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Myofibroblast-like cells in human anterior capsular cataract

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Summary

In six cases of anterior capsular cataract, cells present in the subcapsular zone were investigated. In addition to orga nelles previously described, the cells were found to contain 7 nm and 15 nm filaments, suggestive of actin and myosin. The cells varied in shape from elongated or flat to rounded. Maculae adhaerentes, gap junctions and basement membranes were present. It is concluded that these cells closely resemble myofibroblasts, by virtue of their cytology and behaviour. The significance of this observation, concerning hypotheses on the genesis of anterior capsular cataract is discussed.

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References

  • Bailey AJ, Bazin S, Sims TJ, LeLous M, Nicoletis C, Delaunay A (1975) Characterizationof the collagen of human hypertrophic and normal scars. Biochim Biophys Acta 405:412–421

    Google Scholar 

  • Bailey AJ, Sims TJ, LeLous M, Bazin S (1975b) Collagen polymorphism in experimental granulation tissue. Biochem Biophys Res Com 66:1160–1165

    Google Scholar 

  • Balázs M (1981) Amyloidosis of the stomach. Report of a case with ultrastructure. Virchows Arch [Pathol Anat] 391:227–240

    Google Scholar 

  • Böck P, Breitenecker G, Lunglmayr G (1972) Kontraktile Fibroblasten (Myofibroblasten) in der lamina propria der Hodenkanälchen vom Menschen. Z Zellforsch 133:519–527

    Google Scholar 

  • Bressler RS (1973) Myoid cells in the capsule of the adrenal gland and in monolayers derived from cultured adrenal capsules. Anat Rec 177:525–532

    Google Scholar 

  • Buntrock P (1980) Ultrastrukturelle Charakterisierung von Fibroblasten, Myofibroblasten und Fibroklasten im Wundheilungsprozeß. Zbl Allg Path Path Anat 124:48–59

    Google Scholar 

  • Font RL, Brownstein S (1974) A light and electron microscopic study of anterior subcapsular cataracts. Am J Ophthal 78:972–984

    Google Scholar 

  • Gabbiani G (1979) The role of contractile proteins in would healing and fibrocontractive diseases. Meth Achiev Exp Pathol 9:187–206

    Google Scholar 

  • Gabbiani G (1981) The myofibroblast: A key cell for wound healing and fibrocontractive diseases. In: Deyl Z, Adam M (eds) Connective tissue research: Chemistry, Biology and Physiology. Alan R. Liss Inc, New York, p 183

    Google Scholar 

  • Gabbiani G, Hirschel BJ, Ryan GB, Statkov PR, Majno G (1972) Granulation tissue as a contractile organ. A study of structure and function. J Exp Med 135:719–734

    Google Scholar 

  • Gabbiani G, Majno G (1972) Dupuytren's contracture: fibroblast contraction? An ultrastructural study. Am J Pathol 66:131–138

    Google Scholar 

  • Gabbiani G, Ryan GB (1974) Development of a contractile apparatus in epithelial cells during epidermal and liver regeneration. J Submicr Cytol 6:143–157

    Google Scholar 

  • Gabbiani G, Ryan GB, Majno G (1971) Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction. Experientia 27:549–550

    Google Scholar 

  • Ghosh M, McCulloch C (1975) Anterior subcapsular cataract. An electron microscopic study. Canad J Ophthal 10:502–510

    Google Scholar 

  • Gorgas K, Böck P (1974) Myofibroblasts in the rat testicular capsule. Cell Tiss Res 154:533–541

    Google Scholar 

  • Güldner FH, Wolff JR, Graf Keyserlingk D (1972) Fibroblasts as a part of the contractile system in duodenal villi of rat. Z Zellforsch 135:349–360

    Google Scholar 

  • Henkind P, Prose P (1967) Anterior polar cataract. Electron microscopic evidence of collagen. Am J Opthal 63:768–771

    Google Scholar 

  • Ireland M, Maisel H (1982) Actin filaments of lens fiber cells. Ophthal Res 14:428–435

    Google Scholar 

  • Iwig M, Glaesser D, Bethge M (1981) Cell-shape mediated growth control of lens epithelial cells grown in culture. Exp Cell Res 131:47–55

    Google Scholar 

  • Kapanci Y, Assimacopoulos A, Irlé C, Zwahlen A, Gabbiani G (1974) “Contractile interstitial cells” in pulmonary alveolar septae; a possible regulator of ventilation/perfusion ratio? J Cell Biol 60:375–392

    Google Scholar 

  • Krawczyk WS (1971) A pattern of epidermal cell migration during wound healing. J Cell Biol 49:247–263

    Google Scholar 

  • Lamb HD (1937) Anterior capsular cataract. An example of true mataplasia. Arch Ophthal 17:877–881

    Google Scholar 

  • Nemetschek Th, Meinel A, Nemetschek-Gansler H, Reill P, Riedl H (1976) Zur Ätiologie der Kontraktur beim Morbus Dupuytren. Virchows Arch [pathol Anat] 372:57–74

    Google Scholar 

  • Parker F, Odland GF (1966) A light microscopic, histochemical and electron microscopic study of experimental atherosclerosis in rabbit coronary artery and a comparison with rabbit aorta atherosclerosis. Am J Pathol 48:451–481

    Google Scholar 

  • Pau H, Caesar R (1967) Elektronenmikroskopische Studie zur Herkunft der Kollagenfasern im Kapselstar. Graefe's Arch Exp Clin Ophthal 171:327–336

    Google Scholar 

  • Pott G, Staubesand J (1977) Lysosomen and lysosomale Enzyme in der Wand fehlbelasteter Arterien der Ratte. Res Exp Med 170:271–281

    Google Scholar 

  • Riede UN, Staubesand J (1977) A unifying concept for the role of matrix vesicles and lysosomes in the formal pathogenesis of diseases of connective tissues and blood vessels. Beitr Pathol 160:3–37

    Google Scholar 

  • Schürch W, Seemayer TA, Legace R (1981) Stromal myofibroblasts in primary invasive and metastatic carcinomas. A combined immunological, light and electron microscopic study. Virchows Arch [Pathol Anat] 391:125–139

    Google Scholar 

  • Staubesand J (1978) Entstehung und Bedeutung der sog. Matrix Vesikel bei Umbauvorgängen in der Gefäßwand. Verh Anat Ges 72:493–496

    Google Scholar 

  • Staubesand J (1980) Hämodynamische Fehlbelastung - Risikofaktor für die Gefäßwand. In: Klüken N, Brändle I, Stemmer R (eds) Ergebnisse der Angiologie, vol. 20. Schattauer, Stuttgart - New York, p 7

    Google Scholar 

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Novotny, G.E.K., Pau, H. Myofibroblast-like cells in human anterior capsular cataract. Vichows Archiv A Pathol Anat 404, 393–401 (1984). https://doi.org/10.1007/BF00695223

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