Neurogenesis in the adult human hippocampus
- PMID: 9809557
- DOI: 10.1038/3305
Neurogenesis in the adult human hippocampus
Abstract
The genesis of new cells, including neurons, in the adult human brain has not yet been demonstrated. This study was undertaken to investigate whether neurogenesis occurs in the adult human brain, in regions previously identified as neurogenic in adult rodents and monkeys. Human brain tissue was obtained postmortem from patients who had been treated with the thymidine analog, bromodeoxyuridine (BrdU), that labels DNA during the S phase. Using immunofluorescent labeling for BrdU and for one of the neuronal markers, NeuN, calbindin or neuron specific enolase (NSE), we demonstrate that new neurons, as defined by these markers, are generated from dividing progenitor cells in the dentate gyrus of adult humans. Our results further indicate that the human hippocampus retains its ability to generate neurons throughout life.
Comment in
-
Take comfort in human neurogenesis.Nat Med. 1998 Nov;4(11):1207. doi: 10.1038/3166. Nat Med. 1998. PMID: 9809518 No abstract available.
Similar articles
-
Immunohistological markers for staging neurogenesis in adult hippocampus.Cell Tissue Res. 2007 Sep;329(3):409-20. doi: 10.1007/s00441-007-0432-4. Epub 2007 May 31. Cell Tissue Res. 2007. PMID: 17541643 Review.
-
Differential regulation of gliogenesis in the context of adult hippocampal neurogenesis in mice.Glia. 2004 Apr 1;46(1):41-52. doi: 10.1002/glia.10337. Glia. 2004. PMID: 14999812
-
Dentate gyrus neurogenesis after cerebral ischemia and behavioral training.Biol Res Nurs. 2005 Jan;6(3):167-79. doi: 10.1177/1099800404271328. Biol Res Nurs. 2005. PMID: 15583357
-
Differential properties of dentate gyrus and CA1 neural precursors.J Neurobiol. 2005 Feb 5;62(2):243-61. doi: 10.1002/neu.20089. J Neurobiol. 2005. PMID: 15459894
-
Neurogenesis in the adult hippocampus.Hippocampus. 2006;16(3):199-207. doi: 10.1002/hipo.20151. Hippocampus. 2006. PMID: 16411231 Review.
Cited by
-
Transcriptomic analysis of CNTF-treated mouse subventricular zone-derived neurosphere culture reveals key transcription factor genes related to adult neurogenesis.Heliyon. 2024 Sep 28;10(19):e38496. doi: 10.1016/j.heliyon.2024.e38496. eCollection 2024 Oct 15. Heliyon. 2024. PMID: 39430537 Free PMC article.
-
The endogenous regenerative capacity of the damaged newborn brain: boosting neurogenesis with mesenchymal stem cell treatment.J Cereb Blood Flow Metab. 2013 May;33(5):625-34. doi: 10.1038/jcbfm.2013.3. Epub 2013 Feb 13. J Cereb Blood Flow Metab. 2013. PMID: 23403379 Free PMC article. Review.
-
PPARγ agonists promote oligodendrocyte differentiation of neural stem cells by modulating stemness and differentiation genes.PLoS One. 2012;7(11):e50500. doi: 10.1371/journal.pone.0050500. Epub 2012 Nov 21. PLoS One. 2012. PMID: 23185633 Free PMC article.
-
Deltamethrin Exposure Inhibits Adult Hippocampal Neurogenesis and Causes Deficits in Learning and Memory in Mice.Toxicol Sci. 2020 Dec 1;178(2):347-357. doi: 10.1093/toxsci/kfaa144. Toxicol Sci. 2020. PMID: 32976580 Free PMC article.
-
Defining the cognitive enhancing properties of video games: Steps Towards Standardization and Translation.Postdoc J. 2016 Sep;4(9):32-36. doi: 10.14304/surya.jpr.v4n9.5. Postdoc J. 2016. PMID: 27747256 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
