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Turmeric and Curcumin: From Traditional to Modern Medicine

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Studies on Biomarkers and New Targets in Aging Research in Iran

Part of the book series: Advances in Experimental Medicine and Biology ((PMISB,volume 1291))

Abstract

The rhizome of turmeric (Curcuma longa L.) has been used as an herbal medicine, coloring agent, spice, and food additive for thousands of years in different parts of the world particularly in Asian countries. It has been used for a range of diseases in many traditional medical schools, including Islamic traditional medicine, Chinese traditional medicine, and Ayurveda. It has been used mainly for digestive problems, as a cardio-, hepato-, and neuroprotective agent as well as in many inflammatory conditions such as arthritis and for enhancing immune system. Curcumin, a diarylheptanoid derivative found in turmeric, has anti-inflammatory, antioxidant, and anticancer properties; controls obesity and metabolic problems; and improves memory and mood disorders. Therapeutically, curcumin exhibits promising potential in preclinical and clinical studies and is currently in human trials for a variety of conditions, including metabolic syndrome, nonalcoholic fatty liver disease, rheumatoid arthritis, migraine, premenstrual syndrome, ulcerative colitis, knee osteoarthritis, polycystic ovarian syndrome, atherosclerosis, liver cirrhosis, amyotrophic lateral sclerosis, depression, psoriasis, and Alzheimer’s disease. Among all beneficial activities reported for curcumin, the research toward the obesity and metabolic-preventing/suppressing aspects of curcumin is growing. These findings emphasize that most of the traditional applications of turmeric is due to the presence of its key constituent, curcumin. According to the traditional background of turmeric use and clinical values of curcumin, further preclinical studies for unstudied properties and clinical studies with larger sample sizes for confirmed activities are expected.

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References

  1. Moreira J, Saraiva L, Pinto MM, Cidade H (2020) Diarylpentanoids with antitumor activity: a critical review of structure-activity relationship studies. Eur J Med Chem 92:112177. https://doi.org/10.1016/j.ejmech.2020.112177

    Article  CAS  Google Scholar 

  2. Hatamipour M, Ramezani M, Tabassi SAS, Johnston TP, Sahebkar A (2019) Demethoxycurcumin: a naturally occurring curcumin analogue for treating non-cancerous diseases. J Cell Physiol 234(11):19320–19330

    Article  CAS  PubMed  Google Scholar 

  3. Mollazadeh H, Cicero AFG, Blesso CN, Pirro M, Majeed M, Sahebkar A (2019) Immune modulation by curcumin: the role of interleukin-10. Crit Rev Food Sci Nutr 59(1):89–101

    Google Scholar 

  4. Hasanzadeh S, Read MI, Bland AR, Majeed M, Jamialahmadi T, Sahebkar A (2020) Curcumin: an inflammasome silencer. Pharmacol Res 159:104921. https://doi.org/10.1016/j.phrs.2020.104921. Epub 2020 May 25. PMID: 32464325

  5. Abdollahi E, Momtazi AA, Johnston TP, Sahebkar A (2018) Therapeutic effects of curcumin in inflammatory and immunemediated diseases: a nature-made jack-of-all-trades? J Cell Physiol 233(2):830–848

    Google Scholar 

  6. Boroumand N, Samarghandian S, Hashemy SI (2018) Immunomodulatory, anti-inflammatory, and antioxidant effects of curcumin. J Herb Med Pharmacol 7(4):211–219

    Article  CAS  Google Scholar 

  7. Panahi Y, Ahmadi Y, Teymouri M, Johnston TP, Sahebkar A (2017) Curcumin as a potential candidate for treating hyperlipidemia: A review of cellular and metabolic mechanisms. J Cell Physiol 233(1):141–152. https://doi.org/10.1002/jcp.25756. Epub 2017 Jun 6. PMID: 28012169

  8. Naz RK, Lough ML, Barthelmess EK (2016) Curcumin: a novel non-steroidal contraceptive with antimicrobial properties. Front Biosci (Elite Ed) 8(1):113–128

    Article  Google Scholar 

  9. Teymouri M, Pirro M, Johnston TP, Sahebkar A (2017) Curcumin as a multifaceted compound against human papilloma virus infection and cervical cancers: A review of chemistry, cellular, molecular, and preclinical features. BioFactors 43(3):331–346.

    Google Scholar 

  10. Mohajeri M, Bianconi V, Ávila-Rodriguez MF, Barreto GE, Jamialahmadi T, Pirro M, Sahebkar A (2020) Curcumin: a phytochemical modulator of estrogens and androgens in tumors of the reproductive system. Pharmacol Res 156:104765. https://doi.org/10.1016/j.phrs.2020.104765. Epub 2020 Mar 23. PMID: 32217147

  11. Doello K, Ortiz R, Alvarez PJ, Melguizo C, Cabeza L, Prados J (2018) Latest in vitro and in vivo assay, clinical trials and patents in cancer treatment using curcumin: a literature review. Nutr Cancer 70(4):569–578

    Article  CAS  PubMed  Google Scholar 

  12. Iranshahi M, Sahebkar A, Hosseini ST, Takasaki M, Konoshima T, Tokuda H (2010) Cancer chemopreventive activity of diversin from Ferula diversivittata in vitro and in vivo. Phytomedicine 17(3-4):269–273. https://doi:10.1016/j.phymed.2009.05.020. Epub 2009 Jul3. PMID: 19577457

  13. Kolivand S, Amini P, Saffar H, Rezapoor S, Motevaseli E, Najafi M et al (2019) Evaluating the radioprotective effect of curcumin on rat’s heart tissues. Curr Radiopharm 12(1):23–28

    Article  CAS  PubMed  Google Scholar 

  14. Forouzanfar F, Read MI, Barreto GE, Sahebkar A (2020) Neuroprotective effects of curcumin through autophagy modulation. IUBMB Life 72(4):652–664

    Article  CAS  PubMed  Google Scholar 

  15. Panahi Y, Kianpour P, Mohtashami R, Jafari R, Simental-Mendía LE, Sahebkar A (2017) Efficacy and Safety of Phytosomal Curcumin in Non-Alcoholic Fatty Liver Disease: A Randomized Controlled Trial. Drug Res (Stuttg) 67(4):244–251. https://doi.org/10.1055/s-0043-100019. Epub 2017 Feb 3. PMID: 28158893.

