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Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse

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Summary

A systematic observational method is described for comprehensively assessing and quantifying the behavioral and physiologic state of the mouse and its response to drugs. With this method, the pattern profile of various classes of pharmacologic agents and their members can be identified and differentiated, and the relative specificity of their actions defined. The method is applicable to a wide range of investigative goals. Inter- and intra-observer reliability studies have shown it to meet the pragmatic requirements for research.

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Authors and Affiliations

  1. Department of Psychiatry, University of Oregon Medical School, Portland, Oregon

    Samuel Irwin

  2. Oregon Regional Primate Research Center Beaverton, Oregon

    Samuel Irwin

Authors
  1. Samuel Irwin
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Additional information

The procedure was developed initially at Schering Corp., Bloomfield, N. J. Its further development and revision was supported by grant No. MH 10990 of the National Institutes of Mental Health.

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Irwin, S. Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse. Psychopharmacologia 13, 222–257 (1968). https://doi.org/10.1007/BF00401402

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  • DOI: https://doi.org/10.1007/BF00401402

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