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TRPC Channel Downstream Signaling Cascades

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Transient Receptor Potential Canonical Channels and Brain Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 976))

  • 2017 Accesses

Abstract

The family of TRP channel is comprised of a large group of cation-permeable channels, displaying as signaling integrators for sensing extracellular stimulus and initiating intracellular signaling cascades. This chapter offers a brief review of the signaling molecules related to TRPC channels, the first identified mammalian TRP family. Besides the signaling molecules involved in TRPC activation, I will focus on their upstream and downstream signaling cascades and the molecules involved in their intracellular trafficking.

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  1. Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA

    Zhuohao He

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  1. Center of Cognition and Brain Science, Institute of Basic Medical Science, Beijing, China

    Yizheng Wang

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He, Z. (2017). TRPC Channel Downstream Signaling Cascades. In: Wang, Y. (eds) Transient Receptor Potential Canonical Channels and Brain Diseases. Advances in Experimental Medicine and Biology, vol 976. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1088-4_3

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