  16. Abd El-Kader M, Taha RI (2020) Comparative nephroprotective effects of curcumin and etoricoxib against cisplatin-induced acute kidney injury in rats. Acta Histochem 122(4):151534. https://doi.org/10.1016/j.acthis.2020.151534

    Article  CAS  PubMed  Google Scholar 

  17. Aslanabadi N, Entezari-Maleki T, Rezaee H, Jafarzadeh HR, Vahedpour R (2019) Curcumin for the prevention of myocardial injury following elective percutaneous coronary intervention; a pilot randomized clinical trial. Eur J Pharmacol 858:172471. https://doi.org/10.1016/j.ejphar.2019.172471

    Article  CAS  PubMed  Google Scholar 

  18. Saberi-Karimian M, Keshvari M, Ghayour-Mobarhan M, Salehizadeh L, Rahmani S, Behnam B, Jamialahmadi T, Asgary S, Sahebkar A (2020) Effects of curcuminoids on inflammatory status in patients with non-alcoholic fatty liver disease: A randomized controlled trial. Complementary Therapies in Medicine 49, 102322. https://doi.org/10.1016/j.ctim.2020.102322 

  19. Alvarenga L, Salarolli R, Cardozo LFMF, Santos RS, de Brito JS, Kemp JA, Reis D, de Paiva BR, Stenvinkel P, Lindholm B, Fouque D, Mafra D (2020) Impact of curcumin supplementation on expression of inflammatory transcription factors in hemodialysis patients: a pilot randomized, double-blind, controlled study. Clin Nutr. S0261-5614(20)30110-2. https://doi.org/10.1016/j.clnu.2020.03.007

  20. Soltani A, Salmaninejad A, Jalili-Nik M, Soleimani A, Javid H, Hashemy SI et al (2019) 5′-adenosine monophosphate-activated protein kinase: a potential target for disease prevention by curcumin. J Cell Physiol 234(3):2241–2251

    Article  CAS  PubMed  Google Scholar 

  21. Saberi-Karimian M, Katsiki N, Caraglia M, Boccellino M, Majeed M, Sahebkar A (2019) Vascular endothelial growth factor: an important molecular target of curcumin. Crit Rev Food Sci Nutr 59(2):299–312

    Article  CAS  PubMed  Google Scholar 

  22. Momtazi AA, Derosa G, Maffioli P, Banach M, Sahebkar A (2016) Role of microRNAs in the therapeutic effects of curcumin in non-cancer diseases. Mol Diagn Ther 20(4):335–345

    Google Scholar 

  23. Prasad S, Aggarwal BB (2011) Turmeric, the golden spice: from traditional medicine to modern medicine. In: Benzie IFF, Wachtel-Galor S (eds) Herbal medicine: biomolecular and herbal medicine: biomolecular and clinical aspects, 2nd edn. CRC Press/Taylor & Francis, Boca Raton, FL, pp 263–288

    Chapter  Google Scholar 

  24. Rāzi MZ (1968) In: Khān A (ed) Al-Ḥāwi fi’l-Ṭibb (comprehensive book of medicine, in Arabic), vol 31. Osmania Oriental Publications Bureau, Osmania University, Hyderabad

    Google Scholar 

  25. Ibn Sinā A (1987) Al-Qānun fi’l-Ṭibb (canon of medicine, in Arabic), vol 2. I.H.M.M.R. Printing Press, New Delhi

    Google Scholar 

  26. Herawi M (1967) In: Bahmānyar A (ed) Al-Abniyah an Ḥaqāyeq al-Adwiyah (basics of realities on drugs, in Persian). Tehran University Publications, Tehran, Iran

    Google Scholar 

  27. Ibn Jazlah Y (1631) Minhāj al-Bayān fīmā Yastaʿmiluhū al-Insān (in Arabic). League of Arab States, Bulaq, Cairo, Egypt

    Google Scholar 

  28. Ibn Beyṭār Z (2001) Al-Jameʿe le-Mofradāt al-Adwiah wal-Aghdhiyah (comprehensive book in simple drugs and foods in Arabic), vol 2. Dār al-Kūtūb al-ʿElmiyah, Beirut, Lebanon

    Google Scholar 

  29. Anṭāki D (2000) In: Shams a’ddin A (ed) Tadhkereh Oulūl-albāb (memorandum book, in Arabic). Dār-al-Kūtūb al-ʿElmiyah, Beirut, Lebanon

    Google Scholar 

  30. Tonekāboni MM (1959) Toḥfat al-Momenin (rarity of the faithful, in Persian). Mostafavi Press, Tehran, Iran

    Google Scholar 

  31. Ghasāni AM (1985) Ḥadiqat al-Azhār fi Māhiyyat al-ʿUshb wa al-ʿUqqār (Flower Garden in the Nature of Herbs and Drugs,in Arabic). Dār al-Gharb al-Islāmi, Beirut, Lebanon

    Google Scholar 

  32. Aqili Khorāsāni MH (1992) Makhzan al-Adwiah (Drug Treasure, in Persian). Reprinted from a copy which was printed in Calcutta dated in 1844. Enqelab-e Eslami Publishing and Educational Organization, Tehran, Iran

