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Tumorigenic activity of cloned polyoma virus DNA in newborn rats

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Summary

The proximal portion of the polyoma virus early region as well as the complete viral genome were cloned in pBR322. Recombinant plasmids induced tumors in newborn rats but only after linearization of the DNA by various restriction endonucleases.

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Author information

Authors and Affiliations

  1. Département de Microbiologie, Centre Hospitalier Universitaire, Université de Sherbrooke, J1H 5N4, Sherbrooke, Québec, Canada

    C. Gélinas, L. Bouchard & M. Bastin

Authors
  1. C. Gélinas
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  2. L. Bouchard
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  3. M. Bastin
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Additional information

This work was financed by grant MA-6731 from the Medical Research Council and by a grant from the National Cancer Institute of Canada.

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Gélinas, C., Bouchard, L. & Bastin, M. Tumorigenic activity of cloned polyoma virus DNA in newborn rats. Experientia 37, 1074–1075 (1981). https://doi.org/10.1007/BF02085017

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