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TRPC1 as a negative regulator for TRPC4 and TRPC5 channels

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Abstract

Transient receptor potential canonical (TRPC) channels are calcium permeable, non-selective cation channels with wide tissue-specific distribution. Among 7 TRPC channels, TRPC 1/4/5 and TRPC3/6/7 are subdivided based on amino acid sequence homology. TRPC4 and TRPC5 channels exhibit cationic current with homotetrameric form, but they also form heterotetrameric channel such as TRPC1/4 or TRPC1/5 once TRPC1 is incorporated. The expression of TRPC1 is ubiquitous whereas the expressions of TRPC4 and TRPC5 are rather focused in nervous system. With the help of conditional knock-out of TPRC1, 4 and/or 5 genes, TRPC channels made of these constituents are reported to be involved in various pathophysiological functions such as seizure, anxiety-like behaviour, fear, Huntington’s disease, Parkinson’s disease and many others. In heterologous expression system, many issues such as activation mechanism, stoichiometry and relative cation permeabilites of homomeric or heteromeric channels have been addressed. In this review, we discussed the role of TRPC1 channel per se in plasma membrane, role of TRPC1 in heterotetrameric conformation (TRPC1/4 or TRPC1/5) and relationship between TRPC1/4/5 channels, calcium influx and voltage-gated calcium channels.

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Acknowledgements

We thank Jungeun Lee for carefully revising the manuscript.

Funding

This study was supported by grants from the National Research Foundation of Korea, which is funded by the Ministry of Science, ICT (Information and Communication Technology) and Future Planning (MSIP) of the Korean government (2018R1A4A1023822).

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Authors and Affiliations

  1. Department of Physiology, College of Medicine, Seoul National University, Seoul, South Korea

    Jinsung Kim, Juyeon Ko, Misun Kwak & Insuk So

  2. Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, WA, USA

    Jongyun Myeong

  3. Department of Physiology, College of Medicine, Chosun University, Kwangju, South Korea

    Chansik Hong

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Kim, J., Ko, J., Myeong, J. et al. TRPC1 as a negative regulator for TRPC4 and TRPC5 channels. Pflugers Arch - Eur J Physiol 471, 1045–1053 (2019). https://doi.org/10.1007/s00424-019-02289-w

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