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Cyclooxygenase-2 immunoreactivity in the human brain following cerebral ischemia

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Abstract

The prostaglandin synthesizing enzyme cyclooxygenase-2 (COX-2) is up-regulated in the brain of rodents during cerebral ischemia and contributes to ischemic brain injury. This study sought to determine whether COX-2 is also up-regulated in the human brain in the acute stages of cerebral ischemic infarction. Paraffin-embedded sections from patients who died 1–2 days following infarction in the middle cerebral artery territory were processed for COX-2 immunohistochemistry. COX-2 immunoreactivity was observed in infiltrating neutrophils, in vascular cells and in neurons located at the border of the infarct. The data suggest that COX-2 up-regulation is also relevant to cerebral ischemia in humans and raise the possibility that COX-2 reaction products participate in the mechanisms of ischemic injury also in the human brain.

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Authors and Affiliations

  1. Departments of Neurology and Neuroscience, University of Minnesota Medical School, Box 295 UMHC, 516 Delaware Street S.E., Minneapolis, MN 55455, USA e-mail: iadec001@tc.umn.edu Tel.: +1-612-624-1902, Fax: +1-612-625-7950, , , , , , US

    C. Iadecola, Colleen Forster, Shigeru Nogawa & M. Elizabeth Ross

  2. Departments of Neurology and Laboratory Medicine and Pathology (Neuropathology), University of Minnesota, Minneapolis, MN 55455, USA, , , , , , US

    H. Brent Clark

Authors
  1. C. Iadecola
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  2. Colleen Forster
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  3. Shigeru Nogawa
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  4. H. Brent Clark
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  5. M. Elizabeth Ross
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Additional information

Received: 12 January 1999 / Revised, accepted: 8 March 1999

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Iadecola, C., Forster, C., Nogawa, S. et al. Cyclooxygenase-2 immunoreactivity in the human brain following cerebral ischemia. Acta Neuropathol 98, 9–14 (1999). https://doi.org/10.1007/s004010051045

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  • DOI: https://doi.org/10.1007/s004010051045

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