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On the question of apoptosis in the parkinsonian substantia nigra

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Abstract

Apoptosis has been postulated as a mechanism of nerve cell death in Parkinson’s disease. In the present study, the substantia nigra of 22 neuropathologically confirmed Parkinson cases and 8 control brains was studied using the in situ end-labeling (TUNEL) method. About 50% of parkinsonian brains showed a small number of TUNEL-positive glial cells in the substantia nigra, whereas no neurons showed convincing TUNEL positivity or any morphological signs of apoptosis. No correlation was observed between the number of TUNEL-positive glial cells and microglial activation. Our results fail to demonstrate apoptosis as a mechanism of cell death in Parkinson’s disease.

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Authors and Affiliations

  1. Molecular Neuropathology Laboratory and Reference Center for Neurodegenerative Disorders, Institute of Neuropathology, Ludwig-Maximilians University, Thalkirchner Strasse 36, D-80337 Munich, Germany Tel.: 49-89-5160-5192; Fax: 49-89-5160-5197, , , , , , DE

    Siegfried Kösel, Rupert Egensperger, Ulrich von Eitzen, Parviz Mehraein & M. B. Graeber

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  1. Siegfried Kösel
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  2. Rupert Egensperger
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  3. Ulrich von Eitzen
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  4. Parviz Mehraein
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  5. M. B. Graeber
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Received: 11 September 1996 / Revised, accepted: 5 November 1996

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Kösel, S., Egensperger, R., von Eitzen, U. et al. On the question of apoptosis in the parkinsonian substantia nigra. Acta Neuropathol 93, 105–108 (1997). https://doi.org/10.1007/s004010050590

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  • DOI: https://doi.org/10.1007/s004010050590

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