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Isolation and characterization of lipocortin (lipomodulin)

  • Corticosteroid Actions in Infalmmation
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Summary

Lipocortin is a phospholipase inhibitory protein whose synthesis is induced in various cells by glucocorticoids. At least three species with molecular weights of 40,000, 30,000, and 15,000 are presently known. This protein mimics the anti-inflammatory action of glucocorticoidsin vitro as well asin vivo. The synthesis of the protein appears to be associated with the MHC genes.

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Authors and Affiliations

  1. Laboratory of Cell Biology, National Institute of Mental Health, 20205, Bethesda, Maryland, USA

    Fusao Hirata, Yoshitada Notsu, Ryo Yamada, Yoko Ishihara, Yuji Wano, Ildiko Kunos & George Kunos

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  1. Fusao Hirata
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  2. Yoshitada Notsu
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  3. Ryo Yamada
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  4. Yoko Ishihara
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  5. Yuji Wano
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  6. Ildiko Kunos
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  7. George Kunos
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Hirata, F., Notsu, Y., Yamada, R. et al. Isolation and characterization of lipocortin (lipomodulin). Agents and Actions 17, 263–266 (1986). https://doi.org/10.1007/BF01982617

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