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Structure and Function of Respiratory Syncytial Virus Surface Glycoproteins

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Challenges and Opportunities for Respiratory Syncytial Virus Vaccines

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 372))

Abstract

The two major glycoproteins on the surface of the respiratory syncytial virus (RSV) virion, the attachment glycoprotein (G) and the fusion glycoprotein (F), control the initial phases of infection. G targets the ciliated cells of the airways, and F causes the virion membrane to fuse with the target cell membrane. The F protein is the major target for antiviral drug development, and both G and F glycoproteins are the antigens targeted by neutralizing antibodies induced by infection. In this chapter, we review the structure and function of the RSV surface glycoproteins, including recent X-ray crystallographic data of the F glycoprotein in its pre- and postfusion conformations, and discuss how this information informs antigen selection and vaccine development.

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Acknowledgments

The authors thank Supranee Chaiwatpongskorn and Jacqueline Corry for their help with the graphics. Authors are supported by NIH grants AI095684 (MEP and WCR) and AI093848 (MEP), Tibotec/Johnson & Johnson (MEP) and Cystic Fibrosis Foundation Therapeutics, Inc. (MEP).

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Authors and Affiliations

  1. Vaccine Research Center, NIAID, National Institutes of Health, Bethesda, MD, USA

    Jason S. McLellan

  2. Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children’s Hospital, Columbus, OH, USA

    William C. Ray

  3. Center for Vaccines & Immunity, The Research Institute at Nationwide Children’s Hospital, Columbus, OH, USA

    Mark E. Peeples

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  1. Jason S. McLellan
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  2. William C. Ray
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  3. Mark E. Peeples
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Correspondence to Mark E. Peeples .

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Editors and Affiliations

  1. Department of Pediatrics and Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia, USA

    Larry J. Anderson

  2. Vaccine Research Center, NIH Natl. Inst. of Allergy & Infect. Dis., Bethesda, Maryland, USA

    Barney S. Graham

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McLellan, J.S., Ray, W.C., Peeples, M.E. (2013). Structure and Function of Respiratory Syncytial Virus Surface Glycoproteins. In: Anderson, L., Graham, B. (eds) Challenges and Opportunities for Respiratory Syncytial Virus Vaccines. Current Topics in Microbiology and Immunology, vol 372. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38919-1_4

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