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Mesenchymal-Epithelial Interactions in the Growth and Development of the Prostate

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Urologic Oncology

Part of the book series: Cancer Treatment and Research ((CTAR,volume 46))

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Abstract

The ductal networks within the prostate originate from solid epithelial outgrowths (prostatic buds) that emerge from the endodermal urogenital sinus (UGS) immediately below the developing bladder and grow into the surroundings mesenchyme (loose undifferentiated fetal connective tissue). In the human fetus, the first epithelial buds arise from the prostatic urethra around the 10th week of gestation [1–5]. The ducts grow rapidly in length, arborize, and canalize. By 13 weeks there are approximately 70 primary ducts, some of which exhibit secretory cytodifferentiation [1, 3]. The prostatic buds arise from different parts of the prostatic urethra in five separate groups in humans [1]. This observation led Lowsley to originally propose the concept of prostatic lobes. In mouse fetuses, prostatic buds appear on the 17th day of gestation (vaginal plug = day zero), while in fetal rats they appear 1 to 2 days later [6]. In the mouse one to three main ducts per side emerge from the ventral aspect of the UGS, while about 20 to 25 ducts per side emerge from the dorsolateral aspect of the UGS [7]. These two groups of ducts will form the ventral and dorsolateral lobes, respectively. The coagulating gland or anterior prostate is derived from two large buds per side, which grow cranially into the mesenchyme associated with the seminal vesicle [8]. In rats and mice, branching of the prostatic ducts primarily occurs postnatally. Branching patterns are unique for each lobe of the prostate.

Supported by NIH grants HD 17491 and HD 21919

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References

  1. Lowsley OS: The development of the human prostate gland with reference to the development of other structures at the neck of the urinary bladder. Am J Anat 13: 299–349, 1912.

    Article  Google Scholar 

  2. Johnson FP: The later development of the urethra in the male. J Urol 4: 447–501, 1920.

    Google Scholar 

  3. Kellokumpu-Lehtinen P: The histochemical localizations of acid phosphatase in human fetal urethral and prostatic epithelium. Invest Urol 17: 435–440, 1980.

    PubMed  CAS  Google Scholar 

  4. Kellokumpu-Lehtinen P: Development of sexual dimorphism in human urogenital sinus complex. Biol Neonate 48: 157–167, 1985.

    Article  PubMed  CAS  Google Scholar 

  5. Kellokumpu-Lehtinen P, Santti R, Pelliniemi LJ: Correlation of early cytodifferentiation of the human fetal prostate and Leydig cells. Anat Rec 196: 263–273, 1980.

    Article  PubMed  CAS  Google Scholar 

  6. Price D, Ortiz E: The role of fetal androgens in sex differentiation in mammals. In: Organogenesis, RL DeHaan and H Ursprung (eds). Holt, Rinehart and Winston, New York, 1965, pp. 629–652.

    Google Scholar 

  7. Sugimura Y, Cunha GR, Donjacour AA: Morphogenesis of ductal networks in the mouse prostate. Biol Reprod 34: 961–971, 1986.

    Article  PubMed  CAS  Google Scholar 

  8. Lung B, Cunha GR: Development of seminal vesicles and coagulating glands in neonatal mice. 1. The morphogenetic effects of various hormonal conditions. Anat Rec 199: 73–88, 1981.

    Article  PubMed  CAS  Google Scholar 

  9. Sugimura Y, Cunha GR, Donjacour AA, Bigsby RM, Brody JR: Whole-mount autoradiography study of DNA synthetic activity during postnatal development and androgen-induced regeneration in the mouse prostate. Biol Reproduct 34: 985–995, 1986.

    Article  CAS  Google Scholar 

  10. Zondek T, Zondek LH: The fetal and neonatal prostate. In: Normal and Abnormal Growth of the Prostate, M Goland (ed). CC Thomas, Springfield, 1975, pp. 5–27.

    Google Scholar 

  11. Berry SJ, Coffey DS, Walsh PC, Ewing LL: The development of human benign prostatic hyperplasia with age. J Urol 132: 474–479, 1984.

