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Homo- and Heterodimerization in Transcriptional Regulation

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Protein Dimerization and Oligomerization in Biology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 747))

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Abstract

Eukaryotic transcription factors bind DNA and typically serve to localize large multiprotein complexes to particular genes to up- or downregulate transcription, thereby coordinating cellular responses to a variety of signals. Different combinations of transcription factors within DNA-binding multiprotein complexes allow individual proteins to partake in multiple different regulatory pathways. Many transcription factors can form homo- and heterodimers (or oligomers) with different partners, thus modulating DNA-binding specificity and affinity and/or the recruitment of different binding partners. This chapter reviews several of the mechanisms by which the homo- and heterodimerization of transcription factors contributes to transcriptional regulation.

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Authors and Affiliations

  1. School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia

    Alister P. W. Funnell & Merlin Crossley

  2. School of Molecular Bioscience, University of Sydney, Sydney, New South Wales, Australia

    Alister P. W. Funnell & Merlin Crossley

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  1. Alister P. W. Funnell
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    Jacqueline M. Matthews PhD

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Funnell, A.P.W., Crossley, M. (2012). Homo- and Heterodimerization in Transcriptional Regulation. In: Matthews, J.M. (eds) Protein Dimerization and Oligomerization in Biology. Advances in Experimental Medicine and Biology, vol 747. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3229-6_7

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