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Detection of influenza virus: traditional approaches and development of biosensors

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Abstract

Influenza is an acute respiratory disease caused by the influenza virus. The disease occurs annually, causing fatality in the elderly and children and billions of dollars loss in business and productivity. Traditional viral detection methods include MDCK cell culture, complement fixation, hemagglutinin-inhibition, and recently RT-PCR. Although effective, these methods generally involve labor-intensive laboratory procedures and often require trained personnel to carry them out. The development of biosensor technologies will enable rapid and specific disease diagnosis on-site so that a clinician can quickly determine whether treatment is needed. This paper reviews traditional viral assays and progress in the biosensor development for influenza virus. Recent advances in single-step direct detection using non-labeling techniques such as surface plasmon resonance, quartz-crystal microbalance, and colorimetric functional polymers are discussed.

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References

  1. Yohannes K, Roche P, Spencer J, Hampson A (2003) Commun Dis Intell 27:162–172

    PubMed  Google Scholar 

  2. Potter CW (2001) J Appl Microbiol 91:572–579

    Article  CAS  PubMed  Google Scholar 

  3. Sarubbi FA (2003) South Med J 96:735–736

    Article  PubMed  Google Scholar 

  4. Laver G, Garman E (2001) Science 293:1776–1777

    Article  CAS  PubMed  Google Scholar 

  5. Portela A, Digard P (2002) J Gen Virol 83:723–734

    CAS  PubMed  Google Scholar 

  6. Horimoto T, Kawaoka Y (2001) Clin Microbiol Rev 14:129–149

    Article  CAS  PubMed  Google Scholar 

  7. Lin YP, Shaw M, Gregory V, Cameron K, Lim W, Klimov A, Subbarao K, Guan Y, Krauss S, Shortridge K, Webster R, Cox N, Hay A (2000) Proc Natl Acad Sci USA 97:9654–9658

    Article  CAS  PubMed  Google Scholar 

  8. Webby RJ, Webster RG (2003) Science 302:1519–1522

    Article  CAS  PubMed  Google Scholar 

  9. Mitnaul LJ, Matrosovich MN, Castrucci MR, Tuzikov AB, Bovin NV, Kobasa D, Kawaoka Y (2000) J Virol 74:6015–6020

    Article  CAS  PubMed  Google Scholar 

  10. Linde A (2001) Antiviral Res 51:81–94

    Article  CAS  PubMed  Google Scholar 

  11. Woods JM, Bethell RC, Coates JA, Healy N, Hiscox SA, Pearson BA, Ryan DM, Ticehurst J, Tilling J, Walcott SM et al (1993) Antimicrob Agents Chemother 37:1473–1479

    CAS  PubMed  Google Scholar 

  12. Laver WG, Bischofberger N, Webster RG (1999) Sci Am 280:78–87

    CAS  PubMed  Google Scholar 

  13. Skehel JJ, Wiley DC (2000) Annu Rev Biochem 69:531–569

    Article  CAS  PubMed  Google Scholar 

  14. Donatelli I, Campitelli L, Puzelli S, Affinito C, De Marco MA, Delogu M, Barigazzi G (2003) Vet Res Commun Suppl 1:115–122

    Article  Google Scholar 

  15. Colman PM, Varghese JN, Laver WG (1983) Nature 303:41–44

    Article  CAS  PubMed  Google Scholar 

  16. McKimm-Breschkin JL (2002) Expert Opin Pharmacother 3:103–112

    CAS  PubMed  Google Scholar 

  17. Gubareva LV, Kaiser L, Hayden FG (2000) Lancet 355:827–835

    Article  CAS  PubMed  Google Scholar 

  18. Gubareva LV, Webster RG (1999) Infect Med 16:345–354

    Google Scholar 

  19. Stiver G (2003) CMAJ 168:49–56

    PubMed  Google Scholar 

  20. Kashiwagi S (2003) Nippon Rinsho 61:1963–1966

    PubMed  Google Scholar 

  21. Stamboulian D, Bonvehi PE, Nacinovich FM, Cox N (2000) Infect Dis Clin North Am 14:141–166

    CAS  PubMed  Google Scholar 

  22. Boon AC, French AM, Fleming DM, Zambon MC (2001) J Med Virol 65:163–170

    CAS  PubMed  Google Scholar 

  23. Sato S, Ochiai H, Niwayama S (1988) J Med Virol 24:395–404

    CAS  PubMed  Google Scholar 

  24. Prince HE, Leber AL (2003) Clin Diagn Lab Immunol 10:481–482

    Article  CAS  PubMed  Google Scholar 

  25. Yamane N, Yuki M, Nakamura Y (1983) J Clin Microbiol 18:837–843

    CAS  PubMed  Google Scholar 

  26. Sato S, Motoda S, Iwase I, Jo K (1983) J Virol Methods 7:57–64

    Article  CAS  PubMed  Google Scholar 

  27. Heinen P (2002) Veterinary sciences tomorrow 1–11

  28. Zhang WD, Evans DH (1991) J Virol Methods 33:165–189

    Article  CAS  PubMed  Google Scholar 

  29. Murray PR, Baron EJ, Jorgensen JH, Pfaller MA, Yoken RH (2003) Manual of clinical microbiology. ASM Press, Washington