    PubMed  CAS  Google Scholar 

  12. Haffen K, Kedinger M, Simon-Assmann P: Mesenchyme-dependent differentiation of epithelial progenitor cells in the gut. J Ped Gastro Nutri 6: 14–23, 1987.

    Article  CAS  Google Scholar 

  13. Kedinger M, Haffen K, Simon-Assmann P: Control mechanisms in the ontogenesis of villus cells. In: Molecular and Cellular Basis of Digestion, P Desnuelle, H Sjöström, O Noren (eds). Elsevier, New York, 1986, pp. 323–367.

    Google Scholar 

  14. Yasugi S, Mizuno T: Differentiation of the digestive tract epithelium under the influence of the heterologous mesenchyme of the digestive tract in the bird embyros. Develop Growth and Differ 20(3): 261–267, 1978.

    Article  Google Scholar 

  15. Sengel P: Morphogenesis of Skin. Cambridge University Press, New York, 1976, pp. 1–227.

    Google Scholar 

  16. Saxén L, Ekblom P, Thesleff I: Cell-matrix interaction in organogenesis. In: New Trends in Basement Membrane Research, K Kuehn, H Schoene, R Timpl (eds). Raven Press, New York, 1982, pp. 257–264.

    Google Scholar 

  17. Weniger J-P, Zeis A: Sur la secertion precoce de testosterone par le testicule embryonnaire de souris. CR Acad Sc Paris 275: 1431–1433, 1972.

    CAS  Google Scholar 

  18. Resko JA: Androgen secretion by the fetal and neonatal rhesus monkey. Endrinol 87: 680–687, 1978.

    Google Scholar 

  19. Pointis G, Latreille MT, Cedard L: Gonado-pituitary relationships in the fetal mouse at various times during sexual differentiation. J. Endocrinol 86: 483–488, 1980.

    Article  PubMed  CAS  Google Scholar 

  20. Siiteri PK, Wilson JD: Testosterone formation and metabolism during male sexual differentiation in the human embryo. J Clin Endocrinol Metab 38: 113–125, 1974.

    Article  PubMed  CAS  Google Scholar 

  21. Winter JSD, Faiman C, Reyes F: Sexual endocrinology of fetal and perinatal life. In: Mechanisms of Sex Differentiation in Animals and Man, CR Austin, RG Edwards (eds). Academic Press, New York, 1981, pp. 205–254.

    Google Scholar 

  22. Jost A: Problems of fetal endocrinology: The gonadal and hypophyseal hormones. Recent Prog Horm Res 8: 379–418, 1953.

    Google Scholar 

  23. Raynaud A, Frilley M: Destruction de cerveau des embryos de souris au trezieme jour de la gestation, par irradiation au moyen des rayons X. Compt Rend Soc Biol 141: 658–662, 1947.

    CAS  Google Scholar 

  24. Neumann F, Elger W, Steinbeck H: Antiandrogens and reproductive development. Philos Trans R Soc Lond [Biol] 259: 179–184, 1970.

    Article  CAS  Google Scholar 

  25. Neumann F, Graf K-J, Elger W: Hormone-induced disturbances in sexual differentiation. Adv in the Biosciences 13: 71–101, 1974.

    CAS  Google Scholar 

  26. Elger W, Graf K-J, Steinbeck H, Neumann F: Hormonal control of sexual development. Adv in the Biosciences 13: 41–69, 1974.

    CAS  Google Scholar 

  27. Burns RK: Role of hormones in the differentiation of sex. In: Sex and Internal Secretions, WC Young (ed). Williams and Wilkins, Baltimore, 1961, pp. 76–158.

    Google Scholar 

  28. Greene RR: Hormonal factors in sex inversion: The effects of sex hormones on embryonic sexual structures of the rat. Biol Symp 9: 105–123, 1940.

