Skip to main content

Advertisement

Springer Nature Link
Log in

Increased myeloperoxidase plasma levels in rheumatoid arthritis

  • Original Article
  • Published:
Rheumatology International Aims and scope Submit manuscript

Abstract

High myeloperoxidase (MPO) serum levels have been shown in several inflammatory diseases, including rheumatoid arthritis (RA). However, the correlation between MPO levels and disease activity in RA patients is still controversial. The aim of the study was to determine MPO plasma levels in RA patients and to investigate potential correlations between MPO levels and disease activity and treatment. MPO plasma levels were measured by ELISA according the manufacturer’s instructions. Disease activity was measured by DAS28 ESR and DAS28 CRP scores, and patients were classified into 4 groups: group 1 DAS28 < 2.6; group 2: 2.6 ≤ DAS28 ≤ 3.2; group 3: 3.2 < DAS28 ≤ 5.1 and group 4: DAS28 > 5.1. Rheumatoid factor (RF) was measured by latex agglutination test, and anti-cyclic citrullinated peptide (anti-CCP) antibodies were detected by ELISA with a commercial kit. Fifty-seven female RA patients (mean age: 46.02 ± 13.47 years, mean disease duration: 115.77 ± 99.44 months) and sixty gender- and age-paired healthy controls were included. Mean MPO plasma levels were significantly higher in patients than in controls (72.27 pM vs. 40.78 pM, P = 0.007). RF was found in 59.6% and anti-CCP in 80.7% of the RA patients. No significant difference in MPO levels was seen among the four RA disease activity groups. We did not find significant correlation between MPO levels and disease activity as measured by DAS28 score. In conclusion, we observed significantly higher MPO plasma levels in RA patients when compared to healthy controls. However, we did not find correlation between MPO plasma level and disease activity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (Canada)

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Turesson C, Matteson EL (2006) Genetics of rheumatoid arthritis. Mayo Clin Proc 81(1):94–101

    Article  PubMed  CAS  Google Scholar 

  2. Malech HL, Gallin J (1987) Neutrophils in human diseases. N Engl J Med 317:687–694

    Article  PubMed  CAS  Google Scholar 

  3. Lefkowitz DL, Mills K, Lefkowitz SS, Bollen A, Moguilevsky N (1995) Neutrophil-macrophage interaction: a paradigm for chronic inflammation. Med Hypotheses 44:58–62

    Article  PubMed  CAS  Google Scholar 

  4. Lefkowitz DL, Lefkowitz SS (2001) Macrophage-neutrophil interaction: a paradigm for chronic inflammation revisited. Immunol Cell Biol 79:502–506

    Article  PubMed  CAS  Google Scholar 

  5. Brennan M-L, Penn MS, Van Lent F et al (2003) Prognostic value of myeloperoxidase in patients with chest pain. N Engl J Med 349:1595–1604

    Article  PubMed  CAS  Google Scholar 

  6. Torsteinsdóttir I, Hakansson L, Hällgren R, Gudbjörnsson B, Arvidson NG, Venge P (1999) Serum lysozyme: a potential marker of monocyte/macrophage activity in rheumatoid arthritis. Rheumatology (Oxford) 38:1249–1254

    Article  Google Scholar 

  7. Milovanovic M, Nilsson E, Järemo P (2004) Relationships between platelets and inflammatory markers in rheumatoid arthritis. Clin Chim Acta 343:237–240

    Article  PubMed  CAS  Google Scholar 

  8. Minohara M, Matsuoka T, Li W et al (2006) Upregulation of myeloperoxidase in patients with opticospinal multiple sclerosis: positive correlation with disease severity. J Neuroimmunol 178:156–160

    Article  PubMed  CAS  Google Scholar 

  9. Baskol G, Demir H, Baskol M et al (2006) Investigation of protein oxidation and lipid peroxidation in patients with rheumatoid arthritis. Cell Biochem Funct 24:307–311

    Article  PubMed  CAS  Google Scholar 

  10. Accardo-Palumbo A, Triolo G, Carbone MC et al (2000) Polymorphonuclear leukocyte myeloperoxidase levels in patients with Behçet`s disease. Clin Exp Rheumatol 18:495–498

    PubMed  CAS  Google Scholar 

  11. Baldus S, Heeschen C, Meinertz T et al (2003) Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes. Circulation 108:1440–1445

    Article  PubMed  CAS  Google Scholar 

  12. Arnet FC, Edworthy SM, Bloch DA et al (1988) The American rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315–324

    Article  Google Scholar 

  13. Prevoo ML, Van Gestel AM, Van′t Hof MA, Van Rijswijk MH, Van de Putte LB, Van Riel PL (1996) Remission in a prospective study of patients with rheumatoid arthritis. American rheumatism association preliminary remission criteria in relation to the disease activity score. Br J Rheumatol 35:1101–1105

    Article  PubMed  CAS  Google Scholar 

  14. Prevoo MLL, Van′t Hof MA, Van Leeuwen MA, Pute LB, Van Riel PL (1995) Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum 38:44–48

    Article  PubMed  CAS  Google Scholar 

  15. Van Gestel AM, Haagsma CJ, van Riel PLCM (1998) Validation of rheumatoid arthritis improvement criteria that includes simplified joint counts. Arthritis Rheum 41:1845–1850

    Article  PubMed  Google Scholar 

  16. Costa D, Moutinho L, Lima JLFC, Fernandes E (2006) Antioxidant activity and inhibition of human neutrophil oxidative burst mediated by arylpropionic acid non-steroidal anti-inflammatory drugs. Biol. Pharm. Bull 29:1659–1670

    Article  PubMed  CAS  Google Scholar 

  17. Wildfeuer A (1984) Effect of anti-rheumatic drugs on the release of lysosomal enzymes from human leukocytes. Z Rheumatol 43:23–26

    PubMed  CAS  Google Scholar 

  18. Lau D, Mollnau H, Eiserich JP et al (2005) Myeloperoxidase mediates neutrophil activation by association with CD11b/CD18 integrins. Proc Natl Acad Sci 102(2):431–436

    Article  PubMed  CAS  Google Scholar 

  19. Telles RW, Ferreira GA, Silva NP, Sato EI (2010) Increased plasma myeloperoxidase levels in systemic lupus erythematosus. Rheumatol Int 30:779–784

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

We are grateful to the state of São Paulo Research Foundation (FAPESP) for partial financial support (Grants number 2004/11125-0).

Author information

Authors and Affiliations

  1. Brazilian Society of Rheumatology, Piauí, Brazil

    Raissa Maria Sampaio Neves Fernandes

  2. Rheumatology Division, Universidade Federal de São Paulo, Rua Botucatu, 740, São Paulo, 04023 900, Brazil

    Neusa Pereira da Silva & Emília Inoue Sato

Authors
  1. Raissa Maria Sampaio Neves Fernandes
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Neusa Pereira da Silva
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Emília Inoue Sato
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Emília Inoue Sato.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fernandes, R.M.S.N., Silva, N.P.d. & Sato, E.I. Increased myeloperoxidase plasma levels in rheumatoid arthritis. Rheumatol Int 32, 1605–1609 (2012). https://doi.org/10.1007/s00296-011-1810-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00296-011-1810-5

Keywords

Search

Navigation