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The Structure and Function of the Adenovirus Major Late Promoter

  • Chapter
Adenoviruses: Model and Vectors in Virus-Host Interactions

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 272))

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Abstract

The adenovirus major late promoter (MLP) has played a preeminent role in the analysis of transcription initiation in mammalian cells, and is an outstanding example of the ways in which the study of adenovirus has led to fundamental insights into general cellular processes. The aim of this chapter is to give a comprehensive review of the structure and function of this model mammalian promoter. After a brief description of late transcription in the adenovirus replication cycle, the experimental evidence for the current consensus on the genetic structure of the MLP, including a consideration of non-primate adenovirus MLPs, will be reviewed. Next, the functions of the MLP in the viral life cycle will be examined, and some of the problems that remain to be resolved will be addressed. The review ends with some ideas on how the knowledge of the structure and function of the MLP can be used in designing virus vectors for specific experimental purposes.

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Authors and Affiliations

  1. Department of Microbiology, Columbia University, College of Physicians and Surgeons, 701W 168th Street, New York, NY, 10032, USA

    C. S. H. Young

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  1. C. S. H. Young
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  1. Institut für Klinische und Molekulare Virologie, Universität Erlangen-Nürnberg, 91054, Erlangen, Germany

    Walter Doerfler

  2. Institut für Genetik, Universität zu Köln, Weyertal 121, 50931, Köln, Germany

    Petra Böhm

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© 2003 Springer-Verlag Berlin Heidelberg

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Young, C.S.H. (2003). The Structure and Function of the Adenovirus Major Late Promoter. In: Doerfler, W., Böhm, P. (eds) Adenoviruses: Model and Vectors in Virus-Host Interactions. Current Topics in Microbiology and Immunology, vol 272. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05597-7_8

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  • DOI: https://doi.org/10.1007/978-3-662-05597-7_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-05517-1

  • Online ISBN: 978-3-662-05597-7

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