    Google Scholar 

  29. Greene RR, Burrill MW, Ivy AC: The effects of estrogens on the antenatal sexual development of the rat. Am J Anat 67: 305–345, 1939.

    Article  Google Scholar 

  30. Cunha GR: The role of androgens in the epithelio-mesenchymal interactions involved in prostatic morphogenesis in embryonic mice. Anat Rec 175: 87–96, 1973.

    Article  PubMed  CAS  Google Scholar 

  31. Lasnitzki I, Mizuno T: Induction of rat prostate gland by androgens in organ culture. J. Endocrinol 74: 47–55, 1977.

    Article  PubMed  CAS  Google Scholar 

  32. Takeda I, Lasnitzki I, Mizuno T: Analysis of prostatic bud induction by brief androgen treatment in the fetal rat urogenital sinus. J Endocrinol 110: 467–470, 1986.

    Article  PubMed  CAS  Google Scholar 

  33. Price D: Normal development of the prostate and seminal vesicles of the rat with a study of experimental postnatal modifications. Am J Anat 60: 79–127, 1936.

    Article  Google Scholar 

  34. Donjacour AA, Cunha GR: The effect of andrgen deprivation on branching morphogenesis in the mouse prostate. Develop Biol, in press, 1988.

    Google Scholar 

  35. Berry S, Isaacs JT: Comparative aspects of prostatic growth and androgen metabolism with aging in the rat versus the dog. Endocrinol 114: 511–518, 1984.

    Article  Google Scholar 

  36. Price D, Ortiz E: The relation of age to reactivity in the reproductive system of the rat. Endocrinol 34: 215–239, 1944.

    Article  Google Scholar 

  37. Lasnitzki I, Franklin HR: The influence of serum on uptake, conversion and action of testesterone in rat prostate glands in organ culture. J Endocrinol 54: 333–342, 1972.

    Article  PubMed  CAS  Google Scholar 

  38. Wilson JD, Lasnitzki I: Dihydrostestosterone formation in fetal tissues of the rabbit and rat. Endocrinol 89: 659–668, 1971.

    Article  CAS  Google Scholar 

  39. Wilson JD, Griffin JE, Leshin M, George FW: Role of gonadal hormones in development of the sexual phenotypes. Human Genetics 58: 78–84, 1981.

    Article  PubMed  CAS  Google Scholar 

  40. Imperato-McGinley J, Binienda Z, Arthur A, Minenberg DT, Vaughan ED, Quimby FW: The development of a male psuedohermaphroditic rat using an inhibitor of the enzyme 5a-reductase. Endocrinol 116: 807–812, 1985.

    Article  CAS  Google Scholar 

  41. Imperato-McGinley J: 5a-reductase deficiency in man. Prog Cane Res and Ther 31: 491–496, 1984.

    Google Scholar 

  42. Imperato-McGinley J, Guerrero L, Gautier T, Peterson RE: Steroid 5a-reductase deficiency in man: An inherited form of psuedohermaphroditism. Science 186: 1213–1215, 1974.

    Article  PubMed  CAS  Google Scholar 

  43. Imperato-McGinley J, Peterson RE, Gautier T: Primary and secondary 5a-reductase deficiency. In: Sexual Differentiation: Basic and Clinical Aspects, M Serio, M Zanisi, M Motta, L Martini (eds). Raven Press, New York, 1984, pp. 233–245.

    Google Scholar 

  44. Shannon JM, Cunha GR, Vanderslice KD: Autoradiographic localization of androgen receptors in the developing urogenital tract and mammary gland. Anat Rec 199: 232, 1981.

    Google Scholar 

  45. Shannon JM, Cunha GR: Autoradiographic localization of androgen binding in the developing mouse prostate. Prostate 4: 367–373, 1983.

    Article  PubMed  CAS  Google Scholar 

  46. Takeda H, Miguno T, Lasnitzki I: Autoradiographic studies of androgen-binding sites in the rat urogenital sinus and postnatal prostate. J Endocrinol 104: 87–92, 1985.

