Infectious Bronchitis Virus Envelope Protein Targeting: Implications for Virus Assembly

Abstract

Coronaviruses acquire their membrane envelope by budding into the lumen of Golgi and pre-Golgi compartments. After budding, virions are thought to move in vesicles through the secretory pathway, and exit the cell when these vesicles fuse with the plasma membrane (Holmes et al., 1981, Tooze et al., 1987). The specific compartment into which coronaviruses bud is the cis-Golgi network (CGN), also known as the endoplasmic reticulum Golgi intermediate compartment (Krijnse Locker et al., 1994). Just as enveloped viruses that bud from the plasma membrane must direct the accumulation of their envelope proteins at the cell surface, coronaviruses must localize their envelope proteins to the membranes of the CGN.

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