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Virologic and immunologic events in primary HIV infection

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References

  1. Alkhatib G, Combardiere C, Broder CC, Feng Y, Kennedy PE, Murphy P, Berger E (1996) CC CKR5: a RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 272:1955

    Google Scholar 

  2. Armstrong JA, Dawkins RL, Home R (1985) Retroviral infection of accessory cells and the immunological paradox in AIDS. Immunol Today 6:121

    Google Scholar 

  3. Asjo B, Sharma UK, Morfeldt-Manson L, Magnusson A (1990) Naturally occurring HIV-1 isolates with differences in replicative capacity are distinguished by in situ hybridization of infected cells. AIDS Res Hum Retroviruses 6:1177

    Google Scholar 

  4. Borrow P, Lewicki H, Hahn BH, Shaw GM, Oldstone MB (1994) CTL activity associated with control of viremia in primary HIV-1 infection. J Virol 68:6103

    Google Scholar 

  5. Reference deleted

  6. Choe H, Farzan M, Sun Y, Sullivan N, Rollins B, Ponath PD, Wu L, Mackay CR, LaRosa G, Newman W, Gerard N, Gerard C, Sodroski J (1996) Theβ-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 85:1135

    Google Scholar 

  7. Clark SJ, Saag MS, Decker WD, Campbell-Hill S, Roberson JL, Veldkamp PJ, Kappes JC, Hahn BH, Shaw GM (1991) High titers of cytopathic virus in plasma of patients with symptomatic primary HIV-1 infection. N Engl J Med 324:954

    Google Scholar 

  8. Cocchi F, DeVico AL, Garzino-Demo A, Ayra SK, Gallo RC, Lusso P (1996) Identification of RANTES, MIP-1α, and MIP-1β as the major HIV-suppressive factors produced by CD8+ T cells. Science 270:1811

    Google Scholar 

  9. Coffin JM (1995) HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy Science 267:483

    Google Scholar 

  10. Daar ES, Moudgil T, Meyer RD, Ho DD (1991) Transient high levels of viremia in patients with primary human immunodeficiency virus type 1 infection. N Engl J Med 324:961

    Google Scholar 

  11. Deng H, Liu R, Ellmeier W, Choe W, Nutmaz D, Burkhart M, Di Marzio P, Marmon S, Sutton RE, Hill CM, Davis CB, Peiper SC, Schall TJ, Littman DR, Laudau NR (1996) Identification of a major co-receptor for primary isolates of HIV-1. Nature 381:661

    Google Scholar 

  12. Denis M, Ghadirian E (1994)Mycobacterium avium infection in HIV-1-infected subjects increases monokine secretion and is associated with enhanced viral load and diminished immune response to viral antigens. Clin Exp Immunol 97:76–82

    Google Scholar 

  13. Doranz BJ, Rucker J, Yi Y, Smyth RJ, Samson M, Peiper SC, Parmentier M, Collman RG, Doms RW (1996) A dual-tropic primary HIV-1 isolate that uses fusin and the b-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell 85:1149

    Google Scholar 

  14. Dragic T, Litwin V, Allaway GP, Martin SR, Huang Y, Nagashima KA, Cayanan C, Maddon PJ, Koup R, Moore JP, Paxton WA (1996) HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature 381:667

    Google Scholar 

  15. Embretson J, Zupancic M, Ribas JL, Burke A, Tenner-Racz K, Haase AT (1993) Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature 362:359

    Google Scholar 

  16. Emilie D, Peuchmaur M, Maillot M, Crevon M, Brousse N, Delfraissy J, Dormont J, Galanaud P (1990) Production of interleukins in human immunodeficiency virus-1-replicating lymph nodes. J Clin Invest 86:148

    Google Scholar 

  17. Fox CH, Tenner-Racz K, Racz P, Firpo A, Pizzo PA, Fauci AS (1991) Lymphoid germinal centers are reservoirs of human immunodeficiency virus type 1 RNA. J Infect Dis 164:1051

