Background
Catalog Number:
CPTC-TNNI3-1
Target Antigen:
Troponin I3, Cardiac Type Peptide 1
Isotype:
IgG
Species:
Rabbit Recombinant Cloned Antibody
Last Updated:
10/19/2023
Antigen Recognition(s):
Peptide
Characterization Data [Compare Characterization Data]
IHC HPA
Download This PDF provides the evaluation results as provided by the Human Protein Atlas (www.proteinatlas.org). (397.8 KB)
CPTC-TNNI3-1 evaluation by the Human Protein Atlas
Result: Negative
This PDF provides the evaluation results as provided by the Human Protein Atlas (www.proteinatlas.org).
Characterization SOP Files
Immuno-MRM
CPTC-TNNI3-1 iMRM
Result: Positive
iMRM data obtained using antibody CPTC-TNNI3-1 to immuno-precipitate peptide NITEIADLTQK (CPTC-TNNI3 Peptide 1)
Data provided by the Carr Lab, Broad Institute
https://www.broadinstitute.org/proteomics/protocols
Characterization SOP Files
Immunofluorescence - HPA
Download This PDF provides the evaluation results as provided by the Human Protein Atlas (www.proteinatlas.org). (397.8 KB)
CPTC-TNNI3-1 evaluation by the Human Protein Atlas
Result: Negative
This PDF provides the evaluation results as provided by the Human Protein Atlas (www.proteinatlas.org).
Characterization SOP Files
Western Blot - Recombinant Protein or Peptide
CPTC-TNNI3-1 Recombinant Protein WB
Result: Negative
Automated Western Blot with recombinant TNNI3 protein
Characterization SOP Files
Background
NCI Identification Number:
00336
Antigen Name:
Troponin I3, Cardiac Type Peptide 1
CPTC Name:
CPTC-TNNI3 Peptide 1
Aliases:
Troponin I3, Cardiac Type; TNNC1; Cardiomyopathy, Dilated 2A (Autosomal Recessive); Troponin I, Cardiac Muscle; CMH7; Cardiac Troponin I; Troponin I Type 3; CMD1FF; CMD2A; TNNI3; RCM1; CTnI
Function:
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).TNNI3 (Troponin I3, Cardiac Type) is a Protein Coding gene. Diseases associated with TNNI3 include Cardiomyopathy, Dilated, 2A and Cardiomyopathy, Familial Hypertrophic, 7. Among its related pathways are Signal transduction_PKA signaling and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include protein kinase binding and protein domain specific binding. An important paralog of this gene is TNNI1.Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Chromosomal Localization:
19q13.42
Accession Number:
NP_000354.4
UniProt Accession Number:
P19429
DNA Source:
N/A
Immunogen:
Synthetic Peptide
Vector Name:
N/A
Extinction Coefficient:
Buffers:
Expressed Sequence:
NITEIADLTQK
Native Sequence:
Calculated Isoelectric Point:
Molecular Weight:
1210
Last Updated:
08/23/2020
Links
- EnsEMBL - EnsEMBL TNNI3
- Entrez - Entrez TNNI3
- Uniprot - Uniprot P19429
Characterization Data
SOPs
No SOPs available.
Don't have Adobe Reader™?
Get it for free at Adobe.com