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Transforming growth factor beta (TGF-β) in inflammation: A cause and a cure

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References

  1. Roberts AB, Sporn MB: The transforming growth factor βs. Handbk Exp Pharm 95:419–458, 1990

    Google Scholar 

  2. Wahl SM, McCartney-Francis N, Mergenhagen SE: Inflammatory and immunomodulatory role of transforming growth factor beta. Immunol Today 10:258–261, 1989

    Google Scholar 

  3. Derynck R, Jarett JA, Chen EY, Eaton DH, Bell JR, Assoian K, Roberts AB, Sporn MB, Goeddel DV: Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells. Nature 316:701, 1985

    Google Scholar 

  4. Kim SJ, Denhez F, Kim KY, Holt JT, Sporn MB, Roberts AB: Activation of the second promoter of the transforming growth factor β1 gene by transforming growth factor β1 and phorbol ester occurs through the same target sequences. J Biol Chem 264:19373–19378, 1989

    Google Scholar 

  5. Kim SJ, Jeang KT, Glick A, Sporn MB, Roberts AB: Promoter sequences of the human transforming growth factor-β1 gene responsive to transforming growth factor-β1 autoinduction. J Biol Chem 264:7041–7045, 1989

    Google Scholar 

  6. Kim SJ, Angel P, Lafyatis R, Hattori K, Kim KY, Sporn MB, Karin M, Roberts AB: Autoinduction of transforming growth factor β1 is mediated by the AP-1 complex. Mol Cell Biol 10:1492–1497, 1990

    Google Scholar 

  7. Wakefield LM, Smith DM, Falanders KC, Sporn MB: Latent transforming growth factor-β from human platelets. A high molecular weight complex containing precursor sequences. J Biol Chem 263:7646, 1988

    Google Scholar 

  8. Ruoslahti E, Pierschbacher MD: Arg-Gly-Asp: A versatile cell recognition signal. Cell 44:517–578, 1986

    Google Scholar 

  9. Nathan C, Sporn M: Cytokines in context: J Cell Biol 113:981–986, 1991

    Google Scholar 

  10. Wakefield LM, Smith DM, Masui T, Harris CC, Sporn MB: Distribution and modulation of the cellular receptor for transforming growth factor-beta. J Cell Biol 105:965, 1987

    Google Scholar 

  11. Miyazano K, Heldin CH: Interaction between TGF-β1 and carbohydrate structures in its precursor renders TGF-β1 latent. Nature 338:158–160, 1989

    Google Scholar 

  12. Dennis PA, Rifkin DB: Cellular activation of latent transforming growth factor β requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor. Cell Biol 88:580–584, 1991

    Google Scholar 

  13. Lyons RM, Keski-Oja J, Moses HL: Proteolytic activation of latent transforming growth factor-β from fibroblast-conditioned medium. J Cell Biol 106:1659–1665, 1988

    Google Scholar 

  14. Twardzik DR, Mikovits JA, Ranchalis JE, Purchio AF, Ellingsworth L, Ruscetti FW: γ-Interferon-induced activation of latent transforming growth factor-β by human monocytes.In Transforming Growth Factor-βs: Chemistry, Biology, and Therapeutics, KA Piez, MB Sporn (eds). New York, New York Academy of Sciences, 1990, p 276

    Google Scholar 

  15. Wahl SM, Allen JB, Wong HL, Dougherty SF, Ellingsworth LR: Antagonistic and agonistic effects of transforming growth factor-β and IL-1 in rheumatoid synovium. J Immunol 145:2514–2519, 1990

    Google Scholar 

  16. Pilatte Y, Bignon J, Lambre CR: Lysosomal and cytosolic sialidases in rabbit alveolar macrophages: Demonstration of increased lysosmal activity after in vivo activation with bacillus Calmette Guerin. Biochim Biophys Acta 923:150, 1987

    Google Scholar 

  17. Silver IA, Murrills RJ, Etherington DJ: Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts. Exp Cell Res 175:266, 1988

    Google Scholar 

  18. Wakefield LM, Winokur TS, Hollands RS, Christopherson K, Levinson AD, Sporn MB: Recombinant latent transforming growth factor β1 has a longer plasma half-life in rats than active transforming growth factor β1, and a different tissue distribution. J Clin Invest 86:1976–1984, 1991

    Google Scholar 

  19. Assoian RK, Komoriya A, Meyers CA, Miller DM, Sporn MB: Transforming growth factor-beta in human platelets. J Biol Chem 258:7155–7160, 1983

    Google Scholar 

  20. Van den Eijnden-van Raaij AJM, Koornneef I, van Zoelen EJJ: A new method for high yield purification of type beta transforming growth factor from human platelets. Biochem Biophys Res Commun 157:16–23, 1988

    Google Scholar 

  21. Wahl SM, Hunt DA, Wakefield L, McCartney-Francis N, Wahl LM, Roberts AB, Sporn MB: Transforming growth factor beta (TGF-β) induces monocyte chemotaxis and growth factor production. Proc Natl Acad Sci 84:5788–5792, 1987

    Google Scholar 

  22. Brandes ME, Mai UEH, Ohura K, Wahl SM: Human neutrophils express type I TGF-β receptors and chemotax to TGF-β. J Immunol 147:1600–1606, 1991

