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mRNA Cancer Vaccines—Messages that Prevail

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Cancer Vaccines

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 405))

Abstract

During the last decade, mRNA became increasingly recognized as a versatile tool for the development of new innovative therapeutics. Especially for vaccine development, mRNA is of outstanding interest and numerous clinical trials have been initiated. Strikingly, all of these studies have proven that large-scale GMP production of mRNA is feasible and concordantly report a favorable safety profile of mRNA vaccines. Induction of T-cell immunity is a multi-faceted process comprising antigen acquisition, antigen processing and presentation, as well as immune stimulation. The effectiveness of mRNA vaccines is critically dependent on making the antigen(s) of interest available to professional antigen-presenting cells, especially DCs. Efficient delivery of mRNA into DCs in vivo remains a major challenge in the mRNA vaccine field. This review summarizes the principles of mRNA vaccines and highlights the importance of in vivo mRNA delivery and recent advances in harnessing their therapeutic potential.

Authors contributed equally to this work.

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Acknowledgements

We gratefully acknowledge helpful discussions with Katalin Karikó and Ugur Sahin.

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Authors and Affiliations

  1. BioNTech RNA Pharmaceuticals GmbH, An der Goldgrube 12, 55131, Mainz, Germany

    Christian Grunwitz, Lena M. Kranz & Lena M. Kranz

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  1. Christian Grunwitz
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  2. Lena M. Kranz
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Correspondence to Christian Grunwitz or Lena M. Kranz .

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Editors and Affiliations

  1. Faculty of Medicine, Cancer Sciences Unit, University of Southampton, Southhampton, United Kingdom

    Natalia Savelyeva

  2. Faculty of Medicine, Cancer Sciences Unit, University of Southampton , Southampton, United Kingdom

    Christian Ottensmeier

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Grunwitz, C., Kranz, L.M. (2017). mRNA Cancer Vaccines—Messages that Prevail. In: Savelyeva, N., Ottensmeier, C. (eds) Cancer Vaccines. Current Topics in Microbiology and Immunology, vol 405. Springer, Cham. https://doi.org/10.1007/82_2017_509

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