    Google Scholar 

  18. Graziosi C, Pantaleo G, Butini L, Demarest IF, Saag MS, Shaw GM, Fauci AS (1993) Kinetics of HIV DNA and RNA synthesis during primary HIVA infection. Proc Natl Acad Sci USA 90:6505

    Google Scholar 

  19. Graziosi C, Gantt KR, Vaccarezza M, Demarest JF, Daucher MB, Saag MS, Shaw GM, Quinn TC, Cohen OJ, Welbon C, Pantaleo G, Fauci AS (1996) Kinetics of cytokine expression during primary human immunodeficiency virus type 1 (HIV-1) infection. Proc Natl Acad Sci USA, 93:4386

    Google Scholar 

  20. Guidotti LG, Ishikawa T, Hobbs MV, Matzke B, Scrieber, Chisari FV (1996) Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes. Immunity 4:25

    Google Scholar 

  21. Health SL, Tew JG, Szakal AK, Burton GF (1995) Follicular dendritic cells and human immunodeficiency virus. Nature 377:740

    Google Scholar 

  22. Heng MCY, Heng SY, Allen SG (1994) Co-infection and synergy of human immunodeficiency virus-1 and herpes simplex virus-1. Lancet 343:255

    Google Scholar 

  23. Ho DD (1992) HIV-1 viraemia and influenza. Lancet 339:1549

    Google Scholar 

  24. Israel-Biet D, Cadranel J, Even P (1993) Human immunodeficiency virus production by alveolar lymphocytes is increased duringPneumocystis carinii pneumonia. Am Rev Respir Dis 148:1308

    Google Scholar 

  25. Koot M, Keet IP, Vos AH, deGoede RE, Roos MT, Coutinho RA, Miedema F, Schellekens PT, Tersmette M (1993) Prognostic value of HIV-1 syncytium-inducing phenotype for rate of CD4+ cell depletion and progression to AIDS. Ann Intern Med 118:681

    Google Scholar 

  26. Koup RA, Safrit JT, Cao Y, Andrews CA, McLeod G, Ho DD (1994) Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J Virol 68:4650

    Google Scholar 

  27. Mackewicz CF, Ortega HW, Levy JA (1991) CD8+ cell anti-HIV activity correlates with the clinical state of the infected individuals. J Clin Invest 87:1462

    Google Scholar 

  28. Meier UC, Klenerman P, Griffin P, James W, Koppe B, Larder B, McMichael A, Phillips R (1995) Cytotoxic T lymphocyte lysis inhibited by viable HIV mutants. Science 270:1360

    Google Scholar 

  29. Moore JP, Cao Y, Ho DD, Koup RA (1994) Development of the anti-gp120 antibody response during seroconversion to human immunodeficiency, virus type 1. J Virol 68:5142

    Google Scholar 

  30. Pantaleo G, Fauci AS (1995) New concepts in the immunopathogenesis of HIV infection. Annu Rev Immunol 13:487

    Google Scholar 

  31. Pantaleo G, Fauci AS (1996) Immunopathogenesis of HIV infection. Annu Rev Microbiol 50:825

    Google Scholar 

  32. Pantaleo G, Graziosi C, Butini L, Pizzo PA, Schnittman SM, Kotler DP, Fauci AS (1991) Lymphoid organs function as major reservoirs for human immunodeficiency virus. Proc Natl Acad Sci USA 88:9838

    Google Scholar 

  33. Pantaleo G, Graziosi C, Demarest IF, Butini L, Montroni M, Fox CH, Orenstein JM, Kotler DP, Fauci AS (1993) HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature 362:355

    Google Scholar 

  34. Pantaleo G, Graziosi C, Fauci AS (1993) The role of lymphoid organs in the pathogenesis of HIV infection. Semin Immunol 5:157

    Google Scholar 

  35. Pantaleo G, Graziosi C, Fauci AS (1993) The role of lymphoid organs in the immunopathogenesis of HIV infection. AIDS 7:S19

