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Parthenolide inhibits lipid accumulation via activation of Nrf2/Keap1 signaling during adipocyte differentiation

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Abstract

The effects of parthenolide (PL), a sesquiterpene lactone obtained from feverfew plant, on lipid accumulation and signaling pathway in adipocytes were investigated. PL significantly inhibited lipid accumulation and adipogenic factors during adipogenesis. In particular, PL exerted its inhibitory effects in early adipogenic stage by regulating the early adipogenic factors. In addition, PL regulated the expression of adipokines; leptin, retinol binding protein, and resistin mRNAs were downregulated, whereas adiponectin gene expression was increased. Furthermore, PL significantly reduced intracellular reactive oxygen species (ROS) production during adipogenesis. This PL-mediated regulation of ROS production was associated with the regulation of nuclear factor erythroid 2-related factor (Nrf2)-kelch-like ECH-associated protein 1 (Keap1) pathway. PL effectively increased the abundance of Nrf2 and its target proteins, heme oxygenase-1 (HO-1) and NADPH dehydrogenase 1 (NQO1), by promoting the nuclear translocation of Nrf2, indicating that PL-mediated anti-adipogenic effects are associated with the Nrf2/Keap1 pathway.

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Acknowledgements

This work was supported by the National Research Foundation of Korea, a Grant funded by the Korea government (the Ministry of Education) (NRF‐2015R1D1A1A01059729; 2016), and a research Grant from the Seoul Women’s University (2019).

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Authors and Affiliations

  1. Department of Public Health Sciences, Korea University, Seoul, 07249, Republic of Korea

    Chae Young Kim & Bobin Kang

  2. Department of Food Science and Technology, College of Natural Science, Seoul Women’s University, Seoul, 139-774, Republic of Korea

    Jungil Hong & Hyeon-Son Choi

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  1. Chae Young Kim
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Correspondence to Hyeon-Son Choi.

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Kim, C.Y., Kang, B., Hong, J. et al. Parthenolide inhibits lipid accumulation via activation of Nrf2/Keap1 signaling during adipocyte differentiation. Food Sci Biotechnol 29, 431–440 (2020). https://doi.org/10.1007/s10068-019-00672-y

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