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FGF19 and Cancer

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Endocrine FGFs and Klothos

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 728))

Abstract

Fibroblast growth factors (FGFs) and their cognate receptors, FGF receptors (FGFRs), play critical roles in a variety of normal developmental and physiological processes. Numerous reports support a role for deregulation of FGF-FGFR signaling, whether it is at the ligand and/or receptor level, in tumor development and progression. The FGF19-FGFR4 signaling axis has been implicated in the pathogenesis of several cancers, including hepatocellular carcinomas in mice and potentially in humans. This chapter focuses on recent progress in the understanding of the molecular mechanisms of FGF19 action and its potential involvement in cancer.

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Author information

Author notes

  1. Luc R. Desnoyers

    Present address: Oncology Biomarker Development/Pharmacodynamic Biomarkers, Genentech, Inc., South San Francisco, California, USA

Authors and Affiliations

  1. Oncology Biomarker Development/Pharmacodynamic Biomarkers, Genentech, Inc., South San Francisco, California, USA

    Benjamin C. Lin

Authors
  1. Benjamin C. Lin
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  2. Luc R. Desnoyers
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Editor information

Editors and Affiliations

  1. Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA

    Makoto Kuro-o MD, PhD

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Lin, B.C., Desnoyers, L.R. (2012). FGF19 and Cancer. In: Kuro-o, M. (eds) Endocrine FGFs and Klothos. Advances in Experimental Medicine and Biology, vol 728. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0887-1_12

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