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Research progress of non-coding RNA regulating the role of PANoptosis in diabetes mellitus and its complications

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Abstract

Diabetes is a chronic metabolic disease that is endemic worldwide and is characterized by persistent hyperglycemia accompanied by multiple severe complications, including cardiovascular disease, kidney dysfunction, neuropathy, and retinopathy. The pathogenesis of diabetes mellitus and its complications is multifactorial, involving various molecular and cellular pathways. In recent years, research has indicated that mechanisms of cell death play a significant role in the advancement of diabetes and its complications. PANoptosis is a complex phenomenon caused by three cell death pathways: programmed apoptosis, necroptosis and pyroptosis. The contribution of PANoptosis to diabetes and its complications remains incompletely understood. Non-coding RNA, an important molecule in gene expression regulation, has shown significant regulatory functions in a variety of diseases. This paper reviews the underlying mechanisms of diverse types of non-coding RNAs (including lncRNA, miRNA and circRNA) in regulating PANoptosis and their specific contributions in diabetes, aiming to explore how non-coding RNAs influence PANoptosis and their effects in diabetes.

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Data availability

No datasets were generated or analysed during the current study.

Abbreviations

Type 1 diabetes or T1D:

Early-onset autoimmune diabetes

LADA:

Adult latent autoimmune diabetes

RIPKs:

Receptor interacting serine/threonine protein kinases

HMGB:

High mobility group protein 1

TNF-α:

Tumor necrosis factor α

IL-6:

Interleukin-6

IL-1β:

Interleukin-1β

NF-κB:

Nuclear factor κB

AP-1:

Activating protein-1

ncRNAs:

Non-coding RNAs

miRNAs:

MicroRNAs

lncRNAs:

Long-chain non-coding RNAs

circRNAs:

Circular RNAs

IGF2:

Insulin-like growth factor 2

TLRs:

Toll-like receptors

NEAT1:

Nuclear Enriched Abundant Transcript 1

RBPS:

RNA-binding proteins

DN:

Diabetic nephropathy

TGF-β:

Transforming growth factor-β

DR:

Diabetic retinopathy

VEGF:

Vascular endothelial growth factor

DCM:

Diabetic Cardiomyopathy

TUG1:

Taurine up-regulated gene 1

MEG3:

Maternally Expressed Gene 3

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Acknowledgements

The figures were created with BioRender software (https://www.biorender.com/).

Funding

This review was supported by the National Natural Science Foundation of China [grant number 82160371 to J.Z., 82100869 and 82360162 to P.Y.]; the Natural Science Foundation in Jiangxi Province [grant numbers 20224ACB216009 to J.Z.]; the Jiangxi Province Thousands of Plans [grant number jxsq2023201105 to P.Y.]; Young Elite Scientists Sponsorship Program by JXAST [grant number 2023OT05 to J.Z.], the Hengrui Diabetes Metabolism Research Fund [grant number Z-2017–26-2202–4 to P.Y.], and National College Students Innovation and Entrepreneurship Training Program [grant number 202410403014 to G.H.].

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Authors and Affiliations

  1. Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China

    Guangyu Han, Kaibo Hu, Tianfeng Luo, Jianping Liu, Yuting Wu, Jianqi Liang, Jitao Ling, Rui Xuan & Peng Yu

  2. The Second Clinical Medical College, Nanchang University, Nanchang, 330006, China

    Guangyu Han, Kaibo Hu & Tianfeng Luo

  3. Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China

    Kaibo Hu

  4. Department of Anesthesiology, The Second Affiliated Hospital of Hainan Medical University, Haikou, 571199, China

    Wenting Wang

  5. Ood and Nutritional Sciences, School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, China

    Deju Zhang

  6. Center for Molecular and Translational Medicine, Georgia State University, 157 Decatur Street SE, Atlanta, GA, 30303, USA

    Liu Ouyang

  7. Department of Cardiology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China

    Xiao Liu

  8. Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China

    Yixuan Chen & Jing Zhang

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  1. Guangyu Han
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  2. Kaibo Hu
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  3. Tianfeng Luo
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  15. Peng Yu
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Contributions

All authors have discussed the proposed scope and content of the article before drafting. G.Y.H., K.H.B., and T.F.L. wrote and revised the whole paper. W.T.W., L.O.Y., X.L., and D.J.Z drew and revised the figures. Y.T.W., J.Q.L., J.T.L and Y.X.C. collected literatures. P.Y., J.Z., and R.X. reviewed and edited the manuscript.

Corresponding authors

Correspondence to Rui Xuan, Jing Zhang or Peng Yu.

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Han, G., Hu, K., Luo, T. et al. Research progress of non-coding RNA regulating the role of PANoptosis in diabetes mellitus and its complications. Apoptosis (2025). https://doi.org/10.1007/s10495-024-02066-w

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