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The insulin secretory granule

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  • Published: May 1989
  • Volume 32, pages 271–281, (1989)
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The insulin secretory granule
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  • J. C. Hutton1 

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Summary

The insulin secretory granule of the pancreatic B cell is a complex intracellular organelle comprised of a many proteins with different catalytic activities and messenger functions. With the advent of tumour models of the B cells and the application of immunological and molecular cloning techniques considerable progress has been made in recent years towards the elucidation of the structure and function of these granule proteins. A number of examples are selected here for review. Particular emphasis given to how the activities of quite different granule proteins are interdependent and how this contributes to the co-ordination and integration of the organelle's biological functions.

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Author information

Authors and Affiliations

  1. Department of Clinical Biochemistry, Addenbrooke's Hospital, Cambridge, UK

    J. C. Hutton

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  1. J. C. Hutton
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Additional information

This paper is based upon the text of the 24th Minkowski lecture of the European Association for the Study of Diabetes, delivered at its annual meeting in Paris, September 1988

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Hutton, J.C. The insulin secretory granule. Diabetologia 32, 271–281 (1989). https://doi.org/10.1007/BF00265542

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  • Issue Date: May 1989

  • DOI: https://doi.org/10.1007/BF00265542

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Key words

  • Insulin
  • granule
  • vesicle
  • proton pump
  • prohormone conversion
  • autocrine
  • chromogranin A
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