    Article  PubMed  CAS  Google Scholar 

  47. Wasner G, Hennermann I, Kratochwil K: Ontogeny of mesenchymal androgen receptors in the embryonic mouse mammary gland. Endocrinol 113: 1771–1780, 1983.

    Article  CAS  Google Scholar 

  48. Ohno S: Major Sex Determining Genes. Springer-Verlag, New York, 1979, pp. 1–140.

    Google Scholar 

  49. Griffin JE, Wilson JD: Disorders of androgen receptor function. Ann NY Acad Sci 43: 61–71, 1984.

    Article  Google Scholar 

  50. Wilson JD, Griffin JE, George FW, Leshin M: Recent studies on the endocrine control of male phenotypic development. In: Sexual Differentiation: Basic and Clinical Aspects, M Serio, M Zanisi, M Motta, L Martini (eds). Raven Press, New York, 1984, pp. 223–232.

    Google Scholar 

  51. Lyon MF, Cattanach BM, Charlton HM: Genes affecting sex differentiation in mammals. In: Mechanisms of Sex Differentiation in Animals and Man, CR Austin, RG Edwards (eds). Academic Press, New York, 1981, pp. 327–386.

    Google Scholar 

  52. Bardin CW, Bullock LP, Sherins RJ, Mowszowicz I, Blackburn: Androgen metabolism and mechanism of action in male pseudohermaphroditism: A study of testicular feminization. Res Prog Hormone Res 29: 65–109, 1973.

    CAS  Google Scholar 

  53. Forsberg J-G, Jacobsohn D, Norgren A: Modifications of reproductive organs in male rats influenced prenatally or pre- and postnatally by an ‘antiandrogenic’ steroid (Cyproterone). Z Anat Entwicks Gesch 126: 175–186, 1968.

    Article  Google Scholar 

  54. Cunha GR: Epithelio-mesenchymal interactions in primordial gland structures which become responsive to androgenic stimulation. Anat Rec 172: 179–196, 1972.

    Article  PubMed  CAS  Google Scholar 

  55. Cunha GR: Tissue interactions between epithelium and mesenchyme of urogenital and integumental origin. Anat Rec 172: 529–542, 1972.

    Article  PubMed  CAS  Google Scholar 

  56. Cunha GR: Support of normal salivary gland morphogenesis by mesenchyme derived from accessory sexual glands of embryonic mice. Anat Rec 173: 205–212, 1972.

    Article  PubMed  CAS  Google Scholar 

  57. Norman JT, Cunha GR, Sugimura Y: The induction of new ductal growth in adult prostatic epithelium in response to an embryonic prostatic inductor. Prostate 8: 209–220, 1986.

    Article  PubMed  CAS  Google Scholar 

  58. Neubauer BL, Best KL, Hoover DM, Slisz ML, Van Frank RM, Goode RL: Mesenchymal-epithelial interactions as factors influencing male accessory sex organ growth. Fed Proc 49: 2618, 1986.

    Google Scholar 

  59. Cunha GR, Lung B, Reese BA: Glandular epithelial induction by embryonic mesenchyme in adult bladder epithelium of balb/c mice. Invest Urol 17: 302–304, 1980.

    PubMed  CAS  Google Scholar 

  60. Cunha GR: Fujii H, Neubauer BL, Shannon M, Sawyer LM, Reese BA: Epithelial-mesenchymal interactions in prostatic development. I. Morphological observations of prostatic induction by urogenital sinus mesenchyme in epithelium of the adult rodent urinary bladder. J Cell Biol 96: 1662–1670, 1983.

    Article  PubMed  CAS  Google Scholar 

  61. Cunha GR: Age-dependent loss of sensitivity of female urogenital sinus to andogenic conditions as a function of the epithelial-stormal interaction in mice. Endocrinol 95: 665–673, 1975.

    Article  Google Scholar 

  62. Felix W:·The development of the urogenital organs. In: Manual of Human Embryology, R Kibel, FP Mall (eds). Lippincott, Philadelphia, 1912, pp. 869–972.

