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Impact of Differential Glycosylation on IgG Activity

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Crossroads between Innate and Adaptive Immunity III

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 780))

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Abstract

Immunoglobulin G (IgG) molecules are glycoproteins with dual functionality. While participating in the destruction of virally infected cells or healthy tissues during autoimmune disease, IgG antibodies are also used as a therapeutic agent to suppress IgG-triggered autoimmune disease and inflammation. Research of recent years has put the IgG-associated sugar moiety in the spotlight for regulating these opposing activities. This review will focus on how certain IgG glycovariants impact different IgG-dependent effector functions and how this knowledge might be used to further improve the therapeutic effectiveness of this class of molecules.

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Acknowledgements

This work was supported by grants from the German Research Foundation (SFB 643, FOR832, GK1660, SPP1468) and the Bavarian Genome Research Network (BayGene) to F.N. We apologize to all colleagues whose important work could not be cited directly due to limitation in space. These references can be found in the review articles referred to in this manuscript.

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  1. Department of Biology, Institute of Genetics, University of Erlangen-Nuremberg, Staudtstr. 5, 91058, Erlangen, Germany

    Falk Nimmerjahn

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  1. Anja Lux
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  2. Falk Nimmerjahn
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Correspondence to Falk Nimmerjahn .

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Editors and Affiliations

  1. Emory Vaccine Center &, Yerkes National Primate Research Center, Emory University, Gatewood Rd. 954, Atlanta, 30329, Georgia, USA

    Bali Pulendran

  2. College of Medicine, Department Microbiology & Immunology, Drexel University, Queen Lane 2900, Philadelphia, 19129, Pennsylvania, USA

    Peter D. Katsikis

  3. , Laboratory of Cellular Immunology, La Jolla Institute for Allergy and Immun, Athena Circle 9420, La Jolla, 92037, USA

    Stephen P. Schoenberger

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Lux, A., Nimmerjahn, F. (2011). Impact of Differential Glycosylation on IgG Activity. In: Pulendran, B., Katsikis, P., Schoenberger, S. (eds) Crossroads between Innate and Adaptive Immunity III. Advances in Experimental Medicine and Biology, vol 780. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-5632-3_10

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