    Google Scholar 

  36. Pantaleo G, Demarest JF, Soudeyns H, Graziosi C, Denis F, Saag M, Shaw GM, Sekaly RP, Fauci AS (1994) Major expansion of CD8+ T cells with a predominant Vβ usage during the primary immune response of HIV. Nature 370:463

    Google Scholar 

  37. Pantaleo G, Graziosi C, Demarest IF, Cohen OJ, Vaccarezza M, Muro-Cacho C, Fauci AS (1994) Role of lymphoid organs in the pathogenesis of human immunodeficiency virus (HIV) infection. Immunol Rev 140:105

    Google Scholar 

  38. Pantaleo G, Demarest JF, Schacker T, Vaccarezza M, Cohen OJ, Daucher MB, Graziosi C, Schnittman SM, Quinn TC, Shaw GM, Perrin L, Tambussi G, Lazzarin A, Sekaly RP, Soudeyns H, Corey L, Fauci AS (1997) The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia. Proc Natl Acad Sci USA 94:254

    Google Scholar 

  39. Philips RE, Rowland-Jones S, Nixon DF, Gotch FM, Edwards JP, Ogunlesi AO, Elvin JG, Rothbard JA, Bangham CR, Rizza CR, McMichael A (1991) Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition. Nature 354:453

    Google Scholar 

  40. Reimann KA, Tenner-Racz K, Racz P, Montefiori DC, Yasutomi Y, Letvin NL (1994). Immunopathogenic events in acute infection of Rhesus monkeys with simian immunodeficiency virus of Macaques. J Virol 68:2362

    Google Scholar 

  41. Schellekens PT, Tersmette M, Roos MT, Keet RP, Wolf F de, Coutinho RA, Miedema F (1992) Biphasic rate of CD4+ cell count decline during progression to AIDS correlates with HIV-1 phenotype. AIDS 6:665

    Google Scholar 

  42. Schuitemaker H, Koot M, Koostra NA, Dercksen MW, Goede REY de, Steenwijk RP van, Lange JM, Schattenkerk JK, Miedema F, Tersmette M (1992) Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population. J Virol 66:1354

    Google Scholar 

  43. Spiegel H, Herbst H, Niedobitek G, Foss HD, Stein H (1992) Follicular dendritic cells are a major reservoir for human immunodeficiency virus type 1 in lymphoid tissues facilitating infection of CD4+ T-helper cells. Am J Pathol 140:15

    Google Scholar 

  44. Tenner-Racz K, Racz P, Dietrich M, Karin P (1985) Altered follicular dendritic cells and virus-like particles in AIDS and AIDS related lymphadenopathy. Lancet 1:105

    Google Scholar 

  45. Tersmette M, Goede RE de, Al BJ, Winkel IN, Gruters RA, Cuypers HT, Huisman HG, Miedema F (1988) Differential syncytium-inducing capacity of human immunodeficiency virus isolates: frequent detection of syncytium-inducing isolates in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. J Virol 62:2026

    Google Scholar 

  46. Tersmette M, Gruters RA, Wolf F de, Goede RE de, Lange JM, Schellekens PT, Goudsmit J, Huisman HG, Miedema F (1989) Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency syndrome: sudies on sequential HIV isolates. J Virol 63:2118

    Google Scholar 

  47. Tindall B, Cooper DA (1991) Primary HIV infection: host responses and intervention strategies. AIDS 5:1

    Google Scholar 

  48. Zhang Y, Nakata K, Weiden M, Rom WN (1995)Mycobacterium tuberculosis enhances human immunodeficiency virus-1 replication by transcriptional activation at the long terminal repeat. J Clin Invest 95:2324

    Google Scholar 

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Pantaleo, G., Graziosi, C. & Fauci, A.S. Virologic and immunologic events in primary HIV infection. Springer Semin Immunopathol 18, 257–266 (1997). https://doi.org/10.1007/BF00813497

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