    Google Scholar 

  63. Cunha GR: Development of the male urogenital tract. In: Urologic Endocrinology, J Rajfer (ed). WB Saunders, Philadelphia, 1986, pp. 6–16.

    Google Scholar 

  64. Cunha GR, Lung B: The possible influences of temporal factors in androgenic responsiveness of urogenital tissue recombinants from wild-type and androgen-insensitive (Tfm) mice. J Exp Zool 205: 343–342, 1978.

    Article  Google Scholar 

  65. Cunha GR, Chung LWK, Shannon JM, Reese BA: Stromal-epithelial interactions in sex differentiation. Biol Reprod 22: 19–43, 1980.

    Article  PubMed  CAS  Google Scholar 

  66. Neubauer BL, Chung LWK, McCormick K, Taguchi, Thompson TC, Cunha GR: Epithelial-mesenchymal interactions in prostatic development. II. Biochemical observations of prostatic induction by urogenital sinus mesenchyme in epithelium of the adult rodent urinary bladder. J Cell Biol 96: 1671–1676, 1983.

    Article  PubMed  CAS  Google Scholar 

  67. Cunha GR: Epithelial-stromal interactions in development of the urogenital tract. Int Rev Cytol 47: 137–194, 1976.

    Article  PubMed  CAS  Google Scholar 

  68. Cunha GR, Sekkingstad M, Meloy BA: Heterospecifi induction of prostatic development in tissue recombinants prepared with mouse, rat, rabbit, and human tissues. Differentiation 24: 174–180, 1983.

    Article  PubMed  CAS  Google Scholar 

  69. Jost A: Modalities in the action of androgens on the foetus. Res in Steroids 3: 207–220, 1968.

    Google Scholar 

  70. Isaacs JT: Antagonistic effect of androgen on prostatic cell death. Prostate 5: 545–557, 1984.

    Article  PubMed  CAS  Google Scholar 

  71. Lee C: Physiology of castration-induced regression in rat prostate. In: The Prostatic Cell: Structure and Function, Part A, JP Karr, AA Sandberg, GP Murphy (eds). AR Liss, New York, 1981, pp. 145–159.

    Google Scholar 

  72. Tuohimaa P: Control of cell proliferation in male accessory sex glands. In: Male Accessory Sex Glands, E Spring-Mills, ESE Hafez (eds). Elsevier/North Holland, New York, 1980, pp. 131–153.

    Google Scholar 

  73. Chung LWK, Cunha GR: Stromal-epithelial interactions. II. Regulation of prostatic growth by embryonic urogenital sinus mesenchyme. Prostate 4: 503–511, 1983.

    Article  PubMed  CAS  Google Scholar 

  74. DeKlerk DP, Coffey DS: Quantitative determination of prostatic epithelial and stromal hyperplasia by a new technique: Biomorphometrics. Invest Urol 16: 240–245, 1978.

    PubMed  CAS  Google Scholar 

  75. Sugimura Y, Cunha GR, Donjacour AA: Morphological and histological study of castration-induced degeneration and androgen-induced regeneration in the mouse prostate. Biol of Reprod 34: 973–983, 1986.

    Article  CAS  Google Scholar 

  76. English HF, Drago JR, Santen RJ: Cellular response to androgen depletion and repletion in the rat ventral prostate: Autoradiography and morphometric analysis. Prostate 7: 41–51, 1985.

    Article  PubMed  CAS  Google Scholar 

  77. Bernfield MR, Cohn RH, Banerjee SD: Glycosaminoglycans and epithelial organ formation. Am Zool 13: 1067–1083, 1973.

    CAS  Google Scholar 

  78. Wessells NK: Mammalian lung development: Interactions in formation and morphogenesis of tracheal buds. J Exp Zool 175: 455–466, 1970.

    Article  PubMed  CAS  Google Scholar 

  79. Alescio T, Cassini A: Induction in vitro of tracheal buds by pulmonary mesenchyme grafted on tracheal epithelium. J Exp Zool 150: 83–94, 1962.