  30. Atmar RL, Baxter BD, Dominguez EA, Taber LH (1996) J Clin Microbiol 34:2604–2606

    CAS  PubMed  Google Scholar 

  31. Ellis JS, Zambon MC (2002) Rev Med Virol 12:375–389

    Article  CAS  PubMed  Google Scholar 

  32. Magnard C, Valette M, Aymard M, Lina B (1999) J Med Virol 59:215–220

    Article  CAS  PubMed  Google Scholar 

  33. Masihi KN, Lange W (1980) J Immunol Methods 36:173–179

    Article  CAS  PubMed  Google Scholar 

  34. Montalto NJ (2003) Am Fam Physician 67:111–118

    PubMed  Google Scholar 

  35. Poehling KA, Griffin MR, Dittus RS, Tang YW, Holland K, Li H, Edwards KM (2002) Pediatrics 110:83–88

    Article  PubMed  Google Scholar 

  36. Covalciuc KA, Webb KH, Carlson CA (1999) J Clin Microbiol 37:3971–3974

    CAS  PubMed  Google Scholar 

  37. Reina J, Padilla E, Alonso F, Ruiz De Gopegui E, Munar M, Mari M (2002) J Clin Microbiol 40:3515–3517

    Article  CAS  PubMed  Google Scholar 

  38. Cazacu AC, Greer J, Taherivand M, Demmler GJ (2003) J Clin Microbiol 41:2132–2134

    Article  CAS  PubMed  Google Scholar 

  39. Quach C, Newby D, Daoust G, Rubin E, McDonald J (2002) Clin Diagn Lab Immunol 9:925–926

    Article  PubMed  Google Scholar 

  40. Bellei N, Benfica D, Perosa AH, Carlucci R, Barros M, Granato C (2003) J Virol Methods 109:85–88

    Article  CAS  PubMed  Google Scholar 

  41. Shimasaki CD, Achyuthan KE, Hansjergen JA, Appleman JR (2001) Philos Trans R Soc Lond B Biol Sci 356:1925–1931

    Article  CAS  PubMed  Google Scholar 

  42. Shimizu H (2000) Nippon Rinsho 58:2234–2237

    CAS  PubMed  Google Scholar 

  43. Schultze D, Thomas Y, Wunderli W (2001) Eur J Clin Microbiol Infect Dis 20:280–283

    Article  CAS  PubMed  Google Scholar 

  44. Hindiyeh M, Goulding C, Morgan H, Kenyon B, Langer J, Fox L, Dean G, Woolstenhulme D, Turnbow A, Billetdeaux E, Shakib S, Gordon C, Powers A, Vardeny G, Johnson M, Skodack-Jones L, Carroll K (2000) J Clin Virol 17:119–126

