Abstract
Like other retroviruses, human T-cell leukemia viruses (HTLV) encode envelop-antigens. The major antigen is an external glycoprotein of approximately 45000 daltons (gp45) linked (presumably by disulfide bonds) to a 21 000 dalton transmembrane protein (p21). These two proteins are cleaved from a glycosylated env precursor protein with a molecular weight at the cell surface varying between 61 000 and 69 000 daltons, according to the host cell line. These env gene products have recently been identified by Lee et al. (1984) and Schneider et al. (1984). Antibodies raised to synthetic peptides representing env gene sequences (Hattori et al. 1983) and to env-β-galactosidase hybrid proteins produced in Escherichia coli (Kiyokawa et al. 1984) precipitate env products synthesized in HTLV-infected cells.
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Weiss, R.A., Clapham, P., Nagy, K., Hoshino, H. (1985). Envelope Properties of Human T-Cell Leukemia Viruses. In: Vogt, P.K. (eds) Human T-Cell Leukemia Virus. Current Topics in Microbiology and Immunology, vol 115. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70113-9_15
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DOI: https://doi.org/10.1007/978-3-642-70113-9_15
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