    Google Scholar 

  23. Fava RA, Olsen NJ, Postlethwaite AE, Broadley KN, Davidson JM, Nanney LB, Lucas C, Townes AS: Transforming growth factor β1 (TGF-β1) induced neutrophil recruitment to synovial tissues: Implications for TGF-β-driven synovial inflammation and hyperplasia. J Exp Med 173:1121–1132, 1991

    Google Scholar 

  24. Reibman J, Meisler S, Lee TC, Gold LI, Cronstein BN, Haines KA, Kolasinski SL, Weissmann GW: Transforming growth factor β1, a potent chemoattractant for human neutrophils, bypasses classic signal-transduction pathways. Proc Natl Acad Sci 85:6805–6809, 1991

    Google Scholar 

  25. Adams DH, Hathaway M, Shaw J, Burnett D, Elias E, Strain AJ: Transforming growth factor-β induces human T lymphocyte migration in vitro. J Immunol 147:609–612, 1991

    Google Scholar 

  26. Roberts AB, Sporn MB, Assoian RK, Smith JM, Roche NS, Wakefield LM, Heine UI, Liotta LA, Falanga V, Kehrl JH: Transforming growth factor type β: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci 83:4167–4171, 1986

    Google Scholar 

  27. Allen JB, Manthey CL, Hand A, Ohura K, Ellingsworth L, Wahl SM: Rapid onset synovial inflammation and hyperplasia induced by transforming growth factor β. J Exp Med 171:231–247, 1990

    Google Scholar 

  28. Lynch SE, Colvin RB, Antoniades HN: Growth factors in wound healing. J Clin Invest 84:640–646, 1989

    Google Scholar 

  29. Pierce GF, Mustoe TA, Lingelbach J, Masakowski VR, Gramates P, Deuel TF: Transforming growth factor β reverses the glucocorticoid-induced wound-healing deficit in rats: Possible regulation in macrophages by platelet-derived growth factor. Cell Biol 86:2229–2233, 1989

    Google Scholar 

  30. Wahl SM, Allen JB, Weeks BS, Wong HL, Klotman PE: TGF-β enhances integrin expression and Type IV collagenase secretion in human monocytes (submitted for publication), 1992

  31. Wahl SM: Recruitment.In Encyclopedia of Immunology, JM Roitt, PJ Delves (eds). London, WB Saunders, pp 1304–1307, 1991

    Google Scholar 

  32. Ruoslahti E: Integrins. J Clin Invest 81:1–5, 1991

    Google Scholar 

  33. Springer TA: Adhesion receptors of the immune system. Nature 346:425–434, 1990

    Google Scholar 

  34. Gamble JR, Vadas MA: Endothelial adhesiveness for blood neutrophils is inhibited by transforming growth factor-β. Science 242:97, 1988

    Google Scholar 

  35. Ignotz R, Heino J, Massaque J: Regulation of cell adhesion receptors by transforming growth factor β: Regulation of vitronectin receptor and LFA-1. J Biol Chem 264:389, 1989

    Google Scholar 

  36. Fava R, Olsen N, Keski-Oja J, Moses H, Pincus T: Active and latent forms of transforming growth factor β activity in synovial effusions. J Exp Med 169:292, 1989

    Google Scholar 

  37. Brennan FM, Chantry D, Turner M, Foxwell B, Maini R, Feldmann M: Detection of transforming growth factor-beta in rheumatoid arthritis synovial tissue: Lack of effect on spontaneous cytokine production in joint cell cultures. Clin Exp Immunol 81:278–285, 1990

    Google Scholar 

  38. Assoian RK, Fleurdelys BE, Stevenson HC, Miller PJ, Madtes DK, Raines EW, Ross R, Sporn MB: Expression and secretion of type β transforming growth factor by activated human macrophages. Proc Natl Acad Sci 84:6020, 1987

    Google Scholar 

  39. Wahl SM, McCartney-Francis N, Allen JB, Dougherty EB, Dougherty SF: Macrophage production of TGF-β and regulation by TGF-β. Ann NY Acad Sci 593:188–196, 1990

    Google Scholar 

  40. McCartney-Francis N, Mizel D, Wong H, Wahl LM, Wahl SM: TGF-β regulates production of growth factors and TGF-β by human peripheral blood monocytes. Growth Factors 4:27–35, 1990

    Google Scholar 

  41. Grotendorst GR, Smale G, Pencev D: Production of transforming growth factor beta by human peripheral blood monocytes and neutrophils. J Cell Physiol 140:396–402, 1989

    Google Scholar 

  42. Kehrl JH, Wakefield LM, Roberts AB, Jakowlew S, Alvarez-Mon M, Derynck R, Sporn MB, Fauci AS: Production of transforming growth factor-β by human T lymphocytes and its potential role in the regulation of T cell growth. J Exp Med 163:1037, 1986

    Google Scholar 

  43. Lafyatis R, Thompson NL, Remmers EF, Flanders KC, Roche NS, Kim SJ, Case JP, Sporn MB, Roberts AB, Wilder RL: Transforming growth factor-β production by synovial tissues from rheumatoid patients and streptococcal cell wall arthritic rats. J Immunol 143:1142–1148, 1989

