Skip to main content
Springer Nature Link
Log in

Expression of Neuropeptides, Neurotrophins, and Neurotransmitters in the Skin of Patients with Atopic Dermatitis and Psoriasis

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Expression of neural marker PGP9.5, amphiregulin, semaphorin-3A, calcitonin gene-related peptide and its receptor, nerve growth factor and its receptor, substance P and its receptor, and expression frequency were analyzed in biopsy specimens from patients with atopic dermatitis and psoriasis and healthy volunteers by immunohistochemical method. Nerve fibers penetrated into the epidermis more frequently, and amphiregulin expression was significantly higher in patients with atopic dermatitis and psoriasis comparing to the control. Expression of semaphorin-3A in patients with atopic dermatitis was less frequent than in the control. These findings reflect the involvement of amphiregulin and semaphorin-3A in the improvement of skin innervations and penetration of nerve fibers into the epidermis, and due of which these proteins mediate the development of itch.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (Canada)

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. O. R. Katunina, V. V. Chikin, L. F. Znamenskaya, and L. A. Inoyatova, Vestn. Dermatol. Venerol., No. 5, 91-101 (2013).

  2. K. M. Albers, D. E. Wright, and B. M. Davis, J. Neurosci., 14, No. 3, Pt 2, 1422-1432 (1994).

  3. J. Buddenkotte and M. Steinhoff, Allergy, 65, No. 7, 805-821 (2010).

    Article  CAS  PubMed  Google Scholar 

  4. S. E. Chang, S. S. Han, H. J. Jung, and J. H. Choi, Br. J. Dermatol., 156, No. 6, 1272-1277 (2007).

    Article  PubMed  Google Scholar 

  5. V. D. Dontchev and P. C. Letourneau, J. Neurosci., 22, No. 15, 6659-6669 (2002).

    CAS  PubMed  Google Scholar 

  6. L. Garibyan, C. G. Rheingold, and E. A. Lerner, Dermatol. Ther., 26, No. 2, 84-91 (2013).

    Article  PubMed  Google Scholar 

  7. A. Jarvikallio, I. T. Harvima, and A. Naukkarinen, Arch. Dermatol. Res., 295, No. 1, 2-7 (2003).

    PubMed  Google Scholar 

  8. A. Nilsson and M. Kanje, Neuroreport, 16, No. 3, 213-218 (2005).

    Article  CAS  PubMed  Google Scholar 

  9. E. M. Peters, U. Raap, P. Welker, et al., Horm. Metab. Res., 39, No. 2, 110-124 (2007).

    Article  CAS  PubMed  Google Scholar 

  10. C. Pincelli and M. Steinhoff, J. Invest. Dermatol., 133, No. 6, 1465-1467 (2013).

    Article  CAS  PubMed  Google Scholar 

  11. U. Raap and A. Kapp, Curr. Opin. Allergy Clin. Immunol., 5, No. 5, 419-424 (2005).

    Article  CAS  PubMed  Google Scholar 

  12. D. Roosterman, T. Goerge, S. W. Schneider, et al., Physiol. Rev., 86, No. 4, 1309-1379 (2006).

    Article  CAS  PubMed  Google Scholar 

  13. D. Roggenkamp, S. Falkner, F. Stab, et al., J. Invest. Dermatol., 132, No. 7, 1892-1900 (2012).

    Article  CAS  PubMed  Google Scholar 

  14. A. J. Shepherd, J. E. G. Downing, and J. A. Miyan, Immunology, 116, No. 2, 145-163 (2005).

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  15. M. Steinhoff, S. Stander, S. Seeliger, et al., Arch. Dermatol., 139, No. 11, 1479-1488 (2003).

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. State Research Center for Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation, Moscow, Russia

    A. A. Kubanov, O. R. Katunina & V. V. Chikin

Authors
  1. A. A. Kubanov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. O. R. Katunina
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. V. Chikin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to V. V. Chikin.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 3, pp. 295-299, March, 2015

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kubanov, A.A., Katunina, O.R. & Chikin, V.V. Expression of Neuropeptides, Neurotrophins, and Neurotransmitters in the Skin of Patients with Atopic Dermatitis and Psoriasis. Bull Exp Biol Med 159, 318–322 (2015). https://doi.org/10.1007/s10517-015-2951-4

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-015-2951-4

Key Words

Search

Navigation