Summary
The three-dimensional microvascular architecture of human glioma was investigated. The results of the study, the first of its kind, suggested that the process of vascularization in glioma is based on two patterns. In a large proportion of the glioma, one pattern is similar to the vascularization observed in normal developing fetal and newborn rat brain, while in a small proportion of the glioma, another pattern including complicated vascular protrusion and spiral running, is seen.
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References
Anderson BG, Anderson WD (1978) Scanning electron microscopy of microcorrosion casts. Intracranial and abdominal microvasculature in domestic animals. Am J Anat 153:523–536
Bär T, Wolff JR (1972) The formation of capillary basement membranes during internal vascularization of the rat's cerebral cortex. Z. Zellforsch 133:231–248
Duvernoy HM, Delon S, Vannson JL (1981) Cortical blood vessels of the human brain. Brain Res Bull 7:519–579
Grothius DR, Fischer JM, Vick NA, Bigner DD (1980) Experimental glioma. An autoradiographic study of the endothelial component. Neurology 30:297–301
Hirano A, Zimmerman HM (1972) Fenestrated blood vessels in a metastatic renal carcinoma in the brain. Lab Invest 26:465–468
Hirano A, Matsui T (1975) Vascular structures in brain tumors. Hum Pathol 6:611–621
Ito M, Lammertsma AA, Wise RJS, Bernardi S, Frackowiak RSJ, Heather JD, McKenzie CG, Thomas DGT, Jones T (1982) Measurement of regional cerebral blood flow and oxygen utilization in patient with cerebral tumours using15O and positron emission tomography: analytical technique and preliminary results. Neuroradiology 23:63–74
Long DM (1979) Capillary ultrastructure in human metastatic brain tumors. J Neurosurg 51:53–58
Motti EDF, Imhof HG, Yasargil GM (1986) The terminal vascular bed in the superficial cortex of the rat. An SEM study of corrosion casts. J Neurosurg 65:834–846
Murakami T, Miyoshi M, Fujita T (1971) Glomerular vessels of the rat kidney with special reference to double efferent arterioles. A scanning electron microscope study of corrosion casts. Arch Histol Jap 33:179–198
Orita T, Nishizaki T, Kamiryo T, Harada K, Aoki H (1988) Cerebral microvascular architecture following experimental cold injury. J Neurosurg 68:608–612
Russell DS, Rubinstein LJ (1977) Pathology of tumours of the nervous system, 4th edn. Arnold, London, pp 235–236
Takeda N (1980) Dynamics of contrast medium in experimental brain tumors. An autoradiographical study. Neurol Med Chir (Tokyo) 20:853–863
Yoshida Y (1983) Stereoscopic vascular morphology in experimental gliomas and its relationship with normal vascularization in the developmental stage. Brain Nerve (Tokyo) 35:619–627
Yoshida Y, Ikuta F, Watabe K, Nagata T (1985) Developmental microvascular architecture of the rat cerebellar cortex. Anat Embryol 171:129–138
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Orita, T., Nishizaki, T., Kamiryo, T. et al. The microvascular architecture of human malignant glioma. Acta Neuropathol 76, 270–274 (1988). https://doi.org/10.1007/BF00687774
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DOI: https://doi.org/10.1007/BF00687774