    Article  PubMed  CAS  Google Scholar 

  80. Kratochwil K: Organ specificity in mesenchymal induction demonstrated in the embryonic development of the mammary gland of the mouse. Develop Biol 20: 46–71, 1969.

    Article  PubMed  CAS  Google Scholar 

  81. Cooke PS, Young PF, Cunha GR: Androgen dependence of growth and epithelial morphogenesis in neonatal mouse bulbourethral glands. Endocrinol 121: 2153–2160, 1987.

    Article  CAS  Google Scholar 

  82. Sakakura T, Nishizuka Y, Dawe CJ: Mesenchyme-dependent morphogenesis and epithelium-specific cytodifferentiation in mouse mammary gland. Science 194: 1439–1441, 1976.

    Article  PubMed  CAS  Google Scholar 

  83. DeKlerk DP, Lombard CJ: Stromal and epithelial growth of the prostate during puberty. Prostate 9: 191–198, 1986.

    Article  CAS  Google Scholar 

  84. Bruchovsky N, Lesser B, van Doorn EV, Craven S: Hormonal effects on cell proliferation in rat prostate. Vitam Horm 33: 61–102, 1975.

    Article  PubMed  CAS  Google Scholar 

  85. Chung LWK, Matsuura J, Runner MN: Tissue interactions and prostatic growth. Biol of Reprod 31: 155–163, 1984.

    CAS  Google Scholar 

  86. Thompson TC, Chung LWK: Regulation of overgrowth and expression of prostatic binding protein in rat chimeric prostate gland. Endocrinol 118: 2437–2444, 1986.

    Article  CAS  Google Scholar 

  87. DeOme KB, Faulkin LJ, Bern HA, Blair PB: Development of mammary tumors from hymperplastic alveolar nodules transplanted into gland-free mammary fat pads of female C3H mice. Cancer Res 19: 515, 1959.

    PubMed  CAS  Google Scholar 

  88. Daniel CW, Young LJ: Influence of cell division on an aging process. Life span of mouse mammary epithelium during serial propagation in vivo. Exp Cell Res 65: 27–32, 1971.

    Article  PubMed  CAS  Google Scholar 

  89. Daniel CW, DeOme KB, Young JT, Blair PB, Faulkin LJ: The in vivo lift span of normal and preneoplastic mouse mammary glands: A serial transplantation study. PNAS 61: 53–60, 1968.

    Article  PubMed  CAS  Google Scholar 

  90. Sakakura T, Nishizuka T, Dawe CJ: Capacity of mammary fat pads of adult C3h/HeMs mice to interact morphogenetically with fetal mammary epithelium. J Natl Cancer Inst 63: 733–736, 1979.

    PubMed  CAS  Google Scholar 

  91. Sakakura T, Sakagami Y, Nishizuka Y: Persistence of responsiveness of adult mouse mammary gland to induction by embryonic mesenchyme. Develop Biol 72: 201–210, 1979.

    Article  PubMed  CAS  Google Scholar 

  92. Jost A: Gonadal hormones in the sex differentiation of the mammalian fetus. In: Organogenesis, RL DeHaan and H Urpsrung (eds). Holt, Rinehart and Winston, New York, 1965, pp. 611–628.

    Google Scholar 

  93. Lasnitzki I, Mizuno T: Prostatic induction and interaction of epithelium and mesenchyme from normal wild-type and androgen-insensitive mice with testicular feminization. J Endocrinol 85: 423–428, 1980.

    Article  PubMed  CAS  Google Scholar 

  94. Kratochwil K, Schwartz P: Tissue interaction in androgen response of the embryonic mammary rudiment of mouse: Identification of target tissue of testosterone. PNAS USA 73: 4041–4044, 1976.

    Article  PubMed  CAS  Google Scholar 

  95. Drews U, Drews U: Regression of mouse mammary gland anlagen in recombinants of Tfm and wild-type tissues: Testosterone acts via the mesenchyme. Cell 10: 401–404, 1977.

