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SUMO, the Three Rs and Cancer

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Acute Promyelocytic Leukemia

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 313))

Abstract

SUMO modification (sumoylation) plays important roles in nucleocytoplasmic transport, maintenance of sub-nuclear architecture, the regulation of gene expression and in DNA replication, repair and recombination. Here we review recent evidence for SUMO’s role in protecting genomic integrity at both the chromosomal and the DNA level. Furthermore, the involvement of sumoylation and of specific SUMO targets in cancer is discussed.

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Authors and Affiliations

  1. Nuclear Organisation and Oncogenesis Unit, INSERM U.579, Institut Pasteur, 28 rue du Dr. Roux, 75724, Paris Cedex 15, France

    J. -S. Seeler, O. Bischof, K. Nacerddine & A. Dejean

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  1. J. -S. Seeler
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  2. O. Bischof
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  3. K. Nacerddine
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  4. A. Dejean
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  1. Memorial Sloan-Kettering Cancer Center, Sloan-Kettering-Institute, 1275 York Avenue, New York, New York, 10021, USA

    Pier Paolo Pandolfi MD, Ph.D.

  2. The Scripps Research Institute, 10550 North Torreye Pines Road, La Jolla, CA, 92037, USA

    Peter K. Vogt Ph.D.

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Seeler, J.S., Bischof, O., Nacerddine, K., Dejean, A. (2007). SUMO, the Three Rs and Cancer. In: Pandolfi, P.P., Vogt, P.K. (eds) Acute Promyelocytic Leukemia. Current Topics in Microbiology and Immunology, vol 313. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-34594-7_4

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