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Canonical transient receptor potential channel 2 (TRPC2): old name–new games. Importance in regulating of rat thyroid cell physiology

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Abstract

In addition to the TSH-cyclic AMP signalling pathway, calcium signalling is of crucial importance in thyroid cells. Although the importance of calcium signalling has been thoroughly investigated for several decades, the nature of the calcium channels involved in signalling is unknown. In a recent series of investigations using the well-studied rat thyroid FRTL-5 cell line, we showed that these cells exclusively express the transient receptor potential canonical 2 (TRPC2) channel. Our results suggested that the TRPC2 channel is of significant importance in regulating thyroid cell function. These investigations were the first to show that thyroid cells express a member of the TRPC family of ion channels. In this review, we will describe the importance of the TRPC2 channel in regulating TSH receptor expression, thyroglobulin maturation, intracellular calcium and iodide homeostasis and that the channel also regulates thyroid cell proliferation.

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Acknowledgments

There exists an extensive literature both on thyroid function and on TRPC channel physiology. We apologize to all our colleagues whose work we have not been able to cite due to space restriction. The studies emanating from the Törnquist lab were generously supported by the Academy of Finland, the Sigrid Juselius Foundation, the Minerva Foundation, the Centre of Excellence in Cell Stress and Molecular Ageing (Åbo Akademi University), the Magnus Ehrnrooth Foundation, the Borg Foundation, the K. Albin Johansson Foundation and the Oscar Öflund Foundation, which are gratefully acknowledged.

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The authors declares no conflict of interest.

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Authors and Affiliations

  1. Department of Biosciences, Åbo Akademi University, Tykistökatu 6A, 20520, Turku, Finland

    Kid Törnquist & Kati Kemppainen

  2. Minerva Foundation Institute for Medical Research, Biomedicum Helsinki, 00270, Helsinki, Finland

    Kid Törnquist & Tero Viitanen

  3. Department of Biochemistry and Molecular Biology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, 58201, USA

    Pramod Sukumaran

  4. Department of Physiology, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, 20520, Turku, Finland

    Christoffer Löf

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  1. Kid Törnquist
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  2. Pramod Sukumaran
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  3. Kati Kemppainen
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  4. Christoffer Löf
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  5. Tero Viitanen
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Correspondence to Kid Törnquist.

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Törnquist, K., Sukumaran, P., Kemppainen, K. et al. Canonical transient receptor potential channel 2 (TRPC2): old name–new games. Importance in regulating of rat thyroid cell physiology. Pflugers Arch - Eur J Physiol 466, 2025–2034 (2014). https://doi.org/10.1007/s00424-014-1509-z

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  • DOI: https://doi.org/10.1007/s00424-014-1509-z

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