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Viral infection and atherosclerosis

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Abstract

Several risk factors have been described for the pathogenesis of atherosclerosis. Infectious diseases are suggested to be a causative factor, and some viruses have been studied for their relation with atherosclerotic diseases. Studies report two hypotheses, direct and indirect effects, for the role of viral infections in atherogenesis. Viruses are able to initiate atherosclerosis by two different pathways. They can exert their direct effects on atherogenesis by infecting vascular cells and then inducing inflammation in the endothelium and smooth muscle cells. Alternatively, they can also apply indirect effects by infecting non-vascular cells and inducing systemic inflammation. In this review, we consider the available data about the effects and correlations of DNA and RNA viruses on atherosclerosis.

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Funding

This project was supported by the Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

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Authors and Affiliations

  1. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Nima Hemmat, Amin Ebadi & Hossein Bannazadeh Baghi

  2. Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, PO Box 5165665931, Tabriz, Iran

    Nima Hemmat, Amin Ebadi, Mohammad Yousef Memar & Hossein Bannazadeh Baghi

  3. Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Reza Badalzadeh

  4. Department of Physiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

    Reza Badalzadeh

  5. Department of Microbiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

    Mohammad Yousef Memar & Hossein Bannazadeh Baghi

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  1. Nima Hemmat
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  2. Amin Ebadi
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  3. Reza Badalzadeh
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  5. Hossein Bannazadeh Baghi
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Correspondence to Hossein Bannazadeh Baghi.

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Hemmat, N., Ebadi, A., Badalzadeh, R. et al. Viral infection and atherosclerosis. Eur J Clin Microbiol Infect Dis 37, 2225–2233 (2018). https://doi.org/10.1007/s10096-018-3370-z

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  • DOI: https://doi.org/10.1007/s10096-018-3370-z

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