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Interferon regulatory factor 3 in adaptive immune responses

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Abstract

Interferon regulatory factor (IRF) 3 plays a key role in innate responses against viruses. Indeed, activation of this transcription factor triggers the expression of type I interferons and downstream interferon-stimulated genes in infected cells. Recent evidences indicate that this pathway also modulates adaptive immune responses. This review focuses on the different mechanisms that are implicated in this process. We discuss the role of IRF3 within antigen-presenting cells and T lymphocytes in the polarization of the cellular immune response and its implication in the pathogenesis of immune disorders.

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Acknowledgments

This work has been funded by a grant from the government of the Walloon Region and GlaxoSmithKline Biologicals. VM and SG are supported by the Fonds National de la Recherche Scientifique (FRS-FNRS, Belgium) and an Interuniversity Attraction Pole of the Belgian Federal Science Policy.

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  1. WELBIO and Institute for Medical Immunology (IMI), Université Libre de Bruxelles, 8 rue Adrienne Bolland, 6041, Charleroi-Gosselies, Belgium

    Laure Ysebrant de Lendonck, Valerie Martinet & Stanislas Goriely

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  1. Laure Ysebrant de Lendonck
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  2. Valerie Martinet
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  3. Stanislas Goriely
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Correspondence to Stanislas Goriely.

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Ysebrant de Lendonck, L., Martinet, V. & Goriely, S. Interferon regulatory factor 3 in adaptive immune responses. Cell. Mol. Life Sci. 71, 3873–3883 (2014). https://doi.org/10.1007/s00018-014-1653-9

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  • DOI: https://doi.org/10.1007/s00018-014-1653-9

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