    Google Scholar 

  33. Jorjāni SI (1977) In: Saeedi Sirjani AA (ed) Dhakhireh Khārazmshāhi, (treasure of Khārazmshāh, in Persian), photoprint of the manuscript dated 1206 AD. The lranian Culture Foundation, Tehran, Iran

    Google Scholar 

  34. Herawi MY (2008) Baḥr al-Jawāher (Sea of Gems, in Arabic). Institute of Revival of Natural Medicine, Qom

    Google Scholar 

  35. Qorashi AA (607-687 AH/1211-1288 AD) al-Shāmel (The comprehensive, in Arabic). Vol. 19. Al Majmaʿ al-Thaqāfi. Abu-Dhabi, United Arab Emirates

    Google Scholar 

  36. Jorjāni SI (2006) Al-Aghrāḍ al-Ṭibbia wal Mabāheth al-ʿAlāiia (Medical Purposes and al-Alȃee Investigations,in Persian), vol 1. Tehran University Publication, Tehran, Iran

    Google Scholar 

  37. Ayati Z, Ramezani M, Amiri MS, Moghadam AT, Rahimi H, Abdollahzade A et al (2019) Ethnobotany, phytochemistry and traditional uses of Curcuma spp. and pharmacological profile of two important species (C. longa and C. zedoaria): a review. Curr Pharm Des 25(8):871–935

    Article  CAS  PubMed  Google Scholar 

  38. Vasanthi HR, Parameswari RP (2010) Indian spices for healthy heart - an overview. Curr Cardiol Rev 6(4):274–279

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Duggi S, Harish H, Handral R, Tulsianand G, Shruthi SD (2013) Turmeric: nature’s precious medicine. Asian J Pharm Clin Res 6(3):10–16

    Google Scholar 

  40. Samala S, Veeresham C (2017) Ethnobotany of turmeric and its medicinal importance. In: Ethnobotany of India. Volume 3: North-East India and the Andaman and Nicobar Islands. CRC Press/Taylor & Francis, Boca Raton, FL, pp 293–316

    Google Scholar 

  41. Bone K, Mills S (2012) Principles and practice of phytotherapy: modern herbal medicine. Principles and practice of phytotherapy, 2nd edn. Elsevier, Austin, TX, pp 900–918

    Google Scholar 

  42. Khanna NM (1999) Turmeric – Nature’s precious gift. Curr Sci 76(10):1351–1356

    Google Scholar 

  43. Kawasaki K, Fukuhara I, Muroyama K, Murosaki S (2017) Effect of a combination of hot water extract of Curcuma longa and curcumin on serum liver enzymes, inflammatory markers, and emotional states in healthy participants with moderately high body mass index: a randomized, double-blind, placebo-controlled clinical trial. Jpn Pharmacol Ther 45(2):243–252

    CAS  Google Scholar 

  44. Vafadar Afshar G, Rasmi Y, Yagmayee P, Khadem-Ansari MH, Makhdomii K, Rasooli J (2020) The effects of nano-curcumin supplementation on serum level of hs-CRP, adhesion molecules, and lipid profiles in hemodialysis patients, a randomized controlled clinical trial. Iran J Kidney Dis 14(1):52–61

    PubMed  Google Scholar 

  45. Javadi M, Khadem Haghighian H, Goodarzy S, Abbasi M, Nassiri-Asl M (2019) Effect of curcumin nanomicelle on the clinical symptoms of patients with rheumatoid arthritis: a randomized, double-blind, controlled trial. Int J Rheum Dis 22(10):1857–1862

    Article  CAS  PubMed  Google Scholar 

  46. Abdolahi M, Jafarieh A, Sarraf P, Sedighiyan M, Yousefi A, Tafakhori A et al (2019) The neuromodulatory effects of ω-3 fatty acids and nano-curcumin on the COX-2/iNOS network in migraines: a clinical trial study from gene expression to clinical symptoms. Endocr Metab Immune Disord Drug Targets 19(6):874–884

    Article  CAS  PubMed  Google Scholar 

  47. Abdolahi M, Sarraf P, Javanbakht MH, Honarvar NM, Hatami M, Soveyd N et al (2018) A novel combination of ω-3 fatty acids and nano-curcumin modulates interleukin-6 gene expression and high sensitivity C-reactive protein serum levels in patients with migraine: a randomized clinical trial study. CNS Neurol Disord Drug Targets 17(6):430–438

    Article  CAS  PubMed  Google Scholar 

  48. Parohan M, Sarraf P, Javanbakht MH, Foroushani AR, Ranji-Burachaloo S, Djalali M (2019) The synergistic effects of nano-curcumin and coenzyme Q10 supplementation in migraine prophylaxis: a randomized, placebo-controlled, double-blind trial. Nutr Neurosci:1–10. https://doi.org/10.1080/1028415X.2019.1627770

  49. Khayat S, Fanaei H, Kheirkhah M, Moghadam ZB, Kasaeian A, Javadimehr M (2015) Curcumin attenuates severity of premenstrual syndrome symptoms: a randomized, double-blind, placebo-controlled trial. Complement Ther Med 23(3):318–324

    Article  PubMed  Google Scholar 

  50. Afshariani R, Farhadi P, Ghaffarpasand F, Roozbeh J (2014) Effectiveness of topical curcumin for treatment of mastitis in breastfeeding women: a randomized, double-blind, placebo-controlled clinical trial. Oman Med J 29(5):330–334

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Ryan JL, Heckler CE, Ling M, Katz A, Williams JP, Pentland AP et al (2013) Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients. Radiat Res 180(1):34–43

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Ataei-Almanghadim K, Farshbaf-Khalili A, Ostadrahimi AR, Shaseb E, Mirghafourvand M (2020) The effect of oral capsule of curcumin and vitamin E on the hot flashes and anxiety in postmenopausal women: a triple blind randomised controlled trial. Complement Ther Med 48:102267. https://doi.org/10.1016/j.ctim.2019.102267