    Article  CAS  PubMed  Google Scholar 

  45. (2001) Sensors Update 9:313–354

  46. Cooper MA, Dultsev FN, Minson T, Ostanin VP, Abell C, Klenerman D (2001) Nat Biotechnol 19:833–837

    Article  CAS  PubMed  Google Scholar 

  47. Sato T, Serizawa T, Okahata Y (1996) Biochim Biophys Acta 1285:14–20

    CAS  PubMed  Google Scholar 

  48. Sato T, Ishii M, Ohtake F, Nagata K, Terabayashi T, Kawanishi Y, Okahata Y (1999) Glycoconj J 16:223–227

    Article  CAS  PubMed  Google Scholar 

  49. Eun AJ, Huang L, Chew FT, Li SF, Wong SM (2002) J Virol Methods 99:71–79

    Article  CAS  PubMed  Google Scholar 

  50. Su CC, Wu TZ, Chenb LK, Yang HH, Tai DF (2003) Anal Chim Acta 479:117–123

    Article  CAS  Google Scholar 

  51. Uttenthaler E, Schraml M, Mandel J, Drost S (2001) Biosens Bioelectron 16:735–743

    Article  CAS  PubMed  Google Scholar 

  52. Homola J (2003) Anal Bioanal Chem 377:528–539

    Article  CAS  PubMed  Google Scholar 

  53. Cooper MA (2003) Anal Bioanal Chem 377:834–842

    Article  CAS  PubMed  Google Scholar 

  54. Sambles JR, Bradbery GW, Yang F (1991) Contemp Phys 32:173–183

    CAS  Google Scholar 

  55. Mullett WM, Lai EP, Yeung JM (2000) Methods 22:77–91

    Article  CAS  PubMed  Google Scholar 

  56. Schofield DJ, Dimmock NJ (1996) J Virol Methods 62:33–42

    Article  CAS  PubMed  Google Scholar 

  57. Critchley P, Dimmock NJ (2004) Bioorg Med Chem 12:2773–2780

    Article  CAS  PubMed  Google Scholar 

  58. Boltovets PM, Boyko VR, Kostikov IY, Dyachenko NS, Snopok BA, Shirshov YM (2002) J Virol Methods 105:141–146

    Article  CAS  PubMed  Google Scholar 

  59. Hardy SA, Dimmock NJ (2003) J Virol 77:1649–1652

    Article  CAS  PubMed  Google Scholar 

  60. Gruen LC, McKimm-Breschkin JL, Caldwell JB, Nice EC (1994) J Immunol Methods 168:91–100

    Article  CAS  PubMed  Google Scholar 

  61. Gruen LC, Kortt AA, Nice E (1993) Eur J Biochem 217:319–325

    CAS  PubMed  Google Scholar 

  62. Takemoto DK, Skehel JJ, Wiley DC (1996) Virology 217:452–458

    Article  CAS  PubMed  Google Scholar 

  63. Kortt AA, Nice E, Gruen LC (1999) Anal Biochem 273:133–141

    Article  CAS  PubMed  Google Scholar 

  64. Nice EC, McInerney TL, Jackson DC (1996) Mol Immunol 33:659–670

    Article  CAS  PubMed  Google Scholar 

  65. Charych D, Cheng Q, Reichert A, Kuziemko G, Stroh M, Nagy JO, Spevak W, Stevens RC (1996) Chem Biol 3:113–120

    Article  CAS  PubMed  Google Scholar 

  66. Bernier S, Garreau S, Bera-Aberem M, Gravel C, Leclerc M (2002) J Am Chem Soc 124:12463–12468

    Article  CAS  PubMed  Google Scholar 

  67. Kolusheva S, Kafri R, Katz M, Jelinek R (2001) J Am Chem Soc 123:417–422

    Article  CAS  PubMed  Google Scholar 

  68. Lu Y, Yang Y, Sellinger A, Lu M, Huang J, Fan H, Haddad R, Lopez G, Burns AR, Sasaki DY, Shelnutt J, Brinker CJ (2001) Nature 410:913–917

    Article  CAS  PubMed  Google Scholar 

  69. Leclerc M (1999) Adv Mater 11:1491–1498

    Article  CAS  Google Scholar 

  70. Song J, Cheng Q, Zhu S, Stevens RC (2002) Biomed Microdev 4:213–221

    Article  CAS  Google Scholar 

  71. Charych DH, Nagy JO, Spevak W, Bednarski MD (1993) Science 261:585–588

    CAS  PubMed  Google Scholar 

  72. Anke R, Nagy JO, Spevak W, Charych D (1995) J Am Chem Soc 117:829–830

    Google Scholar 

  73. Baek MG, Stevens RC, Charych DH (2000) Bioconjug Chem 11:777–788

    Article  CAS  PubMed  Google Scholar 

  74. Dore K, Dubus S, Ho HA, Levesque I, Brunette M, Corbeil G, Boissinot M, Boivin G, Bergeron MG, Boudreau D, Leclerc M (2004) J Am Chem Soc 126:4240–4244

    Article  CAS  PubMed  Google Scholar 

  75. McKimm-Breschkin JL, Colman PM, Jin B, Krippner GY, McDonald M, Reece PA, Tucker SP, Waddington L, Watson KG, Wu WY (2003) Angew Chem Int Ed Engl 42:3118–3121

    Article  CAS  PubMed  Google Scholar 

  76. Krug RM (2003) Antiviral Res 57(special issue SI):147–150

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

The authors wish to acknowledge financial support from UC Riverside and an Eli Lilly Young Analyst grant.

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  1. Department of Chemistry, University of California, Riverside, CA, 92521, USA

    Yoshihisa Amano & Quan Cheng

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  1. Yoshihisa Amano
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  2. Quan Cheng
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Correspondence to Quan Cheng.

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Amano, Y., Cheng, Q. Detection of influenza virus: traditional approaches and development of biosensors. Anal Bioanal Chem 381, 156–164 (2005). https://doi.org/10.1007/s00216-004-2927-0

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