    Google Scholar 

  44. Yamamura M, Uyemura K, Deans RJ, Weinberg K, Rea TH, Bloom BR, Modlin RL: Defining protective responses to pathogens: Cytokine profiles in Leprosy lesions. Science 254:277–279, 1991

    Google Scholar 

  45. Wiseman DM, Polverini PJ, Kamp DW, Leibovich SJ: Transforming growth factor-beta (TGF-β) is chemotactic for human monocytes and induces their expression of angiogenic activity. Biochem. Biophys Res Commun 157:793, 1988

    Google Scholar 

  46. Chantry D, Turner M, Abney E, Feldmann M: Modulation of cytokine production by transforming growth factor-β1. J Immunol 142:4295–4300, 1989

    Google Scholar 

  47. Turner M, Chantry D, Feldmann M: Transforming growth factor β induces the production of interleukin 6 by human peripheral blood mononuclear cells. Cytokine 2:211, 1990

    Google Scholar 

  48. Bristol LA, Ruscetti FW, Brody DT, Durum SK: IL-1α induces expression of active transforming growth factor-β in nonproliferating T cells via a post-transcriptional mechanism. J Immunol 145:4108–4114, 1990

    Google Scholar 

  49. Welch G, Wong H, Wahl SM: Selective induction of FcγRIII on human monocytes by transforming growth factor-β. J Immunol 144:344–3448, 1990

    Google Scholar 

  50. Phillips JH, Chang C, Lanier LL: Platelet-induced expression of FCγRIII (CD16) on human monocytes. Eur J Immunol 21:895–899, 1991

    Google Scholar 

  51. Wahl SM, Allen JB, Welch G, Wong H: Transforming growth factor β in synovial fluids modulates FCγRIII (CD16) expression on mononuclear phagocytes. J Immunol 148:485–490, 1992

    Google Scholar 

  52. Allen JB, Wong HL, Guyre P, Simon G, Wahl SM: Circulating FcγRIII positive monocytes in AIDS patients. Induction by transforming growth factor beta. J Clin Invest 87:1773–1779, 1991

    Google Scholar 

  53. Brandes ME, Wakefield LM, Wahl SM: Modulation of monocyte type 1 TGF-β receptors by inflammatory stimuli. J Biol Chem 266:19697–19703, 1991

    Google Scholar 

  54. Lee HM, Rich S: Co-stimulation of T cell proliferation by transforming growth factor-β1. J Immunol 147:1127–1133, 1991

    Google Scholar 

  55. Swain SL, Huston G, Tonkonogy S, Weinberg A: Transforming growth factor-β and IL-4 cause helper T cell precursors to develop into disting effector helper cells that differ in lymphokine secretion pattern and cell surface phenotype. J Immunol 147:2991–3000, 1991

    Google Scholar 

  56. Manthey CL, Allen JB, Ellinsworth LR, Wahl SM: In situ expression of transforming growth factor beta in streptococcal cell wall-induced granulomatous inflammation and hepatic fibrosis. Growth Factors 4:17–26, 1990

    Google Scholar 

  57. Wahl AM, Allen JB, Brandes ME: Cytokine modulation of bacterial cell wall-induced arthritis.In Progress in Inflammation Research and Therapy. Birkhäuser Verlag, Basel pp 29–34, 1991

    Google Scholar 

  58. Wahl SM, Allen JB, Wong H, Dasch J: Reversal of synovial inflammation by antibodies to TGF-β (submitted for publication), 1992

  59. Border WA, Okuda S, Languino LR, Sporn MB, Ruoslahti E: Suppression of experimental glomerulonephritis by antiserum against transforming growth factor beta 1. Nature 346:6282, 1990

    Google Scholar 

  60. Brandes ME, Wahl SM: Acute and chronic downregulation of type I TGF-β receptors by TGF-β (submitted), 1992

  61. Mangan DF, Wahl SM: Differential regulation of monocyte programmed cell death (apoptosis) by chemotactic factors and inflammatory cytokines. J Immunol 147:3408–3412, 1991

    Google Scholar 

  62. Postlethwaite AE, Keski-Oja J, Moses HL, Kang AH: Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor beta. J Exp Med 165:251–256, 1987

    Google Scholar 

  63. Leof EB, Proper JA, Goustin AS, Shipley GD, DiCorleto PE, Moses HC: Induction of c-sis mRNA and platelet-derived growth factor-like activity by transforming growth factor type-β: A proposed model for indirect mitogenesis involving autocrine activity. Proc Natl Acad Sci 83:2453–2457, 1986

    Google Scholar 

  64. Ishikawa O, LeRoy EC, Trojanowska M, Mitogenic effect of transforming growth factor β1 on human fibroblasts involves the induction of platelet-derived growth factor α receptors. J Cell Physiol 145:181–186, 1990

    Google Scholar 

  65. Ignotz RA, Endo T, Massagué J: Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-β J Biol Chem 262:6443–6446, 1987

    Google Scholar 

  66. Yang EY, Moses HL: Transforming growth factor beta 1-induced changes in cell migration, proliferation, and angiogenesis in the chicken chorioallantoic membrane. J Cell Biol 111:731–471, 1990

