found.

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Abbreviations

AB:

Arab Bedouin

LC:

Liver cirrhosis

HCC:

Hepatocellular Carcinoma

SBP:

Spontanous Bacterial Peritonitis

NAFLD:

Non-Alcoholic Fatty Liver Disease (NAFLD)

PBC:

Primary Biliary Cholangitis

PSC:

Primary Sclerosing Cholangitis

Hb:

Hemoglobin

WBC:

White Blood Cells

PLT:

Platelets

ALT:

Alanine transaminase

AST:

Asparatate transaminase

AP:

Alkaline Phosphatase

GGT:

Gamma-Glutamyl Transferase

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Authors and Affiliations

  1. Recanati School for Community Health Professions, Department of Nursing, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheba, Israel

    Muhammad Abu Tailakh

  2. Soroka University Medical Center, Beersheba, Israel

    Muhammad Abu Tailakh

  3. Medical School for International Health, Ben-Gurion University, Beersheba, Israel

    Liat Poupko

  4. Division of Internal Medicine, Soroka University Medical Center, Beersheba, Israel

    Najwan Kayyal, Ali Alsana & Asia Estis-Deaton

  5. The Institute of Gastroenterology and Hepatology, Soroka University Medical Center, P.O. Box 151, 84101, Beersheba, Israel

    Ohad Etzion, Alexander Fich, David Yardni & Naim Abu-Freha

  6. Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheba, Israel

    Ohad Etzion, Alexander Fich, David Yardni & Naim Abu-Freha

Authors
  1. Muhammad Abu Tailakh
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  2. Liat Poupko
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  4. Ali Alsana
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  9. Naim Abu-Freha
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All authors have contributed significantly to the work and have approved the final version of the manuscript.

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Correspondence to Naim Abu-Freha.

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Tailakh, M.A., Poupko, L., Kayyal, N. et al. Liver Cirrhosis, Etiology and Clinical Characteristics Disparities Among Minority Population. J Immigrant Minority Health 24, 1122–1128 (2022). https://doi.org/10.1007/s10903-021-01263-y

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  • DOI: https://doi.org/10.1007/s10903-021-01263-y

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