    Article  PubMed  Google Scholar 

  53. Masoodi M, Mahdiabadi MA, Mokhtare M, Agah S, Kashani AHF, Rezadoost AM et al (2018) The efficacy of curcuminoids in improvement of ulcerative colitis symptoms and patients’ self-reported well-being: a randomized double-blind controlled trial. J Cell Biochem 119(11):9552–9559

    Article  CAS  PubMed  Google Scholar 

  54. Panahi Y, Ghanei M, Bashiri S, Hajihashemi A, Sahebkar A (2014) Short-term curcuminoid supplementation for chronic pulmonary complications due to sulfur mustard intoxication: positive results of a randomized double-blind placebo-controlled trial. Drug Res 65(11):567–573

    Article  CAS  Google Scholar 

  55. Panahi Y, Ghanei M, Hajhashemi A, Sahebkar A (2016) Effects of curcuminoids-piperine combination on systemic oxidative stress, clinical symptoms and quality of life in subjects with chronic pulmonary complications due to sulfur mustard: a randomized controlled trial. J Diet Suppl 13(1):93–105

    Article  CAS  PubMed  Google Scholar 

  56. Azhdari M, Karandish M, Mansoori A (2019) Metabolic benefits of curcumin supplementation in patients with metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials. Phytother Res 33(5):1289–1301

    Article  CAS  PubMed  Google Scholar 

  57. Panahi Y, Rahimnia AR, Sharafi M, Alishiri G, Saburi A, Sahebkar A (2014) Curcuminoid treatment for knee osteoarthritis: a randomized double-blind placebo-controlled trial. Phytother Res 28(11):1625–1631

    Article  CAS  PubMed  Google Scholar 

  58. Pinsornsak P, Niempoog S (2012) The efficacy of Curcuma longa L. extract as an adjuvant therapy in primary knee osteoarthritis: a randomized control trial. J Med Assoc Thail 95(Suppl 1):S51–S58

    Google Scholar 

  59. Panahi Y, Sahebkar A, Amiri M, Davoudi SM, Beiraghdar F, Hoseininejad SL et al (2012) Improvement of Sulphur mustard-induced chronic pruritus, quality of life and antioxidant status by curcumin: results of a randomised, double-blind, placebo-controlled trial. Br J Nutr 108(7):1272–1279

    Article  CAS  PubMed  Google Scholar 

  60. White CM, Pasupuleti V, Roman YM, Li Y, Hernandez AV (2019) Oral turmeric/curcumin effects on inflammatory markers in chronic inflammatory diseases: a systematic review and meta-analysis of randomized controlled trials. Pharmacol Res 146:104280. https://doi.org/10.1016/j.phrs.2019.104280

    Article  CAS  PubMed  Google Scholar 

  61. Heshmati J, Golab F, Morvaridzadeh M, Potter E, Akbari-Fakhrabadi M, Farsi F et al (2020) The effects of curcumin supplementation on oxidative stress, Sirtuin-1 and peroxisome proliferator activated receptor γ coactivator 1α gene expression in polycystic ovarian syndrome (PCOS) patients: a randomized placebo-controlled clinical trial. Diabetes Metab Syndr 14(2):77–82

    Article  PubMed  Google Scholar 

  62. Fleenor BS, Carlini NA, Campbell MS (2019) Curcumin and arterial function in health and disease: impact on oxidative stress and inflammation. Curr Opin Clin Nutr Metab Care 22(6):459–464

    Article  CAS  PubMed  Google Scholar 

  63. Jin T (2019) Mechanisms underlying the metabolic beneficial effect of curcumin intervention: beyond anti-inflammation and anti-oxidative stress. Obes Med 13:1–5

    Article  CAS  Google Scholar 

  64. Tabrizi R, Vakili S, Akbari M, Mirhosseini N, Lankarani KB, Rahimi M et al (2019) The effects of curcumin-containing supplements on biomarkers of inflammation and oxidative stress: a systematic review and meta-analysis of randomized controlled trials. Phytother Res 33(2):253–262

    Article  CAS  PubMed  Google Scholar 

  65. Qin S, Huang L, Gong J, Shen S, Huang J, Tang Y et al (2018) Meta-analysis of randomized controlled trials of 4 weeks or longer suggest that curcumin may afford some protection against oxidative stress. Nutr Res 60:1–12

    Article  CAS  PubMed  Google Scholar 

  66. Akbari M, Lankarani KB, Tabrizi R, Ghayour-Mobarhan M, Peymani P, Ferns G et al (2019) The effects of curcumin on weight loss among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials. Front Pharmacol 10:649. https://doi.org/10.3389/fphar.2019.00649

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  67. Di Pierro F, Bressan A, Ranaldi D, Rapacioli G, Giacomelli L, Bertuccioli A (2015) Potential role of bioavailable curcumin in weight loss and omental adipose tissue decrease: preliminary data of a randomized, controlled trial in overweight people with metabolic syndrome. Eur Rev Med Pharmacol Sci 19(21):4195–4202

    PubMed  Google Scholar 

  68. Jalali M, Mahmoodi M, Mosallanezhad Z, Jalali R, Imanieh MH, Moosavian SP (2020) The effects of curcumin supplementation on liver function, metabolic profile and body composition in patients with non-alcoholic fatty liver disease: a systematic review and meta-analysis of randomized controlled trials. Complement Ther Med 48:102283. https://doi.org/10.1016/j.ctim.2019.102283

    Article  PubMed  Google Scholar 

  69. Wei Z, Liu N, Tantai X, Xing X, Xiao C, Chen L et al (2019) The effects of curcumin on the metabolic parameters of non-alcoholic fatty liver disease: a meta-analysis of randomized controlled trials. Hepatol Int 13(3):302–313

