Abstract
Although many B-cell malignancies are sensitive to chemotherapy and radiotherapy and some may be cured, the majority relapse and prove fatal. Even at the extremes of dose escalation requiring bone marrow transplantation or peripheral blood stem cell rescue, there are resistant cells in many tumors that will ultimately lead to relapse. Immunotherapeutic approaches to the destruction of tumors have attracted interest because resistance to chemotherapy and radiotherapy probably does not confer resistance to immune-mediated killing. In addition, a highly selective attack on tumor cells might avoid the morbidity associated with more conventional approaches. Immunotherapy is not yet a standard part of the approach to malignancy because of the difficulties identifying antigens that are truly tumor specific and inducing a host response to these antigens. Epstein-Barr virus (EBV)-associated lymphomas present some interesting opportunities in this regard.
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Robertson, K.D., Barletta, J., Samid, D., Ambinder, R.F. (1995). Pharmacologic Activation of Expression of Immunodominant Viral Antigens: A New Strategy for the Treatment of Epstein-Barr-Virus-Associated Malignancies. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1994. Current Topics in Microbiology and Immunology, vol 194. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79275-5_18
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DOI: https://doi.org/10.1007/978-3-642-79275-5_18
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