    Google Scholar 

  67. Overall CM, Wrana JL, Sodek J: Independent regulation of collagenase, 72-kDa progelatinase, and metalloendoproteinase inhibitor expression in human fibroblasts by transforming growth factor-β. J Biol Chem 264:1860–1869, 1989

    Google Scholar 

  68. Edwards DR, Murphy G, Reynolds JJ, Whitman SE, Docherty AJP, Angel P, Heath JK: Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor. EMBO J 6:1899–1904, 1987

    Google Scholar 

  69. Mustoe TA, Pierce GF, Thomason A, Gramates P, Sporn MB, Deuel TF: Transforming growth factor type beta induces accelerated healing of incisional wounds in rats. Science 237:1333–1336, 1987

    Google Scholar 

  70. Smiddy WE, Glaser BM, Green R, Connor TB, Roberts AB, Lucas R, Sporn MB: Transforming growth factor beta—a biologic chorioretinal glue. Arch Opthalmol 107:577–580, 1989

    Google Scholar 

  71. Raghow R, Postlethwaite AE, Keski-Oja J, Moses HL, Kang AH: Transforming growth factor-β increases steady state levels of type I procollagen, and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts. J Clin Invest 79:1285–1288, 1987

    Google Scholar 

  72. Varga J, Rosenbloom J, Jimenez SA: Transforming growth factor β (TGF-β) causes a persistent increase in steady-state amount of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts. Biochem J 247:597–604, 1987

    Google Scholar 

  73. Rossi P, Roberts AB, Roche NS, Karsenty B, Sporn MB, de Crombrugghe B: A nuclear factor 1 binding site mediates the transcriptional activation of a type 1 collagen promoter by transforming growth factor-β. Cell 52:405–414, 1988

    Google Scholar 

  74. Armendariz-Borunda J, Seyer JM, Kang AH, Raghow R: Regulation of TGF-β gene expression in rat liver intoxicated with carbon tetrachloride. FASEB J 4:215–221, 1990

    Google Scholar 

  75. Czaja MJ, Weiner FR, Flanders KC, Giambrone MA, Wind R, Biempica L, Zern MA: In vitro and in vivo association of transforming growth factor-β1 with hepatic fibrosis. J Cell Biol 108:2477–2482, 1989

    Google Scholar 

  76. Khalil N, Bereznay O, Sporn M, Greenberg AH: Macrophage production of transforming growth factor β and fibroblast collagen synthesis in chronic pulmonary inflammation. J Exp Med 170:727–737, 1989

    Google Scholar 

  77. Perkett EA, Lyons RM, Moses HL, Brigham KL, Meyrick B: Transforming growth factor β activity in sheep lung lymph during the development of pulmonary hypertension. J Clin Invest 86:1459–1464, 1990

    Google Scholar 

  78. Kulozik M, Hogg A, Lankat-Buttgereit B, Kreig T: Colocalization of transforming growth factor β2 with α1 (1) procollagen mRNA in tissue sections of patients with systemic sclerosis. J Clin Invest 86:917–922, 1990

    Google Scholar 

  79. Castilla A, Prieto J, Fausto N: Transforming growth factors β1 and α in chronic liver disease. Effects of interferon alfa therapy. New Engl J Med 324:933–940, 1991

    Google Scholar 

  80. Peltonen J, Kahari L, Jaakkola S, Kahari V-M, Varga J, Uitto J, Jimenez SA: Evaluation of transforming growth factorβ and type I procollagen gene expression in fibrotic skin diseases by in situ hybridization. J Invest Dermatol 94:365–371, 1990

    Google Scholar 

  81. Connor TB, Roberts AB, Sporn MB, Danielpour D, Dart LL, Michels RG, de Bustros S, Enger C, Kato H, Lansing M, Hayashi H, Glaser BM: Correlation of fibrosis and transforming growth factor-β type 2 levels in the eye. J Clin Invest 83:1661–1666, 1989

    Google Scholar 

  82. Terui T, Niitsu Y, Mahara K, Fujisaki Y, Urushizaki Y, Mogi, Y, Kohgo Y, Watanabe N, Ogura M, Saito H: The production of transforming growth factor-β in acute mega-karyoblastic leukemia and its possible implication in myelofibrosis. Blood 75:1540–1548, 1990

    Google Scholar 

  83. Gentry LE, Nash BW: The pro domain of pre-protransforming growth factor β1 when independently expressed is a functional binding protein for the mature growth factor. Biochemistry 29:6851–6857, 1990

    Google Scholar 

  84. Danielpour D, Sporn MB. Differential inhibition of transforming growth factor β1 and β2 activity by α2-macroglobulin. J Biol Chem 265:6973–6977, 1990

    Google Scholar 

  85. Wong HL, Welch GR, Brandes ME, Wahl SM: Interleukin-4 (IL-4) antagonizes induction of FcγRIII (CD16) expression by TGF-β on human monocytes. J Immunol 147:1843–1848, 1991

    Google Scholar 

  86. Kahari VM, Qiu-Chen Y, Ming WS, Ramirez F, Uitto J: Tumor necrosis factor-α and interferon-γ suppress the activation of human type I collagen gene expression by transforming growth factor-β1. J Clin Invest 86:1489–1495, 1990