    Google Scholar 

  70. Jazayeri-Tehrani SA, Rezayat SM, Mansouri S, Qorbani M, Alavian SM, Daneshi-Maskooni M et al (2019) Nano-curcumin improves glucose indices, lipids, inflammation, and Nesfatin in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD): a double-blind randomized placebo-controlled clinical trial. Nutr Metab (Lond) 16:8. https://doi.org/10.1186/s12986-019-0331-1

    Article  Google Scholar 

  71. Melo ISVD, Santos AFD, Bueno NB (2018) Curcumin or combined curcuminoids are effective in lowering the fasting blood glucose concentrations of individuals with dysglycemia: systematic review and meta-analysis of randomized controlled trials. Pharmacol Res 128:137–144

    Article  PubMed  CAS  Google Scholar 

  72. Na LX, Li Y, Pan HZ, Zhou XL, Sun DJ, Meng M et al (2013) Curcuminoids exert glucose-lowering effect in type 2 diabetes by decreasing serum free fatty acids: a double-blind, placebo-controlled trial. Mol Nutr Food Res 57(9):1569–1577

    Article  CAS  PubMed  Google Scholar 

  73. Baziar N, Parohan M (2020) The effects of curcumin supplementation on body mass index, body weight, and waist circumference in patients with nonalcoholic fatty liver disease: a systematic review and dose-response meta-analysis of randomized controlled trials. Phytother Res 34(3):464–474

    Article  CAS  PubMed  Google Scholar 

  74. Campbell MS, Ouyang A, Krishnakumar IM, Charnigo RJ, Westgate PM, Fleenor BS (2019) Influence of enhanced bioavailable curcumin on obesity-associated cardiovascular disease risk factors and arterial function: a double-blinded, randomized, controlled trial. Nutrition 62:135–139

    Article  CAS  PubMed  Google Scholar 

  75. Saraf-Bank S, Ahmadi A, Paknahad Z, Maracy M, Nourian M (2019) Effects of curcumin on cardiovascular risk factors in obese and overweight adolescent girls: a randomized clinical trial. Sao Paulo Med J 137(5):414–422

    Article  PubMed  Google Scholar 

  76. Qin S, Huang L, Gong J, Shen S, Huang J, Ren H et al (2017) Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: a meta-analysis of randomized controlled trials. Nutr J 16(1):68. https://doi.org/10.1186/s12937-017-0293-y

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  77. Tabrizi R, Vakili S, Lankarani KB, Akbari M, Mirhosseini N, Ghayour-Mobarhan M et al (2018) The effects of curcumin on glycemic control and lipid profiles among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials. Curr Pharm Des 24(27):3184–3199

    Article  CAS  PubMed  Google Scholar 

  78. Poolsup N, Suksomboon N, Kurnianta PDM, Deawjaroen K (2019) Effects of curcumin on glycemic control and lipid profile in prediabetes and type 2 diabetes mellitus: a systematic review and meta-analysis. PLoS One 14(4):e0215840. https://doi.org/10.1371/journal.pone.0215840

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  79. Clark CCT, Ghaedi E, Arab A, Pourmasoumi M, Hadi A (2019) The effect of curcumin supplementation on circulating adiponectin: a systematic review and meta-analysis of randomized controlled trials. Diabetes Metab Syndr 13(5):2819–2825

    Article  PubMed  Google Scholar 

  80. Goodarzi R, Sabzian K, Shishehbor F, Mansoori A (2019) Does turmeric/curcumin supplementation improve serum alanine aminotransferase and aspartate aminotransferase levels in patients with nonalcoholic fatty liver disease? A systematic review and meta-analysis of randomized controlled trials. Phytother Res 33(3):561–570

    Article  CAS  PubMed  Google Scholar 

  81. Mousavi SM, Milajerdi A, Varkaneh HK, Gorjipour MM, Esmaillzadeh A (2020) The effects of curcumin supplementation on body weight, body mass index and waist circumference: a systematic review and dose-response meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr 60(1):171–180

    Article  CAS  PubMed  Google Scholar 

  82. Fan C, Song Q, Wang P, Li Y, Yang M, Yu SY (2019) Neuroprotective effects of curcumin on IL-1β-induced neuronal apoptosis and depression-like behaviors caused by chronic stress in rats. Front Cell Neurosci 12:516. https://doi.org/10.3389/fncel.2018.00516

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  83. Zhu LN, Mei X, Zhang ZG, Xie YP, Lang F (2019) Curcumin intervention for cognitive function in different types of people: a systematic review and meta-analysis. Phytother Res 33(3):524–533

    Article  PubMed  Google Scholar 

  84. Ng QX, Koh SSH, Chan HW, Ho CYX (2017) Clinical use of curcumin in depression: a meta-analysis. J Am Med Dir Assoc 18(6):503–508

    Article  PubMed  Google Scholar 

  85. Al-Karawi D, Al Mamoori DA, Tayyar Y (2016) The role of curcumin administration in patients with major depressive disorder: mini meta-analysis of clinical trials. Phytother Res 30(2):175–183

    Article  CAS  PubMed  Google Scholar 

  86. Fusar-Poli L, Vozza L, Gabbiadini A, Vanella A, Concas I, Tinacci S et al (2020) Curcumin for depression: a meta-analysis. Crit Rev Food Sci Nutr 60(15):2643–2653

    Article  CAS  PubMed  Google Scholar 

  87. Tayarani-Najaran Z, Tayarani N, Emami SA (2014) The history of islamic medicine at a glance. In: Watson RR, Preedy VR, Zibadi S (eds) Polyphenols in human health and disease. Academic Press, San Diego, CA, pp 17–27

    Chapter  Google Scholar 

  88. Phoolcharoen N, Oranratanaphan S, Ariyasriwatana C, Worasethsin P (2019) Efficacy of curcuminoids for reducing postoperative pain after laparoscopic gynecologic surgery: a pilot randomized trial. J Complement Integr Med 16(4):20180224. https://doi.org/10.1515/jcim-2018-0224

