Skip to main content

Advertisement

Springer Nature Link
Log in

Macrophage-mediated destruction of malignant tumor cells and new strategies for the therapy of metastatic disease

  • Published:
Springer Seminars in Immunopathology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (Canada)

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Berendt M J, North R J (1980) T cell-mediated suppression of antitumor immunity. J Exp Med 151: 69

    Google Scholar 

  2. Chirigos M A, Mitchell M, Mastrangelo M J, Krim M (eds) (1981) Modulation of cellular immunity in cancer by immune modifiers. Raven Press, New York

    Google Scholar 

  3. Den Otter E, Dullens Hub F J, Van Lovern H, Pels E (1977) Antitumor effects of macrophages injected into animals: A review. In: James K, McBride B, Stuart A (eds) The macrophage and cancer. Econoprint, Edinburgh, p 119

    Google Scholar 

  4. Eccles S A (1978) Macrophages and cancer. In: Castro J E (ed) Immunological aspects of cancer. University Park Press, Baltimore, p 123

    Google Scholar 

  5. Evans R, Alexander P (1972) Role of macrophages in tumor immunity. I. Cooperation between macrophages and lymphoid cells in syngeneic tumor immunity. Immunology 23: 615

    Google Scholar 

  6. Evans R, Lawler E M (1980) Macrophage content and immunogenicity of C57BL/6J and BALB/cByJ methylcholanthrene-induced sarcomas. Int J Cancer 26: 831

    Google Scholar 

  7. Fidler I J (1974) Inhibition of pulmonary metastasis by intravenous injection of specifically activated macrophages. Cancer Res 34: 1074

    Google Scholar 

  8. Fidler I J (1980) Therapy of spontaneous metastases by intravenous injection of liposomes containing lymphokines. Science 208: 1469

    Google Scholar 

  9. Fidler I J (to be published) Eradication of metastases by tumoricidal macrophages: therapeutic implications. In: Liotta L, Hart I R (eds) Biology of metastasis. Nijhoff, Amsterdam

  10. Fidler I J (1981) The in situ induction of tumoricidal activity in alveolar macrophages by liposomes containing muramyl dipeptide is a thymus-independent process. J Immunol 127: 1719

    Google Scholar 

  11. Fidler I J, Cifone M A (1979) Properties of metastatic and nonmetastatic cloned subpopulations of an ultraviolet light-induced murine fibrosarcoma of recent origin. Am J Pathol 97: 633

    Google Scholar 

  12. Fidler I J, Kripke M L (1980) Biological variability within murine neoplasms. Antibiot Chemother 28: 123

    Google Scholar 

  13. Fidler I J, Poste G (1981) Treatment of spontaneous murine metastases by the systemic administration of liposomes containing macrophage-activating agents. In: Burchenal J H, Oettgen H F (eds) Cancer: Achievements, challenges and prospects for the 1980's, Vol 2. Grune and Stratton, New York, p 77

    Google Scholar 

  14. Fidler I J, Poste G (to be published) The heterogeneity of metastatic properties in malignant tumor cells and regulation of the metastatic phenotype. In: Owens A (ed) Tumor cell heterogeneity. Academic Press, New York

  15. Fidler I J, Poste G (1981) Macrophage destruction of micrometastases. In: Herscowitz H B, Holden H T, Bellanti J A, Ghaffar A (eds) Manual of macrophage methodology. Marcel Dekker, New York, p 509

    Google Scholar 

  16. Fidler I J, Poste G (1981) Activation of tumoricidal properties in murine macrophages by intravenous injection of muramyl dipeptide encapsulated within liposomes as a treatment for spontaneous metastasis. In: Murphy G P (ed) The prostatic cell: Structure and function. A. R. Liss, New York, p 259

    Google Scholar 

  17. Fidler I J, Raz A (1981) The induction of tumoricidal capacities in mouse and rat macrophages by lymphokines. In: Pick E (ed) Lymphokines, Vol 3. Academic Press, New York, p 345

    Google Scholar 

  18. Fidler I J, Barnes Z, Fogler W E, Kirsh R, Bugelski P, Poste G (1982) Involvement of macrophages in the eradication of established metastases produced by intravenous injection of liposomes containing macrophage activators. Cancer Res 42: 496

    Google Scholar 

  19. Fidler I J, Darnell J H, Budmen M B (1976) Tumoricidal properties of mouse macrophages activated with mediators from rat lymphocytes stimulated with concanavalin A. Cancer Res 36: 3608

    Google Scholar 

  20. Fidler I J, Fogler W E, Connor J (1979) The rationale for the treatment of established experimental micrometastases with the injection of tumoricidal macrophages. In: Terry W D, Yamamura Y (eds) Immunobiology and immunotherapy of cancer. Elsevier, New York, p 361

