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Sumoylation of hypoxia inducible factor-1α and its significance in cancer

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  • Published: 11 June 2014
  • Volume 57, pages 657–664, (2014)
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Science China Life Sciences Aims and scope Submit manuscript
Sumoylation of hypoxia inducible factor-1α and its significance in cancer
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  • Jie Li1,
  • Ying Xu2,
  • HuiKe Jiao2,
  • Wei Wang1,
  • Zhu Mei1 &
  • …
  • GuoQiang Chen1,2 

  • 2133 Accesses

  • 19 Citations

  • Explore all metrics

Abstract

Hypoxia-inducible factor-1 (HIF-1) is a key heterodimeric transcription factor for the cellular adaptive response to hypoxia, a common feature of the microenvironment in solid tumors. The transcriptional activity, protein stabilization, protein-protein interactions and cellular localization of HIF-1α, an oxygen-sensitive subunit of HIF-1, are mainly modulated by various post-translational modifications. Recently, we reported that polycomb chromobox 4 (Cbx4) governs the transcriptional activity of HIF-1α by enhancing its sumoylation at K391 and K477, through which Cbx4 potentiates angiogenesis of hepatocellular carcinoma. This review summarizes the current knowledge of HIF-1α sumoylation and its roles in the pathogenesis of cancer.

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Authors and Affiliations

  1. Department of Pathophysiology, Chemical Biology Division of Shanghai Universities E-Institutes, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China

    Jie Li, Wei Wang, Zhu Mei & GuoQiang Chen

  2. Institute of Health Sciences, Shanghai Institutes for Biological Sciences of Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China

    Ying Xu, HuiKe Jiao & GuoQiang Chen

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  1. Jie Li
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Correspondence to GuoQiang Chen.

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Li, J., Xu, Y., Jiao, H. et al. Sumoylation of hypoxia inducible factor-1α and its significance in cancer. Sci. China Life Sci. 57, 657–664 (2014). https://doi.org/10.1007/s11427-014-4685-3

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  • Received: 22 March 2014

  • Accepted: 15 April 2014

  • Published: 11 June 2014

  • Issue Date: July 2014

  • DOI: https://doi.org/10.1007/s11427-014-4685-3

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Keywords

  • HIF-1α
  • sumoylation
  • cancer
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