    Article  CAS  Google Scholar 

  89. Zoodfekr L, Matinhomai H, Tarverdizadeh B (2017) The effect of aerobic exercise and curcumin consumption on clinical signs and serum levels of sexual hormones in 18-35 year-old women with premenstrual syndrome: a randomized clinical trial. Iran J Obstet Gynecol Infertil 20(8):70–79

    Google Scholar 

  90. Shao N, Jia H, Li Y, Li J (2017) Curcumin improves treatment outcome of Takayasu arteritis patients by reducing TNF-α: a randomized placebo-controlled double-blind clinical trial. Immunol Res 65(4):969–974

    Article  CAS  PubMed  Google Scholar 

  91. Ganjali S, Sahebkar A, Mahdipour E, Jamialahmadi K, Torabi S, Akhlaghi S et al (2014) Investigation of the effects of curcumin on serum cytokines in obese individuals: a randomized controlled trial. ScientificWorldJournal 2014:898361. https://doi.org/10.1155/2014/898361

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  92. Panahi Y, Saadat A, Beiraghdar F, Sahebkar A (2014) Adjuvant therapy with bioavailability-boosted curcuminoids suppresses systemic inflammation and improves quality of life in patients with solid tumors: a randomized double-blind placebo-controlled trial. Phytother Res 28(10):1461–1467

    Article  CAS  PubMed  Google Scholar 

  93. Panahi Y, Sahebkar A, Parvin S, Saadat A (2012) A randomized controlled trial on the anti-inflammatory effects of curcumin in patients with chronic sulphur mustard-induced cutaneous complications. Annal Clin Biochem 49(6):580–588

    Article  CAS  Google Scholar 

  94. Saraf-Bank S, Ahmadi A, Paknahad Z, Maracy M, Nourian M (2019) Effects of curcumin supplementation on markers of inflammation and oxidative stress among healthy overweight and obese girl adolescents: a randomized placebo-controlled clinical trial. Phytother Res 33(8):2015–2022

    Article  CAS  PubMed  Google Scholar 

  95. Alizadeh F, Javadi M, Karami AA, Gholaminejad F, Kavianpour M, Haghighian HK (2018) Curcumin nanomicelle improves semen parameters, oxidative stress, inflammatory biomarkers, and reproductive hormones in infertile men: a randomized clinical trial. Phytother Res 32(3):514–521

    Article  CAS  PubMed  Google Scholar 

  96. Nasseri E, Mohammadi E, Tamaddoni A, Qujeq D, Zayeri F, Zand H (2017) Benefits of curcumin supplementation on antioxidant status in β-thalassemia major patients: a double-blind randomized controlled clinical trial. Ann Nutr Metab 71(3–4):136–144

    Article  CAS  PubMed  Google Scholar 

  97. Panahi Y, Khalili N, Sahebi E, Namazi S, Karimian MS, Majeed M et al (2017) Antioxidant effects of curcuminoids in patients with type 2 diabetes mellitus: a randomized controlled trial. Inflammopharmacology 25(1):25–31

    Article  CAS  PubMed  Google Scholar 

  98. Panahi Y, Alishiri GH, Parvin S, Sahebkar A (2016) Mitigation of systemic oxidative stress by curcuminoids in osteoarthritis: results of a randomized controlled trial. J Diet Suppl 13(2):209–220

    Article  CAS  PubMed  Google Scholar 

  99. Panahi Y, Saadat A, Beiraghdar F, Hosseini Nouzari SM, Jalalian HR, Sahebkar A (2014) Antioxidant effects of bioavailability-enhanced curcuminoids in patients with solid tumors: a randomized double-blind placebo-controlled trial. J Funct Foods 6(1):615–622

    Article  CAS  Google Scholar 

  100. Leite DPV, Paolillo FR, Parmesano TN, Fontana CR, Bagnato VS (2014) Effects of photodynamic therapy with blue light and curcumin as mouth rinse for oral disinfection: a randomized controlled trial. Photomed Laser Surg 32(11):627–632

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  101. Raghava KV, Sistla KP, Narayan SJ, Yadalam U, Bose A, Mitra K (2019) Efficacy of curcumin as an adjunct to scaling and root planing in chronic periodontitis patients: a randomized controlled clinical trial. J Contemp Dent Pract 20(7):842–846

    Article  PubMed  Google Scholar 

  102. Jamilian M, Foroozanfard F, Kavossian E, Aghadavod E, Shafabakhsh R, Hoseini A et al (2020) Effects of curcumin on body weight, glycemic control and serum lipids in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Clin Nutr ESPEN 36:128–133

    Article  PubMed  Google Scholar 

  103. Sohaei S, Amani R, Tarrahi MJ, Ghasemi-Tehrani H (2019) The effects of curcumin supplementation on glycemic status, lipid profile and hs-CRP levels in overweight/obese women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled clinical trial. Complement Ther Med 47:102201. https://doi.org/10.1016/j.ctim.2019.102201

    Article  PubMed  Google Scholar 

  104. Chuengsamarn S, Rattanamongkolgul S, Phonrat B, Tungtrongchitr R, Jirawatnotai S (2014) Reduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: a randomized controlled trial. J Nutr Biochem 25(2):144–150

    Article  CAS  PubMed  Google Scholar 

  105. Safarian H, Parizadeh SMR, Saberi-Karimain M, Darroudi S, Javandoost A, Mohammadi F et al (2019) The effect of curcumin on serum copper and zinc and Zn/cu ratio in individuals with metabolic syndrome: a double-blind clinical trial. J Diet Suppl 16(6):625–634

