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Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4

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An Erratum to this article was published on 15 July 1989

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Summary

The African treeCombretum caffrum (Combretaceae) has been found to contain a powerful inhibitor of tubulin polymerization (IC502–3 μM), the growth of murine lymphocytic leukemia (L 1210 and P 388 with ED50≈0.003 μM and human colon cancer cell lines [(e.g. LoVo (ED50=0.005 μg/ml), HT29 (ED50 0.02 μg/ml, Colo 205 (ED50=0.07 μg/ml), DLD-1 (ED50=0.005 μg/ml) and HCT-15 (ED50=0.0009 μg/ml)] designated combretastatin A-4 (1c). The structure assigned by spectral techniques was confirmed by synthesis.

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References

  1. Pettit, G. R., Cragg, G. M., Herald, D. L., Schmidt, J. M., and Lohavanijaya, P., Can. j. Chem.60 (1982) 1374.

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  6. Predicatble (ref. 4,5)1H-and13C-NMR, infrared and mass spectral data, as well as acceptable elemental analyses, were obtained for each new compound.

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Authors and Affiliations

  1. Cancer Research Institute and Department of Chemistry, Arizona State University, 85287, Tempe, Arizona, USA

    G. R. Pettit & S. B. Singh

  2. Laboratory of Pharmacology and Experimental Therapeutics, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institutes of Health, 20892, Bethesda, Maryland, USA

    E. Hamel & C. M. Lin

  3. University of Arizonc, 85724, Tucson, Arizona, USA

    D. S. Alberts & D. Garcia-Kendal

Authors
  1. G. R. Pettit
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  2. S. B. Singh
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  3. E. Hamel
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  4. C. M. Lin
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  5. D. S. Alberts
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  6. D. Garcia-Kendal
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Additional information

For the preceding part (145) of the series Antineoplastic Agents refer to: H. Hennings, P. M. Blumberg, G. R. Pettit, C. L. Herald, R. Shores and S. H. Yuspa,Carcinogenesis, in press.

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Pettit, G.R., Singh, S.B., Hamel, E. et al. Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4. Experientia 45, 209–211 (1989). https://doi.org/10.1007/BF01954881

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  • DOI: https://doi.org/10.1007/BF01954881

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