    Google Scholar 

  21. Fidler I J, Hart I R, Raz A, Fogler W E, Kirsh R, Poste G (1980) Activation of tumoricidal properties in macrophages by liposome-encapsulated lymphokines: in vivo studies. In: Tom B H, Six H (eds) Liposomes and immunobiology. Elsevier, New York, p 109

    Google Scholar 

  22. Fidler I J, Raz A, Fogler W E, Kirsh R, Bugelski P, Poste G (1980) Design of liposomes to improve delivery of macrophage-augmenting agents to alveolar macrophages. Cancer Res 40: 4460

    Google Scholar 

  23. Fidler I J, Raz A, Fogler W E, Hoyer L C, Poste G (1981) The role of plasma membrane receptors and the kinetics of macrophage activation by lymphokines encapsulated in liposomes. Cancer Res 41: 495

    Google Scholar 

  24. Fidler I J, Roblin R O, Poste G (1978) In vitro tumoricidal activity of macrophages against virustransformed lines with temperature-dependent transformed phenotypic characteristics. Cell Immunol 38: 131

    Google Scholar 

  25. Fidler I J, Sone S, Fogler W E, Barnes Z (1981) Eradication of spontaneous metastases and activation of alveolar macrophages by intravenous injection of liposomes containing muramyl dipeptide. Proc Natl Acad Sci USA 78: 1680

    Google Scholar 

  26. Fogler W E, Raz A, Fidler I J (1980) In situ activation of murine macrophages by liposomes containing lymphokines. Cell Immunol 53: 214

    Google Scholar 

  27. Gregoriadis G, Allison A C (eds) (1980) Liposomes in biological systems. Wiley Interscience, New York

    Google Scholar 

  28. Hanna N, Fidler I J (1980) Role of natural killer cells in the destruction of circulating tumor emboli. J Natl Cancer Inst 65: 801

    Google Scholar 

  29. Hart I R, Fidler I J (1981) The implications of tumor heterogeneity for studies on the biology and therapy of cancer metastasis. Biochem Biophys Acta 651: 37

    Google Scholar 

  30. Hart I R, Fogler W E, Poste G, Fidler I J (1981) Toxicity studies of liposome-encapsulated immunomodulators administered intravenously to dogs and mice. Cancer Immunol Immunother 10: 157

    Google Scholar 

  31. Kerbel R S (1979) Implications of immunological heterogeneity of tumors. Nature 280: 358

    Google Scholar 

  32. Lederer E (1980) Synthetic immunostimulants derived from the bacterial cell wall. J Med Chem 23: 819

    Google Scholar 

  33. Liotta L A, Gattozzi G, Kleinerman J, Saidel G (1977) Reduction of tumor cell entry into vessels by BCG-activated macrophages. Br J Cancer 36: 369

    Google Scholar 

  34. Mantovani A (1978) Effects on in vitro tumor growth of murine macrophages isolated from sarcoma lines differing in immunogenicity and metastasizing capacity. Int J Cancer 22: 741

    Google Scholar 

  35. Mantovani A, Giavazzi R, Polentarutti N, Spreafico F, Gavattini S (1980) Divergent effects of macrophage toxins on growth of primary tumors and lung metastases in mice. Int J Cancer 25: 617

    Google Scholar 

  36. Nicolau C, Paraf A (eds) (1981) Liposomes, drugs and immunocompetent cell functions. Academic Press, London

    Google Scholar 

  37. Papermaster B W, Holtermann O A, Rosner D, Klein E, Dao T, Djerassi I (1974) Regressions produced in breast cancer lesions by a lymphokine fraction from a human lymphoid cell line. Res Commun Chem Pathol Pharmacol 8: 413

    Google Scholar 

  38. Parant M (1979) Biological properties of a new synthetic adjuvant, muramyl dipeptide (MDP). Semin Immunopathol 2: 101

    Google Scholar 

  39. Pick E (ed) (1981) Lymphokines, Vol 3. Academic Press, New York

    Google Scholar 

  40. Poste G (1979) The tumoricidal properties of inflammatory tissue macrophages and multinucleate giant cells. Am J Pathol 96: 595

    Google Scholar 

  41. Poste G, Fidler I J (1980) The pathogenesis of cancer metastasis. Nature 283: 139

    Google Scholar 

  42. Poste G, Fidler I J (1981) Stimulation of macrophage-mediated destruction of lung metastases by administration of immunomodulators encapsulated in liposomes. In: Nicolau C, Paraf A (eds) Liposomes, drugs and immunocompetent cell functions. Academic Press, London, p 147

    Google Scholar 

  43. Poste G, Kirsh R (1979) Rapid decay of tumoricidal activity and loss of responsiveness to lymphokines in inflammatory macrophages. Cancer Res 39: 2582