    Google Scholar 

  87. Massagué J, Cheifetz S, Boyd FT, Andres JL: TGF-β receptors and TGF-β binding proteoglycans: Recent progress in identifying their functional properties. Ann NY Acad Sci 593:59–72, 1990

    Google Scholar 

  88. Segarini P: A system of transforming growth factor-β receptors. Am J Resp Cell Mol Biol 4:395–396, 1991

    Google Scholar 

  89. Segarini P, Rosen DM, Seyedin SM: Binding of transforming growth factor-β to cell surface proteins varies with cell type. Mol Endocrinol 3:261–272, 1989

    Google Scholar 

  90. Laiho M, Weis FMB, Massagué J: Concomitant loss of transforming growth factor (TGF)-β receptor types I and II in TGF-β resistant cell mutants implicates both receptor types in signal transduction. J Biol Chem 265:18518–18524, 1990

    Google Scholar 

  91. Kumar A, Rogers T, Maizel A, Sharma S: Loss of transforming growth factor β1 receptors and its effects on the growth of EBV-transformed human B cells. 147:998–1006, 1991

    Google Scholar 

  92. Andres JL, Stanley K, Cheifetz S, Massagué J: Membrane-anchored and soluble forms of betaglycan, a polymorphic proteoglycan that binds transforming growth factor-β. J Cell Biol 109:3137–3145, 1989

    Google Scholar 

  93. Chiefetz S, Ling N, Guillemin R, Massagué J: A surface component on GH3 pituitary cells that recognizes transforming growth factor-β, activin, and inhibin. J Biol Chem 263:17225–17228, 1988

    Google Scholar 

  94. O'Grady P, Kuo MD, Baldassare JJ, Huang SS, Huang JS: Purification of a new type high molecular weight receptor (Type V receptor) of transforming growth factor β (TGF-β) from bovine liver. J Biol Chem 266:8583–8589, 1991

    Google Scholar 

  95. Fanger BO, Wakefield LM, Sporn MB: Structure and properties of the cellular receptor for transforming growth factor type beta. Biochemistry 25:3083–3091, 1986

    Google Scholar 

  96. Libby J, Martinez R, Weber MJ: Tyrosine phosphorylation in cells treated with transforming growth factor-β. J Cell Physiol 129:159–166, 1986

    Google Scholar 

  97. Murthy US, Anzano MA, Stadel JM, Greig R: Coupling of TGF-β-induced mitogenesis to G-protein activatin in AKR-2B cells. Biochem Biophys Res Commun 152:1228–1235, 1988

    Google Scholar 

  98. Ellingsworth L, Nakayama D, Segarini P, Dasch J, Carrillo P, Waegell W: Transforming growth factor-βs are equipotent growth inhibitors of interleukin-1-induced thymocyte proliferation. Cell Immunol 114:41–54, 1988

    Google Scholar 

  99. Wahl SM, Hunt DA, Wong HL, Dougherty S, McCartney-Frances N, Wahl LM, Ellingsworth L, Schmidt JA, Hall G, Roberts AB, Sporn MB: Transforming growth factor beta is a potent immunosuppressive agent which inhibits interleukin-1 dependent lymphocyte proliferation. J Immunol 140:3026–3032, 1988

    Google Scholar 

  100. Wahl SM, Hunt DA, Bansal G, McCartney-Francis N, Ellingsworth L, Allen JB: Bacterial cell wall induced immunosuppression: Role of transforming growth factor beta. J Exp. Med. 168:1403–1417, 1988

    Google Scholar 

  101. Siepl C, Malipiero UV, Fontana A: Transforming growth factor β (TGF-β) resistant helper T lymphocyte clones show a concomitant loss of all three types of TGF-β receptors. J Immunol 146:3063–3067, 1991

    Google Scholar 

  102. Brandes ME, Allen JB, Ogawa Y, Wahl SM: TGF-β1 suppress leukocyte recruitment and synovial inflammation in experimental arthritis. J Clin Invest 87:1108–1113, 1991

    Google Scholar 

  103. Kuruvilla AP, Shah R, Hochwald GM, Liggitt HD, Palladino MA, Thorbecke GJ: Protective effect of transforming growth factor β1 on experimental autoimmune diseases in mice. Proc Natl Acad Sci 88:2918–2921, 1991

    Google Scholar 

  104. Racke MK, Dhib-Jalbut S, Cannella B, Albert PS, Raine CS, McFarlin DE: Prevention and treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-β. J Immunol 146:3012–3017, 1991

    Google Scholar 

  105. Johns LD, Flanders KC, Ranges GE, Sriram S: Successful treatment of experimental allergic encephalomyelitis with transforming growth factor-β1. J Immunol 147:1792–1796, 1991

    Google Scholar 

  106. Wallick SC, Figari IS, Morris RE, Levinson AD, Palladino MA: Immunoregulatory role of transforming growth factor β (TGF-β) in development of killer cells: Comparison of active and latent TGF-β1. J Exp Med 172:1777–1784, 1990

