Abstract
Burkitt’s lymphoma (BL) is a B cell neoplasm, which occurs throughout the world, predominantly in children and young adults [Magrath 1983]. Its relatively high incidence in equatorial Africa has led to the African form of the disease being designated as “endemic” (eBL), while cases outside equatorial Africa are referred to as “sporadic” (sBL) Burkitt’s lymphoma. A number of differences between eBL and sBL have been described [Magrath 1986] and are summarized in table 1.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Bentley DL and Groudine M: A block to elongation is largely responsible for decreased transcription of c-myc in differentiated HL-60 cells. Nature 1986; 321: 702–706.
Cory S: Activation of cellular oncogenes in hemopoietic cells by chromosomal translocation. Advances in Cancer Research 1986; 47: 189.
Dalla Favera R, Gellman EP, et. al.: Cloning and characterization of different human sequences related to the one gene (V-myc) of avian myelocytomatosis virus (MC-29). Proc. Nat. Acad. Sci. USA 1982; 79: 6497–6501.
Dalla Favera R, Martinotti S, et. al.: Translocation and rearrangements of the c-myc oncogene locus in human undifferentiated B-cell lymphomas. Science 1983; 219: 963–967.
Epstein MA, Achong BG, Barr YM: Virus particles in cultured lympho blasts from Burkitt’s lymphoma. Lancet 1964; 1:702–703
Hay N, Bishop MJ, Levens D.: Regulatory elements that modulate expression of human c-myc. Genes and Development 1987; 1: 659–671.
Magrath IT: Burkitt’s lymphoma: clinical aspects and treatment. In Wolander DW (ed.) Diseases of the lymphatic system. 1983 Springer Verlag, p.103.
Magrath IT: Burkitt’s lymphoma as a human tumor model: New concepts in etiology and pathogenesis. In Pediatric Hematology Oncology Reviews. Pochedly C (ed.) Praeger, Westport, 1986.pp 1–51
Pellici PG, Knowles DM, et. al.: Chromosomal breakpoints and structural alterations of the c-myc locus differ in endemic and sporadic forms of Burkitt’s lymphoma. Proc. Natl. Acad. Sci. USA 1986; 83: 2984–2988.
Zech L, Hoagland U, et al.: Characteristic chromosomal abnormalities in biopsies and lymphoid cell lines from patients with Burkitt’s and non-Burkitt’s lymphoma. Int. J. Cane. 1976; 17:47–56.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer-Verlag Berlin · Heidelberg
About this paper
Cite this paper
Barriga, F. et al. (1988). Significance of Chromosome 8 Breakpoint Location in Burkitt’s Lymphoma: Correlation with Geographical Origin and Association with Epstein-Barr Virus. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1988. Current Topics in Microbiology and Immunology, vol 141. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74006-0_18
Download citation
DOI: https://doi.org/10.1007/978-3-642-74006-0_18
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-74008-4
Online ISBN: 978-3-642-74006-0
eBook Packages: Springer Book Archive