    Google Scholar 

  44. Poste G, Bucana C, Raz A, Bugelski P, Kirsh R, Fidler I J (1982) Analysis of the fate of systemically administered liposomes and implications for their use in drug delivery. Cancer Res 42: 1412

    Google Scholar 

  45. Poste G, Kirsh R, Fidler I J (1979) Cell surface receptors for lymphokines. Cell Immunol 44: 71

    Google Scholar 

  46. Poste G, Kirsh R, Fogler W E, Fidler I J (1979) Activation of tumoricidal properties in mouse macrophages by lymphokines encapsulated in liposomes. Cancer Res 39: 881

    Google Scholar 

  47. Poste G, Kirsh R, Raz A, Sone S, Bucana C, Fogler W E, Fidler I J (1980) Activation of tumoricidal properties in macrophages by liposome-encapsulated lymphokines: in vitro studies. In: Tom B H, Six S (eds) Liposomes and immunobiology. Elsevier, New York, p 93

    Google Scholar 

  48. Raz A, Bucana C, Fogler W E, Poste G, Fidler I J (1981) Biochemical, morphological and ultrastructural studies on the uptake of liposomes by murine macrophages. Cancer Res 41: 487

    Google Scholar 

  49. Raz A, Fogler W E, Fidler I J (1979) The effects of experimental conditions on the expression of in vitro mediated tumor cytotoxicity mediated by murine macrophages. Cancer Immunol Immunother 7: 157

    Google Scholar 

  50. Rhodes J (1980) Resistance of tumor cells to macrophages. Cancer Immunol Immunother 7: 211

    Google Scholar 

  51. Russell S W, Gillespie G Y, Pace J L (1980) Evidence for mononuclear phagocytes in solid neoplasms and appraisal of their nonspecific cytotoxic capabilities. Contemp Top Immunobiol 10: 143

    Google Scholar 

  52. Sadler T E, Jones P D E, Castro J E (1977) The effects of altered phagocytic activity on growth of primary and metastatic tumours. In: James K, McBridge B, Stuart A (eds) The macrophage and cancer. Econoprint, Edinburgh, p 155

    Google Scholar 

  53. Salvin S B, Youngner J S, Nishio J, Neta R (1975) Tumor suppression by a lymphokine released into the circulation of mice with delayed hypersensitivity. J Natl Cancer Inst 55: 1233

    Google Scholar 

  54. Schabel F M Jr, Griswold D R Jr, Corbett T H, Lloyd H H (1977) Quantitative evaluation of anticancer agent activity in experimental animals. Pharmacol Ther 1: 411

    Google Scholar 

  55. Sone S, Fidler I J (1981) In vitro activation of tumoricidal properties in rat alveolar macrophages by synthetic muramyl dipeptide encapsulated in liposomes. Cell Immunol 57: 42

    Google Scholar 

  56. Sone S, Fidler I J (1981) Activation of rat alveolar macrophages to the tumoricidal state in the presence of progressively growing pulmonary metastases. Cancer Res 41: 2401

    Google Scholar 

  57. Sone S, Poste G, Fidler I J (1980) Rat alveolar macrophages are susceptible to free and liposome-encapsulated lymphokines. J Immunol 124: 2197

    Google Scholar 

  58. Talmadge J E, Key M, Fidler I J (1981) Macrophage content of metastatic and nonmetastatic rodent neoplasms. J Immunol 126: 2245

    Google Scholar 

  59. Trope C (1982) Different susceptibilities of tumor cell subpopulations to cytotoxic agents. In: Fidler I J, White R J (eds) Design of models for testing cancer chemotherapeutic agents. Van Nostrand, New York, p 64

    Google Scholar 

  60. Witz I P, Hanna M G Jr (eds) (1980) In situ expression of tumor immunity. Contemp Top Immunobiol 10: 1

Download references

Author information

Authors and Affiliations

  1. Cancer Metastasis and Treatment Laboratory, NCI-Frederick Cancer Research Facility, 21701, Frederick, Maryland, USA

    Isaiah J. Fidler

  2. Smith Kline and French Laboratories, 1500 Spring Garden Street, P. O. Box 7929, 19101, Philadelphia, Pennsylvania, USA

    George Poste

Authors
  1. Isaiah J. Fidler
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. George Poste
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Research sponsored by the National Cancer Institute, DHHS, under Contract No. NO1-CO-75380 with Litton Bionetics, Inc. The contents of this publication do not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fidler, I.J., Poste, G. Macrophage-mediated destruction of malignant tumor cells and new strategies for the therapy of metastatic disease. Springer Semin Immunopathol 5, 161–174 (1982). https://doi.org/10.1007/BF00199794

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00199794

Keywords

Search

Navigation