    Google Scholar 

  107. Lefer AM, Tsao P, Aoki N, Palladino MA Jr: Mediation of cardioprotection by transforming growth factor-β. Science 249:61–64, 1990

    Google Scholar 

  108. Su HC, Leite-Morris KA, Braun L, Biron CA: A role for transforming growth factor-β1 in regulating natural killer cell and T lymphocyte proliferative responses during acute infection with lymphocytic choriomeningitis virus. J Immunol 147:2712–2727, 1991

    Google Scholar 

  109. Siepl C, Bodmer S, MacDonald HR, Martin RD, Hofer R, Fontana A: The glioblastoma-derived T cell suppressor factor/transforming growth factor-β2 inhibits T cell growth without affecting the interaction of interleukin 2 with its receptor. Eur J Immunol 18:593–600, 1988

    Google Scholar 

  110. Ruegemer JJ, Ho SN, Augustine JA, Schlager JW, Bell MP, McKean DJ, Abraham RT: Regulatory effects of transforming growth factor-β on IL-2- and IL-4-dependent T cell-cycle progression. J Immunol 144:1767–1776, 1990

    Google Scholar 

  111. Pietenpol JA, Holt JT, Stein RW, Moses HL: Transforming growth factor β1 suppression of c-myc gene transcription: Role in inhibition of keratinocyte proliferation. Proc Natl Acad Sci USA 87:3758–3762, 1990

    Google Scholar 

  112. Laiho M, DeCaprio JA, Ludlow JW, Livingston DM, Massagué J: Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation. Cell 62:175, 1990

    Google Scholar 

  113. Dubois CM, Ruscetti FW, Palaszynski EW, Falk LA, Oppenheim JJ, Keller JR: Transforming growth factor β is a potent inhibitor of interleukin 1 (IL-1) receptor expression: Proposed mechanism of inhibition of IL-1 action. J Exp Med 172:737–744

  114. Harvey AK, Hrubey PS, Chandrasekhar S: Transforming growth factor-β inhibition of interleukin-1 activity involves down-regulation of interleukin-1 receptors on chondrocytes. Exp Cell Res 195:376–385, 1991

    Google Scholar 

  115. Turner M, Chantry D, Katsikis P, Berger A, Brennan GM, Feldman M: Induction of the interleukin 1 receptor antagonist protein by transforming growth factor-β. J Immunol 21:1635–1639, 1991

    Google Scholar 

  116. Wahl SM, Costa G, Corcoran M, Wahl LM, Berger AE: Sequential induction of interleukin 1 and interleukin 1 receptor antagonist (IL-1ra) in human monocytes by transforming growth factor β (submitted), 1992

  117. Dripps DJ, Brandhuber BJ, Thompson RC, Eisenberg SP: Interleukin-1 (IL-1) receptor antagonist binds to the 80-kDa Il-1 receptor but does not initiate Il-1 signal transduction. J Biol Chem 266:10331–10336, 1991

    Google Scholar 

  118. Salgame P, Abrams JS, Clayberger C, Goldstein H, Convit J, Modlin RL, Bloom BR: Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science 254:279–282, 1991

    Google Scholar 

  119. Lotz M, Kekow J, Carson DA: Transforming growth factor-β and cellular immune responses in synovial fluids. J Immunol 144:4189–4194, 1990

    Google Scholar 

  120. Keller JR, Mantel C, Sing GK, Ellingsworth LR, Ruscetti SK, Ruscetti FW: Transforming growth factor β1 regulates early murine hematopoietic progenitors and inhibits the growth of interleukin 3-dependent myeloid leukemia cell lines. J Exp Med 168:737, 1988

    Google Scholar 

  121. Ottman OG, Pelus LM: Differential proliferative effects of transforming growth factor-β on human hematopoietic progenitor cells. J Immunol 140:2661, 1988

    Google Scholar 

  122. Sing GK, Keller JR, Ellingsworth LR, Ruscetti FW: Transforming growth factor β selectively inhibits normal and leukemic human bone marrow cell growth in vitro. Blood 72:1504, 1988

    Google Scholar 

  123. Ishibashi T, Miller SL, Burstein SA: Type β transforming growth factor is a potent inhibitor of murine megakaryocytopoiesisin vitro. Blood 69:1737–1741, 1987

    Google Scholar 

  124. Strassman G, Cole MD, Newman W: Regulation of colony-stimulating factor 1-dependent macrophage precursor proliferation by type β transforming growth factor. J Immunol 140:2645, 1988

    Google Scholar 

  125. Goey H, Keller JR, Back T, Longo DL, Ruscetti FW, Wiltrout RH: Inhibition of early murine hemopoietic progenitor cell proliferation after in vivo locoregional administration of transforming growth factor-β1. J Immunol 143:877–880, 1989

    Google Scholar 

  126. Neta R, Oppenheim JJ, Schreiber RD, Chizzonite R, Ledney GD, MacVittie TJ: Role of cytokines (interleukin 1, tumor necrosis factor, and transforming growth factor β) in natural and lipopolysaccharide-enhanced radioresistance. J Exp Med 173:1177–1182, 1991

