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Clinical Trial
. 1997 Jul 4;277(5322):112-6.
doi: 10.1126/science.277.5322.112.

Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease

B Autran  1 , G Carcelain, T S Li, C Blanc, D Mathez, R Tubiana, C Katlama, P Debré, J Leibowitch
Affiliations
Clinical Trial

Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease

B Autran et al. Science. .

Abstract

Highly active antiretroviral therapy (HAART) increases CD4(+) cell numbers, but its ability to correct the human immunodeficiency virus (HIV)-induced immune deficiency remains unknown. A three-phase T cell reconstitution was demonstrated after HAART, with: (i) an early rise of memory CD4(+) cells, (ii) a reduction in T cell activation correlated to the decreasing retroviral activity together with an improved CD4(+) T cell reactivity to recall antigens, and (iii) a late rise of "naïve" CD4(+) lymphocytes while CD8(+) T cells declined, however, without complete normalization of these parameters. Thus, decreasing the HIV load can reverse HIV-driven activation and CD4(+) T cell defects in advanced HIV-infected patients.

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Comment in

  • Recovering from the ravages HIV.
    Cohen J. Cohen J. Science. 1997 Jul 4;277(5322):33. doi: 10.1126/science.277.5322.33. Science. 1997. PMID: 9229769 No abstract available.

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