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The Genetics of Murine Leukemia Viruses

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Retroviruses 3

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 112))

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Abstract

The murine leukemia viruses are prototypical replication-competent retroviruses. These viruses were among the first known oncogenic agents in mammals and have been the subjects of intensive study for more than 3 decades (Gross 1970). We now have a detailed understanding of the life cycle of these viruses and of some of the genetic effects they can have on the host cell; we are even beginning to discover how these viruses cause leukemia. Today, these viruses remain popular systems for the study of gene transfer and expression, site-specific recombination in mammalian cells, mutagenesis, and the processes of induction and progression of tumors. Most recently, their similarity to the human T-cell leukemia viruses (HTLVs) (Poiesz et al. 1982) and to sequences endogenous to the human genome (Repaske et al. 1983) has stimulated interest in a still larger scientific community.

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  1. Department of Biochemistry and Institute for Cancer Research, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, NY, 10032, USA

    S. P. Goff

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  1. Department of Microbiology, University of Southern California School of Medicine, 2025 Zonal Avenue HMR 401, Los Angeles, CA, 90033, USA

    Peter K. Vogt

  2. The Wistar Institute, 36th Street at Spruce, Philadelphia, PA, 19104, USA

    Hilary Koprowski

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Goff, S.P. (1984). The Genetics of Murine Leukemia Viruses. In: Vogt, P.K., Koprowski, H. (eds) Retroviruses 3. Current Topics in Microbiology and Immunology, vol 112. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69677-0_3

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