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Cullin 4-DCAF Proteins in Tumorigenesis

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Cullin-RING Ligases and Protein Neddylation

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1217))

Abstract

Cullin-RING ligase 4 (CRL4), a member of the cullin-RING ligase family, orchestrates a variety of critical cellular processes and pathophysiological events. Recent results from mouse genetics, clinical analyses, and biochemical studies have revealed the impact of CRL4 in development and cancer etiology and elucidated its in-depth mechanism on catalysis of ubiquitination as a ubiquitin E3 ligase. Here, we summarize the versatile roles of the CRL4 E3 ligase complexes in tumorigenesis dependent on the evidence obtained from knockout and transgenic mouse models as well as biochemical and pathological studies.

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Abbreviations

6-4PP:

6-4 photoproduct

APC:

Anaphase-promoting complex

BRCA1:

Breast cancer 1

CAND1:

Cullin-associated NEDD8-dissociated protein 1

Cbl:

Casitas B-lineage lymphoma

CDC25A:

Cell division cycle 25A

CDT1:

Chromatin licensing and DNA replication factor 1

CHIP:

Carboxyl terminus of Hsc70-interacting protein

CK1:

Casein kinase 1α

COP1:

Constitutive photomorphogenesis protein 1

CPD:

Cyclobutane pyrimidine dimer

CRBN:

Cereblon

CRL4:

Cullin-RING ligase 4

CSN5:

COP9 signalosome subunit 5

DCAFs:

DDB1-CUL4-associated factors

DDB1:

UV-damaged DNA-binding protein 1

DDB2:

UV-damaged DNA-binding protein 2

EloB/C:

Elongin B/C

ETV5:

E26 transformation-specific variant 5

GNB:

G protein subunit beta

Gnb3 :

G protein subunit beta 3

GRK2:

G protein-coupled receptor kinase 2

GS:

Glutamine synthetase

GSPT1:

G1-to-S phase transition 1

HBO1:

Histone acetyltransferase

HBx:

Hepatitis B virus X protein

HECT:

Homologous to the E6AP carboxyl terminus

HMSN:

Axonal hereditary motor and sensory neuropathy

HOX:

Homeodomain transcription factors

HSC:

Hematopoietic stem cells

IAPs:

Inhibitor of apoptosis protein

IKZF1/3:

Ikaros family zinc finger protein 1/3

KMT5A:

Lysine methyltransferase 5A

MAGE:

Melanoma antigen gene

MM:

Multiple myeloma

NEDD8:

Neural precursor cell-expressed, developmentally downregulated 8

NF2:

Neurofibromin 2

NLS:

Nuclear localization signal

NRF2:

NFE2-related factor 2

PARC:

p53-associated Parkin-like cytoplasmic protein

PML:

Promyelocytic leukemia

PPARγ:

Peroxisome proliferator-activated receptor γ

RBR:

RING-between RING-RING

RBX1:

RING box protein 1

RING:

Really interesting new gene

ROC1:

Regulator of cullins 1

SET8:

Set domain histone methyltransferase-8

SMC:

Structural maintenance of chromosomes

ßTrCP:

Beta-transducin repeat containing

UPS:

Ubiquitin-proteasome system

VHL:

von Hippel-Lindau tumor-suppressor protein

VprBP:

Vpr (HIV-1) binding protein

WDR:

WD repeat-containing protein

WDR4:

WD repeat domain 4

WSS:

Woodhouse-Sakati syndrome

XLMR:

X-linked mental retardation

XPC:

Xeroderma pigmentosum group C protein

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology and Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    Zhuan Zhou, Xinxin Song, Cindy M. Wavelet & Yong Wan

  2. Robert H. Lurie Comprehensive Cancer Center, Lurie Medical Research Center, Chicago, IL, USA

    Zhuan Zhou, Xinxin Song, Cindy M. Wavelet & Yong Wan

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  1. Zhuan Zhou
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  2. Xinxin Song
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  3. Cindy M. Wavelet
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  4. Yong Wan
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Correspondence to Yong Wan .

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Editors and Affiliations

  1. Radiation Oncology, University of Michigan, Ann Arbor, MI, USA

    Yi Sun

  2. Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

    Wenyi Wei

  3. Life Science Institute, Zhejiang University, Hangzhou, China

    Jianping Jin

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Zhou, Z., Song, X., Wavelet, C.M., Wan, Y. (2020). Cullin 4-DCAF Proteins in Tumorigenesis. In: Sun, Y., Wei, W., Jin, J. (eds) Cullin-RING Ligases and Protein Neddylation. Advances in Experimental Medicine and Biology, vol 1217. Springer, Singapore. https://doi.org/10.1007/978-981-15-1025-0_15

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