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Resveratrol Inhibits Respiratory Syncytial Virus-Induced IL-6 Production, Decreases Viral Replication, and Downregulates TRIF Expression in Airway Epithelial Cells

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Abstract

Respiratory syncytial virus (RSV) is the most common pathogen responsible for lower respiratory diseases in children. So far, there is no effective treatment or preventative vaccine available for RSV infection, although ribavirin and dexamethasone are commonly prescribed. Resveratrol has been shown to inhibit the replication of several other viruses, thus the effect of resveratrol on RSV-induced inflammatory mediators in 9HTEo cell cultures was evaluated, and possible mechanisms of action were explored and compared with dexamethasone and ribavirin. Incubation with resveratrol resulted in decreased IL-6 production and partial inhibition of RSV replication. Resveratrol treatment also inhibited virus-induced TIR-domain-containing adapter-inducing interferon-β (TRIF) and TANK binding kinase 1 (TBK1) protein expression. These data demonstrate the ability of resveratrol to inhibit cytokine production by RSV in airway epithelial cells, indicating that it might be a therapeutic agent with both anti-inflammatory and antiviral potential for the treatment of RSV infection.

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ACKNOWLEDGMENTS

This study was supported by the Program for New Century Excellent Talents in University (06-775), the Key program of Chongqing Medical University, and Specialized Research Fund for the Doctoral Program of Higher Education of China (Grant No. 20105503120003)

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Authors and Affiliations

  1. Department of Respiratory Medicine, Children’s Hospital of Chongqing Medical University, Chongqing, 400014, People’s Republic of China

    Xiao-hong Xie, Na Zang, Yu Deng & En-mei Liu

  2. Ministry of Education, Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing CSTC2009CA5002, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing, 400014, People’s Republic of China

    Xiao-hong Xie, Na Zang, Si-min Li, Li-jia Wang & Yu Deng

  3. Pediatric Department, Department of Pediatrics, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province, 637000, People’s Republic of China

    Yun He

  4. Department of Nephrology and Immunology, Children’s Hospital of Chongqing Medical University, Chongqing, 400014, People’s Republic of China

    Xi-qiang Yang

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  1. Xiao-hong Xie
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Correspondence to En-mei Liu.

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Xie, Xh., Zang, N., Li, Sm. et al. Resveratrol Inhibits Respiratory Syncytial Virus-Induced IL-6 Production, Decreases Viral Replication, and Downregulates TRIF Expression in Airway Epithelial Cells. Inflammation 35, 1392–1401 (2012). https://doi.org/10.1007/s10753-012-9452-7

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  • DOI: https://doi.org/10.1007/s10753-012-9452-7

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