Endomyocardial biopsy samples of the interventricular septum from patients with hypertrophic cardiomyopathy isolated during myectomy were examined. We revealed significant variability of cardiomyocyte ploidy (from 2.9c to 13.5c) that directly correlated with myocyte size; the maximum ploidy was found in young patients. Ultrastructural signs of increased contractile and synthetic activity of cells were observed in patients with high DNA content in cardiomyocytes.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 1, pp. 106–111, January, 2015
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Sukhacheva, T.V., Chudinovskikh, Y.A., Eremeeva, M.V. et al. Age-Related Features of Cardiomyocyte Ploidy in Patients with Hypertrophic Obstructive Cardiomyopathy. Bull Exp Biol Med 159, 95–99 (2015). https://doi.org/10.1007/s10517-015-2899-4
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DOI: https://doi.org/10.1007/s10517-015-2899-4