Background
Catalog Number:
CPTC-WFDC2-1
Target Antigen:
WAP Four-Disulfide Core Domain 2 Peptide 1
Isotype:
IgG
Species:
Rabbit Recombinant Cloned Antibody
Last Updated:
02/09/2024
Antigen Recognition(s):
Peptide
Purchase
- DSHB CPTC-WFDC2-1
Characterization Data [Compare Characterization Data]
Immuno-MRM
CPTC-WFDC2-1 iMRM screening (synthetic peptide)
Result: Positive
iMRM screening of CPTC-WFDC2-1 against synthetic peptide EGSC[+57]PQVNINFPQLGLC[+57]R (WAP Four-Disulfide Core Domain 2 Peptide 1)
Data provided by the Carr Lab, Broad Institute
https://www.broadinstitute.org/proteomics/protocols
Characterization SOP Files
NCI 60 Protein Array
CPTC-WFDC2-1 NCI 60 Protein Array
Result: Negative
This antibody is not suitable for use in a Reverse Phase Protein Array format as described in SOP M-105.
Characterization SOP Files
Background
NCI Identification Number:
00325
Antigen Name:
WAP Four-Disulfide Core Domain 2 Peptide 1
CPTC Name:
CPTC-WFDC2 Peptide 1
Aliases:
WAP Four-Disulfide Core Domain 2; WAP5; HE4; WAP Four-Disulfide Core Domain Protein 2; Major Epididymis-Specific Protein E4; Putative Protease Inhibitor WAP5; Epididymal Secretory Protein E4; Epididymal Protein 4; DJ461P17.6; EDDM4; Epididymis-Specific, Whey-Acidic Protein Type, Four-Disulfide Core; Epididymis Secretory Sperm Binding Protein; WAP Domain Containing Protein HE4-V4; WFDC2
Function:
This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. WFDC2 (WAP Four-Disulfide Core Domain 2) is a Protein Coding gene. Diseases associated with WFDC2 include Fallopian Tube Carcinoma and Ovarian Cancer. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity and cysteine-type endopeptidase inhibitor activity.Broad range protease inhibitor.
Chromosomal Localization:
20q13.12
Accession Number:
NP_006094.3
UniProt Accession Number:
Q14508
DNA Source:
N/A
Immunogen:
Synthetic Peptide
Vector Name:
N/A
Extinction Coefficient:
Buffers:
Expressed Sequence:
EGSCPQVNINFPQLGLCR
Native Sequence:
Calculated Isoelectric Point:
Molecular Weight:
1980
Last Updated:
08/21/2020
Links
- EnsEMBL - EnsEMBL WFDC2
- Entrez - Entrez WFDC2
- Uniprot - Uniprot Q14508
Characterization Data
SOPs
No SOPs available.
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