    Google Scholar 

  127. Hatzfeld J, Li ML, Brown EL, Sookdeo H, Levesque JP, O'Toole T, Gurney C, Clark SC, Hatzfeld A: 1991. Release of early human hematopoietic progenitors from quiescence by antisense transforming growth factor β1 or Rb oligonucleotides. J Exp Med 174:925–929, 1991

    Google Scholar 

  128. Glick AB, Flanders KC, Danielpour D, Yuspa SH, Sporn MB: Retinoic acid induces transforming growth factor β2 in cultured keratinocytes and mouse epidermis. Cell Regulat 1:87–97, 1989

    Google Scholar 

  129. Gresham HD, Ray CJ, O'Sullivan FX: Defective neutrophil function in the autoimmune mouse strain MRL/lpr. J Immunol 146:3911–3921, 1991

    Google Scholar 

  130. Taylor AW, Ku NO, Mortensen RF: Regulation of cytokine-induced human C-reactive protein production by transforming growth factor-β1. J Immunol 145:2507–2513, 1990

    Google Scholar 

  131. Czarniecki CW, Chiu HH, Wong GHW, McCabe SM, Palladino MA: Transforming growth factor-β1 modulates the expression of class II histocompatibility antigens on human cells. J Immunol 140:4217, 1988

    Google Scholar 

  132. Ohta M, Greenberger JS, Anklesaria P, Bassols A, Massagué J: Two forms of transforming growth factor-β distinguished by multipotential hematopoietic progenitor cells. Nature (Lond) 329:539–541, 1987

    Google Scholar 

  133. Ranges GE, Figari IS, Espevik T, Palladino MA: Inhibition of cytotoxic T cell development by transforming growth factor β and reversal by recombinant tumor necrosis factor α. J Exp Med 166:991, 1987

    Google Scholar 

  134. Musso T, Epionza-Delgado I, Pulkki K, Gusella GL, Longo DL, Varesio L: Transforming growth factor β downregulates interleukin-1 (IL-1) induced IL-6 production by human monocytes. Blood 76:2466–2469, 1990

    Google Scholar 

  135. Espevik T, Figari IS, Shalaby MR, Lackides GA, Lewis GD, Shepard HM, Palladino Jr, MA: Inhibition of cytokine production by cyclosporin A and transforming growth factor β. J Exp Med 166:571–576, 1987

    Google Scholar 

  136. Tsunawaki S, Sporn M, Ding A, Nathan C: Deactivation of macrophages by transforming growth factor-β. Nature 334:260, 1988

    Google Scholar 

  137. Ding A, Nathan CF, Graycar J, Derynck R, Stuehr DL, Srimal S: Macrophage deactivating factor and transforming growth factor-β1,-β2, and -β3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-γ1. J Immunol 145:940–944, 1990

    Google Scholar 

  138. Rook AH, Kehrl JH, Wakefield LM, Roberts AB, Sporn MB, Burlington DB, Lane HC, Fauci AS: Effects of transforming growth factor β on the functions of natural killer cells: Depressed cytolytic activity and blunting of interferon responsiveness. J Immunol 136:3916, 1986

    Google Scholar 

  139. Mulé JJ, Schwarz SL, Roberts AB, Sporn MB, Rosenberg SA: Transforming growth factor-beta inhibits the in vitro generation of lymphokine-activated killer cells and cytotoxic T cells. Cancer Immunol Immunother 26:95, 1988

    Google Scholar 

  140. Fontana A, Frei K, Bodmer S, Hofer E, Schreider MH, Pallino Jr, MA, Zindernagel, RM: Transforming growth factor-β inhibits the generation of cytotoxic T cells in virus-infected mice. J Immunol 143:3230–3234, 1989

    Google Scholar 

  141. Espevik T, Figari IS, Ranges GE, Palladino MA: Transforming growth factor-β1 (TGF-β1) and recombinant human tumor necrosis factor-α reciprocally regulate the generation of lymphokine-activated killer cell activity: Comparison between natural porcine platelet-derived TGF-β1 and TGF-β2, and recombinant human TGF-β1. J Immunol 140:2312, 1988

    Google Scholar 

  142. Ortaldo JR, Mason AT, O'Shea JJ, Smyth MJ, Falk LA, Kennedy, ICS, Longo DL, Ruscetti FW: Mechanistic studies of transforming growth factor β inhibition of IL-2 dependent activation of CD3-large granular lymphocyte functions. J Immunol 146:3791–3798, 1991

    Google Scholar 

  143. Koo GC, Manyak CL, Dasch J, Ellingsworth L, Shultz LD: Suppressive effects of monocytic cells and transforming growth factor-β on natural killer cell differentiation in autoimmune viable motheaten mutant mice. J Immunol 147:1194–1200, 1991

    Google Scholar 

  144. Smyth MJ, Strobl SL, Young HA, Ortaldo JR, Ochoa AC: Regulation of lymphokine-activated killer activity and poreforming protein gene expression in human peripheral blood CD8+ T lymphocytes. J Immunol 146:3289–3297, 1991

    Google Scholar 

  145. Kehrl JH, Taylor AS, Delsing GA, Roberts AB, Sporn MB, Fauci AS: Further studies of the role of transforming growth factor-β in human B cell function. J Immunol 143:1868–1874, 1989