    Article  PubMed  CAS  Google Scholar 

  96. Shannon JM, Cunha GR: Characterization of androgen binding and deoxyribonucleic acid synthesis in prostate-like structures induced in testicular feminized (Tfm/Y) mice. Biol Reprod 31: 175–183, 1984.

    Article  PubMed  CAS  Google Scholar 

  97. Cunha GR, Chung LWK, Shannon JM, Taguchi O, Fujii H: Hormone-induced morphogenesis and growth: Role of mesenchymal-epithelial interactions. Rec Prog Horm Res 39: 559–598, 1983.

    PubMed  CAS  Google Scholar 

  98. Sugimura Y, Cunha GR, Bigsby RM: Androgenic induction of deoxyribonucleic acid synthesis in prostate-like glands induced in the urothelium of testicular feminized (Tfm/y) mice. Prostate 9: 217–225, 1986.

    Article  PubMed  CAS  Google Scholar 

  99. Cunha GR, Reese BA, Sekkingstad M: Induction of nuclear androgen-binding sites in epithelium of the embryonic urinary bladder by mesenchyme of the urogenital sinus of embryonic mice. Endocrinol 107: 1767–1770, 1980.

    Article  CAS  Google Scholar 

  100. Cunha GR, Chung LWK: Stromal-epithelial interactions: Induction of prostatic phenotype in urothelium of testicular feminized (Tfm/y) mice. J Steroid Biochem 14: 1317–3121, 1981.

    Article  PubMed  CAS  Google Scholar 

  101. Franks LM, Barton AA: The effects of testosterone in the ultrastructure of the mouse prostate in vivo and in organ cultures. Exp Cell Res 19: 35–50, 1960.

    Article  PubMed  CAS  Google Scholar 

  102. Franks LM, Riddle PN, Carbonell AW, Gey GO: A comparative study of the ultrastructure and lack of growth capacity of adult human prostate epithelium mechanically separated from its stroma. J Pathol 100: 113–119, 1970.

    Article  PubMed  CAS  Google Scholar 

  103. Webber MM: Growth and maintenance of normal prostatic epithelium in vitro — a human cell model. Prog Clin Biol Res 37: 181–216, 1980.

    PubMed  CAS  Google Scholar 

  104. McKeehan WL, Adams PS, Rosser MP: Direct mitogenic effects of insulin, epidermal growth factor, glucocorticoid, cholera toxin, unknown pituitary factors and possibly prolactin, but not androgen, on normal rat prostate epithelial cells in serum-free, primary cell culture. Cancer Res 44: 1998–2010, 1984.

    PubMed  CAS  Google Scholar 

  105. Peehl DM, Stamey TA: Serum-free growth of adult human prostatic epithelial cells. In Vitro Cellular & Develop Biol 22: 82–90, 1986.

    Article  CAS  Google Scholar 

  106. Buchanan LJ, Riches AC: Proliferative responses of rat ventral prostate: Effects of variations in organ culture media and methodology. Prostate 8: 63–74, 1986.

    Article  PubMed  CAS  Google Scholar 

  107. Santti RS, Johansson R: Some biochemical effects of insulin and steroid hormones on the rat prostate in organ culture. Exp Cell Res 77: 111–120, 1973.

    Article  PubMed  CAS  Google Scholar 

  108. Sandberg AA, Kadohama N: (Regulation of prostatic growth in organ culture. Prog Clin Biol Res 37: 9–29, 1980.

    PubMed  CAS  Google Scholar 

  109. Johansson R, Niemi M: DNA and protein synthesis of prostatic cultures in relation to histological response under the influence of testosterone and its metabolites. Acta Endocrinol 78: 766–780, 1975.

    PubMed  CAS  Google Scholar 

  110. Lasnitzki I: The prostate in organ culture. In: Brandes D (ed). Male Accessory Sex Organs: Structure and Function. Academic Press, New York, pp. 348–382.

