Abstract
Tripartite motif (TRIM) protein superfamily is a group of E3 ubiquitin ligases characterized by the conserved RING domain, the B-box domain, and the coiled-coil domain (RBCC). It is widely involved in various physiological and pathological processes, such as intracellular signal transduction, cell cycle regulation, oncogenesis, and innate immune response. Central nervous system (CNS) diseases are composed of encephalopathy and spinal cord diseases, which have a high disability and mortality rate. Patients are often unable to take care of themselves and their life quality can be seriously declined. Initially, the function research of TRIM proteins mainly focused on cancer. However, in recent years, accumulating attention is paid to the roles they play in CNS diseases. In this review, we integrate the reported roles of TRIM proteins in the pathological process of CNS diseases and related signaling pathways, hoping to provide theoretical bases for further research in treating CNS diseases targeting TRIM proteins.
Graphical Abstract
TRIM proteins participated in CNS diseases. TRIM protein family is characterized by a highly conserved RBCC domain, referring to the RING domain, the B-box domain, and the coiled-coil domain. Recent research has discovered the relations between TRIM proteins and various CNS diseases, especially Alzheimer’s disease, Parkinson’s disease, and ischemic stroke.
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This work was supported by the Natural Science Foundation of Jiangsu Province of China (Program No. BK202013 28) and the Natural Science Foundation of China (Program No. 82073845, 82174051).
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MP contributed to conception of the study, acquisition of data and analysis, and drafting the article. XL contributed to conception of the study and revising article critically. GX and XT contributed to revising article critically. YL contributed to study supervision. WF contributed to review, revision of the manuscript, and study supervision. All authors approved the version to be published and agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
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Pan, M., Li, X., Xu, G. et al. Tripartite Motif Protein Family in Central Nervous System Diseases. Cell Mol Neurobiol 43, 2567–2589 (2023). https://doi.org/10.1007/s10571-023-01337-5
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DOI: https://doi.org/10.1007/s10571-023-01337-5