    Google Scholar 

  146. Kehrl JH, Thevenin C, Rieckmann P, Fauci A: Transforming growth factor-β suppresses human B lymphocyte Ig production by inhibiting synthesis and the switch from the membrane form to the secreted form of Ig mRNA. J Immunol 146:4016–4023, 1991

    Google Scholar 

  147. Sonoda E, Matsumoto R, Hitoshi Y, Ishii T, Sugimoto M, Araki S, Tominaga A, Yamaguchi N, Takatsu K: Transforming growth factor β induces IgA production and acts additively with interleukin 5 for IgA production. J Exp Med 170:1415, 1989

    Google Scholar 

  148. Kim PH, Kagnoff MF: Transforming growth factor β1 increases IgA isotype switching at the clonal level. J Immunol 145:3773–3778, 1990

    Google Scholar 

  149. Coffman RL, Lebman DA, Shrader B: Transforming growth factor β specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes. J Exp Med 170:1039, 1989

    Google Scholar 

  150. Tanaka M, Lee K, Yodoi J, Saito H, Iwai Y, Kim KM, Morita M, Mayumi M, Mikawa H: Regulation of Fce receptor 2 (CD23) expression on a human eosinophilic cell line EoL3 and a human monocytic cell line U937 by transforming growth factor β. Cell Immunol 122:96, 1989

    Google Scholar 

  151. Kekow J, Wachsman W, McCutchan JA, Cronin M, Carson DA, Lotz M: Transforming growth factor β and noncytopathic mechanisms of immunodeficiency in human immunodeficiency virus infection. Proc Natl Acad Sci USA 87:8321, 1990

    Google Scholar 

  152. Lotz M, Kekow J, Cronin MT, McCutchan JA, Clark-Lewis I, Carson DA, Wachsman W: Induction of transforming growth factor-β (TGF-β) by HIV-1 tat: A noncytopathic pathway of immunodeficiency in HIV infection. FASEB J 4:A2014, 1990

    Google Scholar 

  153. Wahl SM, Allen JB, McCartney-Francis N, Morganti-Kossman MC, Kossman T, Ellingsworth L, Mergenhagen SE, Orenstein JM: Transforming growth factor beta. A potential macrophage and astrocyte-derived mediator of CNS dysfunction in AIDS. J Exp Med 173:891–899, 1991

    Google Scholar 

  154. Nakajima K, Martinez-Maza O, Hirano T, Breen EC, Nishanian PG, Salazar-Gonzalez JF, Fahey JL, Kishimoto T: Induction of IL-6 (B cell stimulatory facto-2/IFN-b2) production by HIV. J Immunol 142:531–536, 1989

    Google Scholar 

  155. Zhou D, Munster A, Winchurch RA: Pathologic concentrations of interleukin 6 inhibit T cell responses via induction of activation of TGF-β. FASEB J 5:2582–2585, 1991

    Google Scholar 

  156. Poli G, Kinter AL, Justement JS, Bressler P, Kehrl JH, Fauci AS: Transforming growth factor β suppresses human immunodeficiency virus expression and replication in infected cells of the monocyte/macrophage lineage. J Exp Med 173:589, 1991

    Google Scholar 

  157. Lazdins JK, Klimkait T, Woods-Cook K, Walker M, Alteri E, Cox D, Cerletti N, Shipman R, Bilbe G, McMaster G: In vitro effect of transforming growth factor-β on progression of HIV-1 infection in primary mononuclear phagocytes. J Immunol 147:1201–1207, 1991

    Google Scholar 

  158. Peterson PK, Gekker G, Chao CC, Schut R, Molitor TW, Balfour HH Jr: Cocaine potentiates HIV-1 replication in human peripheral blood mononuclear cell cocultures. J Immunol 146:81–84, 1991

    Google Scholar 

  159. Nelson BJ, Ralph P, Green SJ, Nacy CA: Differential susceptibility of activated macrophage cytotoxic effector reactions to the suppressive effects of transforming growth factor-β1. J Immunol 46:1849–1857, 1991

    Google Scholar 

  160. Silva JS, Twardzik DR, Reed S: Regulation of Trypanosoma cruzi infections in vitro and in vivo by transforming growth factor β (TGF-β). J Exp Med 174:539–545, 1991

    Google Scholar 

  161. Su HC, Leite-Morris KA, Braun L, Biron CA: A role for transforming growth factor-β1 in regulating natural killer cell and T lymphocyte proliferative responses during acute infection with lymphocytic choriomeningitis virus. J Immunol 147:2717–2727, 1991

    Google Scholar 

  162. Smith PD, Wahl SM: Cytokines.In Natural Immunity, DS. Nelson (ed). New York, Academic Press, 1989, pp 241–283

    Google Scholar 

  163. Chao CC, Janoff EN, Hu S, Thomas K, Gallagher M, Tsang M, Peterson PP: Altered cytokine release in peripheral blood mononuclear cell cultures from patients with chronic fatigue syndrome. Cytokine 3:292–298, 1991

    Google Scholar 

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Wahl, S.M. Transforming growth factor beta (TGF-β) in inflammation: A cause and a cure. J Clin Immunol 12, 61–74 (1992). https://doi.org/10.1007/BF00918135

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