    Google Scholar 

  111. Lieber MM, Veneziale CM: Cell and organ culture of male accessory sex organs. Adv Sex Hormone Res 4: 73–118, 1980.

    Google Scholar 

  112. Cooke PS, Fujii DK, Cunha GR: Vaginal and uterine stroma maintain their inductive properties following primary culture. In Vitro Cellular & Develop Biol 23: 159–166, 1987.

    Article  CAS  Google Scholar 

  113. Fujii H, Cunha GR, Norman JT: The induction of adenocarcinomatous differentiation in neoplastic bladder epithelium by an embryonic prostatic inductor. J Urol 128: 858–861, 1982.

    PubMed  CAS  Google Scholar 

  114. Sakakura T, Sakagami Y, Nishizuka Y: Acceleration of mammary cancer development by grafting of fetal mammary mesenchymes in C3H mice. Gann 70: 459–466, 1979.

    PubMed  CAS  Google Scholar 

  115. Sakakura T, Sakagami Y, Nishizuka Y: Accelerated mammary cancer development by fetal salivary mesenchyme isografted to adult mouse mammary epithelium. J Nat Cancer Inst 66: 953–959, 1981.

    PubMed  CAS  Google Scholar 

  116. De Cosse JJ, Gossens CL, Kuzma JF, Unsworth BR: Embryonic inductive tissues that cause histological differentiation of murine mammary carcinoma in vitro. J Natl Caner Inst 54: 913–921, 1975.

    Google Scholar 

  117. DeCosse J, Gossens CL, Kuzma JF: Breast cancer: Induction of differentiation by embryonic tissue. Science 181: 1057–1058, 1973.

    Article  PubMed  CAS  Google Scholar 

  118. Cooper M, Pinkus H: Intrauterine transplantation of rat basal cell carcinoma: A model for reconversion of malignant of benign growth. Cancer Res 37: 2544–2552, 1977.

    PubMed  CAS  Google Scholar 

  119. Hodges GM, Hicks RM, Spacey GD: Epithelial-stromal interactions in normal and chemical carcinogen-treated adult bladder. Cancer Res 37: 3720–3730, 1977.

    PubMed  CAS  Google Scholar 

  120. Mackenzie JC, Dabelsteen E, Roed-Peterson B: A method for studying epithelial-mesenchymal interactions in human oral mucosal lesions. Scand J Dent Res 87: 234–243, 1979.

    PubMed  CAS  Google Scholar 

  121. McNeal JE: The prostate prostate gland — morphology and pathiobiology. Monographs in Urology 4: 3–37, 1983.

    Google Scholar 

  122. McNeal JE: Evolution of benign prostatic enlargement. Invest Urology 15: 340–345, 1978.

    CAS  Google Scholar 

  123. Bartsch G, Frick J, Ruegg I, Bucher M, Holliger O, Oberholzer M, Rohr HP: Electron microscopic stereological analysis of the normal human prostate and of benign prostatic hyperplasia. J Urol 122: 481–486, 1979.

    PubMed  CAS  Google Scholar 

  124. Bartsch G, Rohr HP: Comparative light and electron microscopic study of the human, dog and rat prostate. Urol Int 35: 91–104, 1980.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Gerald R. Cunha
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  2. Annemarie A. Donjacour
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  1. The Jewish Hospital of St. Louis, Washington University School of Medicine, 216 South Kingshighway Boulevard, St. Louis, Missouri, 63178, USA

    Herbert Lepor M.D.  & Timothy L. Ratliff Ph.D.  & 

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© 1989 Kluwer Academic Publishers, Boston

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Cunha, G.R., Donjacour, A.A. (1989). Mesenchymal-Epithelial Interactions in the Growth and Development of the Prostate. In: Lepor, H., Ratliff, T.L. (eds) Urologic Oncology. Cancer Treatment and Research, vol 46. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1595-7_9

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  • DOI: https://doi.org/10.1007/978-1-4613-1595-7_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8883-1

  • Online ISBN: 978-1-4613-1595-7

  • eBook Packages: Springer Book Archive

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