    Article  CAS  PubMed  Google Scholar 

  106. Hodaei H, Adibian M, Nikpayam O, Hedayati M, Sohrab G (2019) The effect of curcumin supplementation on anthropometric indices, insulin resistance and oxidative stress in patients with type 2 diabetes: a randomized, double-blind clinical trial. Diabetol Metab Syndr 11:41. https://doi.org/10.1186/s13098-019-0437-7

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  107. Cicero AFG, Sahebkar A, Fogacci F, Bove M, Giovannini M, Borghi C (2020) Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial. Eur J Nutr 59(2):477–483

    Article  CAS  PubMed  Google Scholar 

  108. Tamaddoni A, Nasseri E, Mohammadi E, Qujeq D, Zayeri F, Zand H et al (2019) A double-blind randomized controlled trial of curcumin for improvement in glycemic status, lipid profile and systemic inflammation in β-thalassemia major. J Herb Med 21:100324. https://doi.org/10.1016/j.hermed.2019.100324

    Article  Google Scholar 

  109. SilvaTAL MDC, Medeiros G, Medeiros R, de Souza AJ, Medeiros JA et al (2019) Influence of curcumin supplementation on metabolic and lipid parameters of people living with HIV/AIDS: a randomized controlled trial. BMC Complement Altern Med 19(1):202. https://doi.org/10.1186/s12906-019-2620-7

    Article  CAS  Google Scholar 

  110. Adibian M, Hodaei H, Nikpayam O, Sohrab G, Hekmatdoost A, Hedayati M (2019) The effects of curcumin supplementation on high-sensitivity C-reactive protein, serum adiponectin, and lipid profile in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. Phytother Res 33(5):1374–1383

    Article  CAS  PubMed  Google Scholar 

  111. Ferguson JJA, Stojanovski E, MacDonald-Wicks L, Garg ML (2018) Curcumin potentiates cholesterol-lowering effects of phytosterols in hypercholesterolaemic individuals. A randomised controlled trial. Metabolism 82:22–35

    Article  CAS  PubMed  Google Scholar 

  112. Panahi Y, Khalili N, Sahebi E, Namazi S, Reiner Ž, Majeed M et al (2017) Curcuminoids modify lipid profile in type 2 diabetes mellitus: a randomized controlled trial. Complement Ther Med 33:1–5

    Article  PubMed  Google Scholar 

  113. Panahi Y, Hosseini MS, Khalili N, Naimi E, Soflaei SS, Majeed M et al (2016) Effects of supplementation with curcumin on serum adipokine concentrations: a randomized controlled trial. Nutrition 32(10):1116–1122

    Article  CAS  PubMed  Google Scholar 

  114. Panahi Y, Khalili N, Hosseini MS, Abbasinazari M, Sahebkar A (2014) Lipid-modifying effects of adjunctive therapy with curcuminoids-piperine combination in patients with metabolic syndrome: results of a randomized controlled trial. Complement Ther Med 22(5):851–857

    Article  PubMed  Google Scholar 

  115. Yang YS, Su YF, Yang HW, Lee YH, Chou JI, Ueng KC (2014) Lipid-lowering effects of curcumin in patients with metabolic syndrome: a randomized, double-blind, placebo-controlled trial. Phytother Res 28(12):1770–1777

    Article  CAS  PubMed  Google Scholar 

  116. Mohammadi A, Sahebkar A, Iranshahi M, Amini M, Khojasteh R, Ghayour-Mobarhan M et al (2013) Effects of supplementation with curcuminoids on dyslipidemia in obese patients: a randomized crossover trial. Phytother Res 27(3):374–379

    Article  CAS  PubMed  Google Scholar 

  117. Panahi Y, Kianpour P, Mohtashami R, Jafari R, Simental-Mendía LE, Sahebkar A (2017) Efficacy and safety of phytosomal curcumin in non-alcoholic fatty liver disease: a randomized controlled trial. Drug Res (Stuttg) 67(4):244–251

    Article  CAS  Google Scholar 

  118. Rahmani S, Asgary S, Askari G, Keshvari M, Hatamipour M, Feizi A et al (2016) Treatment of non-alcoholic fatty liver disease with curcumin: a randomized placebo-controlled trial. Phytother Res 30(9):1540–1548

    Article  CAS  PubMed  Google Scholar 

  119. Panahi Y, Kianpour P, Mohtashami R, Jafari R, Simental-Mendía LE, Sahebkar A (2016) Curcumin lowers serum lipids and uric acid in subjects with nonalcoholic fatty liver disease: a randomized controlled trial. J Cardiovasc Pharmacol 68(3):223–229

    Article  CAS  PubMed  Google Scholar 

  120. Panahi Y, Khalili N, Sahebi E, Namazi S, Simental-Mendía LE, Majeed M et al (2018) Effects of curcuminoids plus piperine on glycemic, hepatic and inflammatory biomarkers in patients with type 2 diabetes mellitus: a randomized double-blind placebo-controlled trial. Drug Res (Stuttg) 68(7):403–409

    Article  CAS  Google Scholar 

  121. Mirhafez SR, Farimani AR, Dehhabe M, Bidkhori M, Hariri M, Ghouchani BF et al (2019) Effect of phytosomal curcumin on circulating levels of adiponectin and leptin in patients with non-alcoholic fatty liver disease: a randomized, double-blind, placebo-controlled clinical trial. J Gastrointestin Liver Dis 28:183–189

    Article  PubMed  Google Scholar 

  122. Mohammadi E, Tamaddoni A, Qujeq D, Nasseri E, Zayeri F, Zand H et al (2018) An investigation of the effects of curcumin on iron overload, hepcidin level, and liver function in β-thalassemia major patients: a double-blind randomized controlled clinical trial. Phytother Res 32(9):1828–1835

    Article  CAS  PubMed  Google Scholar 

  123. Nouri-Vaskeh M, Afshan H, Malek Mahdavi A, Alizadeh L, Fan X, Zarei M (2020) Curcumin ameliorates health-related quality of life in patients with liver cirrhosis: a randomized, double-blind placebo-controlled trial. Complement Ther Med 49:102351. https://doi.org/10.1016/j.ctim.2020.102351

