NK cell receptors
- PMID: 9597134
- DOI: 10.1146/annurev.immunol.16.1.359
NK cell receptors
Abstract
NK cells are regulated by opposing signals from receptors that activate and inhibit effector function. While positive stimulation may be initiated by an array of costimulatory receptors, specificity is provided by inhibitory signals transduced by receptors for MHC class I. Three distinct receptor families, Ly49, CD94/NKG2, and KIR, are involved in NK cell recognition of polymorphic MHC class I molecules. A common pathway of inhibitory signaling is provided by ITIM sequences in the cytoplasmic domains of these otherwise structurally diverse receptors. Upon ligand binding and activation, the inhibitory NK cell receptors become tyrosine phosphorylated and recruit tyrosine phosphatases, SHP-1 and possibly SHP-2, resulting in inhibition of NK cell-mediated cytotoxicity and cytokine expression. Recent studies suggest these inhibitory NK cell receptors are members of a larger superfamily containing ITIM sequences, the inhibitory receptor superfamily (IRS).
Similar articles
-
Intracellular signaling by the killer immunoglobulin-like receptors and Ly49.Sci STKE. 2001 Mar 27;2001(75):re1. doi: 10.1126/stke.2001.75.re1. Sci STKE. 2001. PMID: 11752646 Review.
-
Expression of p58.2 or CD94/NKG2A inhibitory receptors in an NK-like cell line, YTINDY, leads to HLA Class I-mediated inhibition of cytotoxicity in the p58.2- but not the CD94/NKG2A-expressing transfectant.Cell Immunol. 2002 Sep;219(1):57-70. doi: 10.1016/s0008-8749(02)00578-6. Cell Immunol. 2002. PMID: 12473268
-
SHP-1- and phosphotyrosine-independent inhibitory signaling by a killer cell Ig-like receptor cytoplasmic domain in human NK cells.J Immunol. 2002 May 15;168(10):5047-57. doi: 10.4049/jimmunol.168.10.5047. J Immunol. 2002. PMID: 11994457
-
Structure and function of major histocompatibility complex (MHC) class I specific receptors expressed on human natural killer (NK) cells.Mol Immunol. 2002 Feb;38(9):637-60. doi: 10.1016/s0161-5890(01)00107-9. Mol Immunol. 2002. PMID: 11858820 Review.
-
Impaired natural killing of MHC class I-deficient targets by NK cells expressing a catalytically inactive form of SHP-1.J Immunol. 2000 Aug 1;165(3):1314-21. doi: 10.4049/jimmunol.165.3.1314. J Immunol. 2000. PMID: 10903732
Cited by
-
NK cells controlling virus-specific T cells: Rheostats for acute vs. persistent infections.Virology. 2013 Jan 5;435(1):37-45. doi: 10.1016/j.virol.2012.10.005. Virology. 2013. PMID: 23217614 Free PMC article. Review.
-
LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity.Cell. 2024 Aug 8;187(16):4336-4354.e19. doi: 10.1016/j.cell.2024.07.018. Cell. 2024. PMID: 39121847
-
Natural killer lytic-associated molecule plays a role in controlling tumor dissemination and metastasis.Front Immunol. 2012 Dec 24;3:393. doi: 10.3389/fimmu.2012.00393. eCollection 2012. Front Immunol. 2012. PMID: 23269922 Free PMC article.
-
Cellular and molecular basis of haploidentical hematopoietic stem cell transplantation in the successful treatment of high-risk leukemias: role of alloreactive NK cells.Front Immunol. 2013 Feb 1;4:15. doi: 10.3389/fimmu.2013.00015. eCollection 2013. Front Immunol. 2013. PMID: 23378843 Free PMC article.
-
Central nervous system acute lymphoblastic leukemia: role of natural killer cells.Blood. 2015 May 28;125(22):3420-31. doi: 10.1182/blood-2014-08-595108. Epub 2015 Apr 20. Blood. 2015. PMID: 25896649 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous
