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A requiem to the nuclear matrix: from a controversial concept to 3D organization of the nucleus

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Abstract

The first papers coining the term “nuclear matrix” were published 40 years ago. Here, we review the data obtained during the nuclear matrix studies and discuss the contribution of this controversial concept to our current understanding of nuclear architecture and three-dimensional organization of genome.

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Acknowledgments

This research was supported by the Presidium of the Russian Academy of Sciences (MCB grant to SVR), RFBR grants (12-04-93109, 14-04-00010 to SVR, and 13-04-93105 to OVI) and grants from INCa (ERABL) and ANRS (No 1154) to YSV.

Conflict of interests

The authors declare no conflict of interests.

Author information

Authors and Affiliations

  1. Institute of Gene Biology of the Russian Academy of Sciences, 119334, Moscow, Russia

    S. V. Razin & O. V. Iarovaia

  2. LIA 1066 French-Russian Joint Cancer Research Laboratory 94805 Villejuif, France, 119334, Moscow, Russia

    S. V. Razin, O. V. Iarovaia & Y. S. Vassetzky

  3. Faculty of Biology, M.V. Lomonosov Moscow State University, 119992, Moscow, Russia

    S. V. Razin

  4. UMR8126, Université Paris-Sud, CNRS, Institut de cancérologie Gustave Roussy, 94805, Villejuif, France

    Y. S. Vassetzky

Authors
  1. S. V. Razin
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  2. O. V. Iarovaia
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  3. Y. S. Vassetzky
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Correspondence to Y. S. Vassetzky.

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Razin, S.V., Iarovaia, O.V. & Vassetzky, Y.S. A requiem to the nuclear matrix: from a controversial concept to 3D organization of the nucleus. Chromosoma 123, 217–224 (2014). https://doi.org/10.1007/s00412-014-0459-8

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  • DOI: https://doi.org/10.1007/s00412-014-0459-8

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