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Effects of immunostimulation with OK432, coenzyme Q10, or levamisole on dimethylhydrazine-induced colonic carcinogenesis in rats

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Abstract

Effects of immunostimulation with OK432, Coenzyme Q10 (Co-Q10), or levamisole on dimethylhydrazine (DMH)-induced colonic carcinogenesis were investigated in 45 Donryu-rats. The manipulation with one of these immunopotentiators did not prevent DMH-induced colonic carcinogenesis in these rats. However, the number of tumors was significantly reduced and the incidence of invasive carcinomas decreased by immunostimulation. The treatment also reduced the number of lesions with epithelial dysplasia within the flat colonic mucosa.

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Authors and Affiliations

  1. The Second Department of Surgery, Mie University School of Medicine, 2-174 Edobashi, 514, Tsu, Japan

    Hiroshi Suzuki MD, Junji Yamamoto, Yasushi Iwata, Koichi Matsumoto & Keiji Iriyama

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  1. Hiroshi Suzuki MD
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  2. Junji Yamamoto
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  3. Yasushi Iwata
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  4. Koichi Matsumoto
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  5. Keiji Iriyama
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Suzuki, H., Yamamoto, J., Iwata, Y. et al. Effects of immunostimulation with OK432, coenzyme Q10, or levamisole on dimethylhydrazine-induced colonic carcinogenesis in rats. The Japanese Journal of Surgery 16, 152–155 (1986). https://doi.org/10.1007/BF02471087

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  • DOI: https://doi.org/10.1007/BF02471087

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