Summary
4,4′-(3,7,12,16-Tetramethyl-1,3,5,7,9,11,13, 15,17-octadecanonaen-1,18-diyl) bis (1-ethylpyridinium) dibromide (Y-18598), a novel carotenoid analog with 1-ethylpyridine rings as terminal groups, was found to be effective against P388 leukemia which was refractory to amphotericin B and retinoic acid used as representatives of polyene-containing drugs. The life span of leukemic mice was increased by 56% over the control following administration of 2.5 mg/kg on days 1–5. Among these polyene-containing compounds, Y-18598 was the most highly cytotoxic to P388 leukemia cells in vitro.
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Okumoto, T., Morita, N., Nakamura, I. et al. Activity of a novel carotenoid analog, 4,4′-(3,7,12,16-Tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaen-1,18-diyl) bis(1-ethylpyridinium) dibromide (Y-18598) on mouse leukemia P388. J Cancer Res Clin Oncol 109, 257–259 (1985). https://doi.org/10.1007/BF00390366
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DOI: https://doi.org/10.1007/BF00390366