    Article  PubMed  Google Scholar 

  124. Sabery Karimian M, Keshvari M, Ghayour-Mobarhan M, Salehizadeh L, Rahmani S, Behnam B et al (2020) Effects of curcuminoids on inflammatory status in patients with non-alcoholic fatty liver disease: an exploratory randomized controlled trial. Complement Ther Med 49:102322. https://doi.org/10.1016/j.ctim.2020.102322

    Article  Google Scholar 

  125. Nouri-Vaskeh M, Malek Mahdavi A, Afshan H, Alizadeh L, Zarei M (2020) Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial. Phytother Res 34(6):1446–1454

    Article  CAS  PubMed  Google Scholar 

  126. Chashmniam S, Mirhafez SR, Dehabeh M, Hariri M, Azimi Nezhad M, Nobakht MGBF (2019) A pilot study of the effect of phospholipid curcumin on serum metabolomic profile in patients with non-alcoholic fatty liver disease: a randomized, double-blind, placebo-controlled trial. Eur J Clin Nutr 73(9):1224–1235

    Article  CAS  PubMed  Google Scholar 

  127. Asadi S, Gholami MS, Siassi F, Qorbani M, Khamoshian K, Sotoudeh G (2019) Nano curcumin supplementation reduced the severity of diabetic sensorimotor polyneuropathy in patients with type 2 diabetes mellitus: a randomized double-blind placebo-controlled clinical trial. Complement Ther Med 43:253–260

    Article  PubMed  Google Scholar 

  128. Asadi S, Gholami MS, Siassi F, Qorbani M, Sotoudeh G (2019) Beneficial effects of nano-curcumin supplement on depression and anxiety in diabetic patients with peripheral neuropathy: a randomized, double-blind, placebo-controlled clinical trial. Phytother Res 34(4):896–903

    Article  PubMed  CAS  Google Scholar 

  129. Ahmadi M, Agah E, Nafissi S, Jaafari MR, Harirchian MH, Sarraf P et al (2018) Safety and efficacy of nanocurcumin as add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a pilot randomized clinical trial. Neurotherapeutics 15(2):430–438

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  130. Small GW, Siddarth P, Li Z, Miller KJ, Ercoli L, Emerson ND et al (2018) Memory and brain amyloid and tau effects of a bioavailable form of curcumin in non-demented adults: a double-blind, placebo-controlled 18-month trial. Am J Geriatr Psychiatry 26(3):266–277

    Article  PubMed  Google Scholar 

  131. Chico L, Ienco EC, Bisordi C, Lo Gerfo A, Petrozzi L, Petrucci A et al (2018) Amyotrophic lateral sclerosis and oxidative stress: a double-blind therapeutic trial after curcumin supplementation. CNS Neurol Disord Drug Targets 17(10):767–779

    Article  CAS  PubMed  Google Scholar 

  132. Fanaei H, Khayat S, Kasaeian A, Javadimehr M (2016) Effect of curcumin on serum brain-derived neurotrophic factor levels in women with premenstrual syndrome: a randomized, double-blind, placebo-controlled trial. Neuropeptides 56:25–31

    Article  CAS  PubMed  Google Scholar 

  133. Lopresti AL, Maes M, Meddens MJM, Maker GL, Arnoldussen E, Drummond PD (2015) Curcumin and major depression: a randomised, double-blind, placebo-controlled trial investigating the potential of peripheral biomarkers to predict treatment response and antidepressant mechanisms of change. Eur Neuropsychopharmacol 25(1):38–50

    Article  CAS  PubMed  Google Scholar 

  134. Esmaeili Vardanjani SA, Sehati Shafai F, Mohebi P, Deyhimi M, Delazar A, Ghojazadeh M et al (2012) Wound healing benefits of curcumin for perineal repair after episiotomy: results of an Iranian randomized controlled trial. Life Sci J 9(4):5536–5541

    Google Scholar 

  135. Manifar S, Obwaller A, Gharehgozloo A, Boorboor Shirazi Kordi HR, Akhondzadeh S (2012) Curcumin gel in the treatment of minor aphthous ulcer: a randomized, placebo- controlled trial. J Med Plants 11(41):40–45

    CAS  Google Scholar 

  136. Piyush P, Mahajan A, Singh K, Ghosh S, Gupta S (2019) Comparison of therapeutic response of lycopene and curcumin in oral submucous fibrosis: a randomized controlled trial. Oral Dis 25(1):73–79

    Article  PubMed  Google Scholar 

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Acknowledgements

The authors are grateful to Mashhad University of Medical Sciences (MUMS) for help and supports.

Conflict of Interest: None.

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Authors and Affiliations

  1. Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

    Maryam Akaberi

  2. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

  3. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

  4. Polish Mother’s Memorial, Hospital Research Institute (PMMHRI), Lodz, Poland

    Amirhossein Sahebkar

  5. Halal Research Center of IRI, FDA, Tehran, Iran

    Amirhossein Sahebkar

  6. Department of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

    Seyed Ahmad Emami

Authors
  1. Maryam Akaberi
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  2. Amirhossein Sahebkar
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  3. Seyed Ahmad Emami
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Correspondence to Amirhossein Sahebkar or Seyed Ahmad Emami .

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  1. University of Campinas, Sao Paulo, Brazil

    Paul C. Guest

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Akaberi, M., Sahebkar, A., Emami, S.A. (2021). Turmeric and Curcumin: From Traditional to Modern Medicine. In: Guest, P.C. (eds) Studies on Biomarkers and New Targets in Aging Research in Iran. Advances in Experimental Medicine and Biology(), vol 1291. Springer, Cham. https://doi.org/10.1007/978-3-030-56153-6_2

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